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Neuro - Week 7 > Schizophrenia > Flashcards

Schizophrenia Flashcards

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1
Q

General term used to describe a distorted perception of reality

A

Psychosis

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2
Q

fixed, false belief that remain despite evidence to the contrary and cannot be accounted for by the cultural background of the individual

A

Delusions

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3
Q

This type of delusion is a false belief that is impossible

A

Bizarre delusion

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4
Q

This type of delusion is a false belief that is plausible but is not true

A

Nonbizarre delusion

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5
Q

This category of delusion is an irrational belief that one is being persecuted

A

Delusions of persecution

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6
Q

This category of delusion is a belief that cues in the external environment are uniquely related to them

A

Ideas of reference

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7
Q

A patient who believed that TV characters are speaking directly to them, is having this category of delusion

A

Ideas of reference

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8
Q

This category of delusion is thought broadcasting and thought insertions

A

Delusions of control

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9
Q

This category of delusion is a belief that one has special powers beyond those of a normal person

A

Delusions of grandeur

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10
Q

This category of delusion is belief that one is infected with a disease

A

Somatic delusions

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11
Q

Heterogeneous syndrome of disorganized and bizarre thoughts, delusions, hallucinations, inappropriate affect, and impaired psychosocial functioning

A

Schizophrenia

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12
Q

When is the typical onset of Schizophrenia?

A

Between 19 and 40 years

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13
Q

Delusions, perceptual disturbances, thought disorder, and disorganized behavior are in this schizophrenia cluster

A

Positive cluster

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14
Q

misinterpretation of an existing sensory stimulus

A

Illusion

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15
Q

sensory perception without actual external stimulus

A

Hallucination

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16
Q

This is the most common type of hallucination

A

Auditory

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17
Q

What is alogia?

A

Reduction in speech
(thought blocking; latency to answer)

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18
Q

This schizophrenia symptom in the negative cluster is decreased interests, social activities, relationships problems

A

Anhedonia

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19
Q

This schizophrenia symptom in the negative cluster is a lack of drive; apathy
Characterized by poor hygiene, decreased motivation (catatonia), decreased goal directed activity

A

Avolition

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20
Q

Impaired executive functioning is in this schizophrenia cluster

A

cognitive cluster

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21
Q

These are the three phases of schizophrenia

A

Prodromal
Psychotic
Residual

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22
Q

This phase of schizophrenia is a decline in function that precedes the first psychotic episode

A

Prodromal

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23
Q

This phase of schizophrenia is a loss of touch with reality, perceptual disturbances, delusions, and disordered thought process

A

Psychotic

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24
Q

This phase of schizophrenia occurs following an episode of active psychosis, marked by mild hallucinations or delusions, social withdrawal, and negative symptoms

