Schizophrenia Flashcards

(29 cards)

1
Q

What is schizophrenia?

A

A disorder characterised by psychotic symptoms plus functional impairment
- Is chronic and relapsing

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2
Q

Define positive symptoms

A

Delusions
Hallucinations
Agitation
Thought disorder

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3
Q

Define negative symptoms

A
Lack of will
Lack of interest
Isolation 
Social and occupational withdrawal 
Intellectual decline
Poor memory and attention
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4
Q

Give some causes of schizophrenia

A

Predisposing

  • Biological = genetic
  • Psychological = ?parenting
  • Social = ?immigration

Precipitating
Bio = Drug use, poor compliance
Psycho = stress

Perpetuating

  • Psycho = relationship
  • Social = role in society
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5
Q

When does schizophrenia usually present?

A

Late adolescence or early adulthood

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6
Q

Give the prevalence of schizophrenia

A

3/1000 of the population

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7
Q

What are the main ways the schizophrenia progresses?

A
1/3 = single episode
1/3 = relapsing illness with minimal residual damage
1/3 = progressive deterioration
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8
Q

What pre-mormid factors give rise to a poorer prognosis?

A
  • FH schizophrenia
  • Personal history of any psychiatric disorder
  • Eccentric shy personality
  • Poor social and psychosexual adjustment
  • Single civil status
  • Unstable work record
  • Young age
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9
Q

What clinical indicators give an indication of a poorer prognosis?

A
  • Insidious onset
  • Blunted affect
  • Prolonged episode
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10
Q

What types of delusions can people with schizophrenia have?

A

Delusions of reference
Delusions of persecution
Delusions of passivity

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11
Q

Define delusion of reference

A

An event or action has a special meaning to the patient - believe things are meant specifically just for them e.g. messages in the paper, voices on the radio

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12
Q

Define a delusion of persecution

A

Patient feels that they are being followed.

Are paranoid.

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13
Q

Define a delusion of passivity

A

Delusion in which the person feels that their actions are under control of other people.

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14
Q

What kind of auditory hallucinations do people with schizophrenia have?

A
  • Thought spoken aloud
  • Third person hallucinations
  • Commentary
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15
Q

What are the first rank symptoms of schizophrenia?

A
Auditory hallucinations
Thought withdrawal
Thought insertion
Thought broadcasting
Somatic hallucinations
Delusional perception
Feelings or actions which are experienced as being by external sources
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16
Q

Define thought withdrawal

A

The delusion that thoughts have been removed from a patients mind

17
Q

Define thought insertion

A

The delusion that thoughts are not their own but have been implanted by an external source.

18
Q

Define thought broadcasting

A
Patient believe that their thoughts are being broadcasts to the outside world. 
Can be via:
Telepathy
Radio broadcasting 
Newspaper is reporting their thoughts
19
Q

Define a delusional perception

A

Real perceptions gives rise to a false meaning

20
Q

Define somatic hallucinations

A

Tactile hallucinations such as insects crawling over their skin, the feeling of being touched or strangled

21
Q

Define a thought disorder

A

Cognitive processing is scrambled and gives rise to a number of different factors.

22
Q

What kind of things can arise in thought disorders?

A
  • Neologisms - create new words
  • Stock phrases
  • Clang associations - thoughts are connected by the words sounding the same
  • Concrete thinking
  • Derailment - changing from one subject to another
  • Knight’s move thinking - leaping rapidly from one to another
  • Omission
  • Drivelling
  • Over-inclusive thinking
23
Q

What are the differential diagnoses for schizophrenia?

A
Brief psychotic reaction
Severe depression with psychosis
Bipolar with psychosis
Schizoid personality disorder
Schizoaffective disorder
Drug induced psychosis
Organic symptoms
24
Q

What is the first line treatment for schizophrenia?

A

Oral atypical antipsychotics such as:

  • Olanzapine
  • Risperidone
  • Quetiapine
  • Amisulpiride
25
What medication can be used in treatment resistant schizophrenia?
Clozapine
26
What is the main side effect of using clozapine?
Neutropenia | - Need weekly blood tests for 6 months
27
What are the side effects of antipsychotic medication?
Antidopaminergic | - EPS such as Parkinsonian, acute dystonia, akathisia, tardive dyskinesia
28
What is the main theory for the pathology of schizophrenia?
Increase dopamine function in mesolimbic pathway and decreased dopamine in the mesocortical pathway.
29
What are the main pathways involved with dopamine in the brain?
Mesolimbic pathway Mesocortical pathway Nigrostriatal pathway Tubero-hypophyseal