Schizophrenia Flashcards

(38 cards)

1
Q

What are the costs of schizophrenia?

A
  • Enormous suffering
  • Less likely to have children, hold down a job, more poverty
  • Suicide rate >10x the general population
  • Approx 10% of homeless people have schizophrenia
  • Huge financial cost
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2
Q

Approximately how many homeless people have schizophrenia?

A

Approx. 10% of homeless people have schizophrenia

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3
Q

Schizophrenia is associated with profound changes in ______

A

Perception, cognition and emotion

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4
Q

What are schizophrenia symptoms traditionally divided into?

A

Positive symptoms and negative symptoms

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5
Q

What does the 3 factor model consist of?

A
  1. Reality distortion (psychotic symptoms)
  2. Disorganisation
    3. Negative Symptoms
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6
Q

What are some types of psychotic symptoms?

A

Hallucinations (abnormal perceptions) and delusions (abnormal beliefs)

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7
Q

What are hallucinations?

A

Hallucinations are abnormal perceptions
 Hearing things, seeing things, smelling things
(etc.) that other people can’t

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8
Q

Which kind of hallucinations are most common? What is the prevalence?

A

Auditory hallucinations. Present in ~70% of SZ patients. Visual, tactile, olfactory hallucinations can also occur.

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9
Q

What are AVHs and what are they usually like?

A

AVHs (auditory verbal hallucinations) typically critical or abusive, often commenting on the person’s actions and often more than one voice.

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10
Q

What are delusions?

A

Delusions are abnormal beliefs. Very common in SZ (>80% of sufferers)

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11
Q

What are examples of common delusions in schizophrenia?

A

 Paranoid delusions: person believes that others are trying to harm them
 Delusions of control: person believes their body is being controlled by an external agent
 Delusions of reference: person believes that the words of actions of strangers have special relevance to them


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12
Q

What is disorganisation?

A

Disorganization refers to disconnected or incomprehensible thought and speech, bizarre behaviour

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13
Q

Who was Emile Kraepelin (1856-1926)?

A

Kraepelin was the first to classify types of mental disorders based on systematic empirical observations. He offered diagnostic categories defined by common patterns of symptoms

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14
Q

What was Kraeplin’s system, and current systems, like?

A

Kraepelin’s system – and most current diagnostic systems – imply that mental disorders are separate entities. That is, for any given mental disorder, you either have it OR you do not.

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15
Q

What is formal thought disorder and what does it involve?

A

Formal thought disorder (FTD) refers to disorganized thinking as evidenced by disorganized speech
 Loose associations
 Tangential thinking
 ‘Word salad’

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16
Q

What are some examples of disorganised behaviour?

A

FTD
Inappropriate affect
Bizzare dress

17
Q

What are negative symptoms?

A

Negative symptoms represent deficits in normal behaviour and cognition. Somewhat similar to the symptoms of MDD.

18
Q

How are negative symptoms of SZ similar to the symptoms of MDD?

A

Flat affect
- Blank stare
Alogia (poverty of speech)
- When talking, lack of ideas, repetitive
Avolition (poverty of will)
- Similar to depression, lack of motivation
- However, person is not bothered by this
Cognitive deterioration

19
Q

What are some psychotic symptoms which are more characteristic of SZ than others?

A

Schneider suggested that FRS were the most characteristic symptoms of SZ. Empirical studies show you can get FRS in other kinds of illnesses, but particularly common in schizophrenia.

20
Q

What are first-rank symptoms?

A
Audible thoughts (thought echo)
Voices heard arguing
Voices commenting on one’s action
Delusions of control
Thought withdrawal, insertion, broadcast
  • Schneider thought that these symptoms were diagnostic.
21
Q

Common examples of FRS

A
  • Delusions of control (actions being controlled by an external force)
  • Delusions of thought insertion (Thoughts inserted into mind by someone else)
  • Third-person auditory hallucinations (Two or more voices talking about the patient or commenting on actions)
22
Q

James Tilly Matthew - who was he?

A

The first documented case of ‘paranoid’ schizophrenia - suffered from delusions of thought insertions; thought the French was forcing thoughts into mind

23
Q

Kurt Schneider

A

Suggested that the FRS were the most characteristic symptoms of schizophrenia. Also thought that any one of them was diagnostic, but it appears that they also occur in other psychotic disorders (bipolar).

24
Q

What is the major alternative classification system? Where is it most used?

A

The major alternative classification system is the International Statistical Classification of Diseases and Related Health Problems (ICD-10)
More popular in Europe.

25
Misattribution hypothesis of SZ
All reflect confusion between self-generated and externally-generated thoughts and actions.
26
What are corollary discharges?
Corollary discharges are neural copies of motor signals.
27
What is the purpose of corollary discharges?
They are often sent to predict and suppress the response of sensory neurons to self-generated actions. Mechanism for distinguishing between sensations arising from self-generated actions and sensations arising from changes in the external world
28
Corollary discharge theory of schizophrenia
If corollary discharges represent a mechanism for distinguishing between self-generated and externally- generated sensations  And SZ patients have difficulties in distinguishing between self-generated and externally-generated actions. Are the symptoms of schizophrenia caused by corollary discharge abnormalities?
29
Blakemore et al. 1998
fMRI scanner - people tickle themselves vs experimenter tickle. Reduction in activity in the secondary somatosensory cortex when self-generated tickle.
30
secondary somatosensory cortex?
Responsible for the perception of touch
31
Blakemore et al., 2000 - Evidence of corollary discharge abnormalities in schizophrenia
3 groups: SZ patients with FRS, SZ patients with symptoms absent, and healthy controls. Results: Healthy controls and SZ w/o FRS found self-tickling less ticklish. However self-generated and externally generated perceived as equal in SZ patients with FRS.
32
What are the environmental risk factors for schizophrenia?
Methamphetamine (speed): Up to 10x general population level; it is a dopamine agonist Now incontrovertible that high levels of dopamine associated with psychotic symptoms of SZ
33
Rozelle Hospital study 1973 (Bell)
Dopamine agonists produce FRS psychotic symptoms. - 16 addicts given large doses of meth - 12 patients developed paranoid psychosis; most common was ideas of reference
34
What do all antipsychotics do?
Block dopamine receptors. Therapeutic dose strongly related to drug's binding affinity to D2.
35
Dopamine hypothesis of SZ
Psychotic symptoms of SZ are caused by hyperactivity of the dopaminergic system
36
Problems with antipsychotics
Often not completely effective - residual psychosis They treat the symptoms, not the cause. Invariably will relapse and start experiencing psychosis if withdrawn. Do not work for disorganisation and negative symptoms.
37
Novel therapies
TMS - SZ - under-activity in frontal lobe - Use TMS to stimulate
38
Trower et al.
Psychological therapy - Training patients to live better with symptoms. Command hallucinations - Good utility as an adjunct to pharmacotherapy - CBT for Schizophrenia - treatment results up to 12 months