A

Residual

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25
Is being male or female a poor prognostic factor for schizophrenia?
Male
26
Is pharmacotherapy an essential element of schizophrenia treatment?
YES
27
What is the MOA of atypical (2nd gen) antipsychotics?
Direct blockade of 5-HT2A receptors
28
Atypical (2nd gen) antipsychotics directly block these receptors
5-HT2A receptors
29
These drugs appear to work by compensatory changes in response to persistent serotonin-2A antagonism and D2 antagonism in limbic (mesolimbic) areas
Atypical (2nd gen) antipsychotics
30
Do Atypical (2nd gen) antipsychotics affect motor systems?
Minimal (contrast to typicals, which cause motor disorders)
31
Do typical or atypical psychotics cause motor disorders?
typicals
32
Risperidone is this type of drug
Atypical (2nd gen) antipsychotic
33
Quetiapine is this type of drug
Atypical (2nd gen) antipsychotic
34
Aripiprazole is this type of drug
Atypical (2nd gen) antipsychotic
35
Do Typical or Atypical antipsychotics have an adverse effect of increased risk of seizures?
Atypical (2nd gen)
36
Do Typical or Atypical antipsychotics have an adverse effect of hyperlipidemia?
Atypical (2nd gen)
37
Do Typical or Atypical antipsychotics have an adverse effect of hyperglycemia?
Atypical (2nd gen)
38
Do Typical or Atypical antipsychotics have an adverse effect of QT prolongation?
Atypical (2nd gen)
39
This atypical antipsychotic especially has a risk of QT prolongation
Ziprasidone
40
Do Typical or Atypical antipsychotics have an adverse effect of dementia-related psychosis?
Atypical (2nd gen)
41
This is the most effective antipsychotic
Clozapine
42
Clozapine blocks these receptors
D1, D4, 5-HT2 receptor
43
This antipsychotic has a black box warning of hypotension and hypertension risk
Clozapine
44
This antipsychotic has glucose intolerance and diabetes risk
Clozapine
45
This antipsychotic has a black box warning of agranulocytosis
Clozapine
46
This antipsychotic has a relatively low incidence of extrapyramidal side effects, including tardive dyskinesias but requires frequent monitoring
Clozapine
47
Is Clozapine toxic to the heart?
Yes - cardiac toxicity is a black box warning
48
Risperidone blocks these receptors
D2 and 5-HT2
49
This antipsychotic has limited effect in nigra-striatal structures at normal (low) therapeutic doses Higher doses may produce motor dysfunction (extrapyramidal motor signs), hyperprolactinemia, sexual dysfunction
Risperidone
50
Side effects of this antipsychotic include orthostatic hypotension and reflex tachycardia
Risperidone
51
Is orthostatic hypotension or hypertension a side effect of risperidone?
Hypotension
52
Is reflex bradycardia or tachycardia a side effect of risperidone?
Tachycardia
53
A long acting injectable is available of this atypical antipsychotic
Risperidone
54
Cataracts observed in animals occurs with this atypical antipsychotic
Quetiapine
55
This side effect is observed in animals with Quetiapine
Cataracts
56
Eye exams are recommended every 6 months for this atypical antipsychotic, which is an alpha-adrenergic blocker
Quetiapine
57
This antipsychotic is a D2 and muscarinic receptor antagonist and 5HT2A receptor inverse agonist
Olanzapine
58
Drug reaction with eosinophilia and systemic symptoms (DRESS) can occur with this atypical antipsychotic
Olanzapine
59
Ziprasidone is an antagonist of these
D2, 5HT2 and alpha-1
60
QT prolongation and risk of sudden death are side effects of this atypical antipsychotic Requires EKG monitoring
Ziprasidone
61
What is the main adverse effect of Ziprasidone?
QT prolongation and risk of sudden death
62
Suicidality and dementia-related psychosis (avoid use) are black box warnings of this atypical antipsychotic
Aripiprazole
63
This drug is less sedating and less weight gain than other atypical antipsychotics
Aripiprazole
64
Does aripiprazole cause more or less sedation and weight gain than other atypicals?
Less
65
What is the MOA of typical antipsychotics?
Blockade of D2 receptors in mesolimbic areas
66
Typical antipsychotics block this receptor
D2
67
Is this the MOA of typical or atypical antipsychotics: Direct blockade of 5-HT2A receptors
Atypical
68
Is this the MOA of typical or atypical antipsychotics: Blockade of D2 receptors in mesolimbic areas
Typical
69
Are typical or atypical antipsychotics effective but with movement disorders?
Typical
70
Haloperidol is this type of drug
Typical antipsychotic
71
Thioridazine is this type of drug
Typical antipsychotic
72
Thiothixene is this type of drug
Typical antipsychotic
73
Phenothiazines is another name for this type of antipsychotic
Typicals
74
Do Typical or Atypical antipsychotics have an adverse effect of anti-histamine, anti-adrenergic, anti-muscarinic?
Typicals
75
Do Typical or Atypical antipsychotics have an adverse effect of extrapyramidal symptoms (dopamine blockade)?
Typicals
76
Do Typical or Atypical antipsychotics have an adverse effect of neuroleptic malignant syndrome? (Fever, autonomic instability, leukocytosis, tremor, elevated CPK, rigidity, excessive sweating, delirium)
Typicals
77
This disorder involves Oro-facio-lingual daytime movements possibly associated with larger movements of trunks or extremities May occur as part of progression of psychosis or as result of therapy with dopamine receptor antagonists (typical antipsychotics)
Tardive dyskinesias
78
Do typical or atypical antipsychotics block serotonin receptors?
Atypical
79
Do typical or atypical antipsychotics block dopamine receptors?
Typical
80
Do typical or atypical antipsychotics possibly cause Tardive dyskinesias?
Typicals (due to dopamine antagonism)
81
This is the agent of choice for acute episodes of psychosis
Haloperidol (A Butyrophenone - typical antipsychotic)
82
Haloperidol is the agent of choice for this psychosis
Acute episodes
83
Thioxanthenes and Butyrophenones are this type of antipsychotic
Typical (first gen)
84
This has the same criteria as schizophrenia, but symptoms have lasted between 1 and 6 months
Schizophreniform disorder
85
Schizophreniform disorder has the same criteria as schizophrenia, but symptoms have lasted this amount of time
Between 1 and 6 months
86
This has the same criteria as schizophrenia but symptoms last less than 1 month with eventual full return to premorbid functioning
Brief psychotic disorder
87
Brief psychotic disorder has the same criteria as schizophrenia but symptoms last this amount of time
Less than 1 month
88
In this disorder, patients meet criteria for either depression or mania AND schizophrenia
Schizoaffective disorder
89
Patients with Schizoaffective disorder meet criteria for schizophrenia and either of these
Depression or mania
90
In Schizoaffective disorder, delusions and hallucinations must be noted for this amount of time in the absence of mood disorder
2 weeks
91
This is a personality disorder of paranoid, odd or magical beliefs, eccentric, lack of friends and social anxiety Psychosis criteria is not met
Schizotypal
92
This is a personality disorder of solitary activities, lack of enjoyment from social interactions, no psychosis
Schizoid

Neuro - Week 7 (5 decks)

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