Schizophrenia Flashcards

(48 cards)

1
Q

A Criteria Symptoms of Schizophrenia

A

Negative Sx: Alogia, Affective Flattening, Avolution, Anhedonia

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2
Q

Positive Symptoms of Schizophrenia

A

Delusions, Disorganized Thinking, Hallucinations

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3
Q

Which gender is more likely to have A Criteria Sx of Schizophrenia?

A

Males >Females

A Criteria Sx = Negative Sx

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4
Q

A Criteria Sx for Schizophrenia for 1 to 6 months

Dx?

A

Schizophreniform Disorder

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5
Q

What must be done before diagnosing Schizphrenia?

A

Rule out other diagnosis: other psychotic disorders, childhood developmental disorders, medical/neurological disease, substance abuse, medication induced, personality disorder, mood disorders

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6
Q

Cognitive Symptoms of Schizophrenia

A
SMART:
Speed
Memory
Attention
Reasoning
Tact (Social Cognition)
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7
Q

What A Criteria Negative Sx of Schizphrenia is also a sx of major depression

A

Anhedonia

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8
Q

Criteria to meet DSM-5’s A Criteria of Schizophrenia

A

Of 2 sx, 1 needs to be :

Delusion, Hallucination, Disorganized thinking/speech

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9
Q

What is catatoni

A

Stupor, waxy flexibility, mutism, negativsm, echolalia

Seen in schizophrenia and other disorders

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10
Q

What is hyponopompic hallucinations?

A

Auditory hallucinations heard when patient is waking up from sleeping

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11
Q

Which symptoms of schizophrenia present early in the illness?

A

Negative/Cognitive Sx

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12
Q

Do negative symptoms worsen or improve during hte active periods of schizophrenia?

A

Worsen

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13
Q

Do antipsychotic medications work well for negative symptoms of schizophrenia?

A

No

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14
Q

What % of schizophrenics get married and why?

A

Only 30-40% due to limited social contacts

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15
Q

What % of schizphrenic patients experience only a single active episode?

A

10%

30% intermittent course, 60% chronic course

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16
Q

What sign is seen in 85% of patients prior to first psychotic episode? How long does it last?

A

Prodrome: Lasts several months to years

This is a negative prognostic sign

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17
Q

Why do females and males have the same peak age of onset (mode) but different average age of onset?

A

2nd smaller peak age of onset peak seen in females after age 40

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18
Q

Why do schizophrenics have a life expectancy that is 25 years less than the general population?

A

Cardiovascular Disease

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19
Q

When does the functional decline begin in a patient with schizophrenia

A

Prodrome

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20
Q

Which gender is the average course of schizophrenia more severe in? Why?

A

Males >Females

Males generally develop illness earlier

21
Q

What is the main goal of continuous antipsychotic treatment in patients with schizophrenia

A

Prevent relapse into active phase

22
Q

What happens when decreasing antipsychotic medication dose to use lowest effective dose?

A

Increased risk of relapse

23
Q

Most common reason patients with schizophrenia are hospitalized

A

Psychosis/Active Phase

24
Q

Most antipsychotic medications are unlikely to work by 4 weeks if what? What medication is the exception

A

If a patient does not show a response wtihin 2 weeks

EXCEPTION: Clozapine (Clozaril)

25
Why are lower doses of antipsychotics used to treat patients with first active phase of schizophrenia
Greater sensitivity to med SE
26
Which medications have the unique benefit for decreasing risk of suicide?
Clozapine (Clozaril) for schizophrenia | Lithium for Bipolar Disorder
27
Indications for Clozapine (Clozaril) Trial
Persistence of Positive Sx Failure of >2 antipsychotic trials Comorbid Substance Abuse Recurrent Suicidality/Violence
28
What % of dopamine receptors need to be blocked with FGAs to see SE?
75-80%
29
What % of dopamine receptors need to be blocked in what pathway to have the desired antipsychotic effect?
At least 65% blocked | Mesolimbic Tract
30
Low Potency Antipsychotics SE
Anticholinergic: dry mouth, constipation, blurry eyes, urinary hesitancy
31
What is dystonia and who is at higher risk than general population?
EPS Side Effect of muscle spasm | Younger Males are at greater risk
32
Once a patient develops Tardive Dyskinesia, the most common course is:
Remain Static/Unchanged
33
What is the first choice medication for treating akathisia? | What other drugs can be used?
1st Line: Propranolol Others: Amantadine, Lorazepam (Ativan), Clonidine, Mirtazepine (Remeron)
34
Can diphenhydramine (Benadryl) be used to treat EPS? Why or why not?
YES | Due to anticholinergic effects
35
Which FGA has less chance of developing EPS symptoms in patients?
Low Potency FGA: Chlorpromazine (Thorazine)
36
About half of the patients with tardive dyskinesia show a 50% symptom reduction from treatment with this medication
Clozapine (Clozaril)
37
What age group has 50% of developing tardive dyskinesia after taking FGAs for 2 years
Geriatric (>70)
38
What is Akathisia
EPS SE: subjective sense of restlessness
39
Which SGA have the least risk of EPS SE
Clozapine (Clozaril) | Quetiapine (Seroquel)
40
Which SGA is most likely to cause akathisia?
Aripipraole (Abilifty)
41
Which SGA has long half life and low risk of metabolic syndrome?
Aripiprazole (Abilify)
42
Which SGA are available in long acting injectable form but with risk of dose dependent EPS and hyperprolactinemia?
Risperidone (Risperdal) | Palliperidone (Invega)
43
Name the SGA Low Risk of Metabolic Syndrome Needs to be taken with food Causes QTc prologation
Ziprasidone (Geodon)
44
Which SGA was shown by the CATIE study that patients were highly likely to be compliant? What is the downside of this drug?
Olanzapine (Zyprexa) | SE: High risk of metabolic syndrome, very sedating
45
Which SGA is an active metabolite of risperidone (Risperdal)
Palliperidone (Invega)
46
Properties of Quetiapine (Seroquel)
SGA: No risk of EPS or Agranulocytosis Sedating Moderate risk of metabolic syndrome
47
Unique property of Aripiprazole (Abilifty) amongst SGA
Partial Agonist
48
SE of Clozapine (Clozaril)
SGA | SE: Sialorrhea, Weight Gain, Sedation, Anticholinergic, Myocarditis, Lower Seizure Threshold