Schizophrenia and Psychotic Disorders Flashcards

(77 cards)

1
Q

The 3 principle psychotic disorders

A

Delirium
Schizophrenia
Affective psychosis

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2
Q

Definition of psychosis

A

Represents an inability to distinguish between symptoms of delusion, hallucination and disordered thinking from reality

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3
Q

Main symptom of schizophrenia

A

lack of insight

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4
Q

What does a predisposing factor mean?

A

putting you at risk

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5
Q

What does a precipitating factor mean?

A

something that starts it

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6
Q

What does a perpetuating factor mean?

A

keeping it going

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7
Q

Presentation of psychosis

A
Hallucinations
- full force and clarity of true perception 
- located in external space
- no external stimulus 
- not willed or controlled 
Delusional beliefs 
- grandiose
- paranoid (correctly persecutory)
- hypochondrial 
- self referential 
Lacks insight
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8
Q

5 special senses of hallucinations

A
Auditory 
Visual 
Tactile (touching you)
Olfactory 
Gustatory (Taste)
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9
Q

Definition of delusion

A

An unshakable idea or belief which is out of keeping with the persons social or cultural background; it is held with extraordinary conviction

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10
Q

Illnesses that have psychotic symptoms

A

Schizophrenia
Delerium
Severe affective disorder

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11
Q

What is severe affective disorder?

A

Either
- depressive episode with psychotic symptoms
OR
- manic episode with psychotic symptoms

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12
Q

Differential diagnosis of psychosis

A
Delerium 
Acute organic brain syndrome
Depressive episodes with psychotic symptoms 
Manic episodes with psychotic symptoms 
Schizophrenia 
Making it up e.g. in a police case
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13
Q

Features of psychosis caused by delirium or acute organic brain syndrome

A

Prominent visual experience, hallucinations and illusions
Affect of terror
Delusions are persecutory and evanescent (quickly disappear)
Fluctuating worse at night

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14
Q

Definition of an illusion

A

Abnormal perception of a real thing

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15
Q

Features of psychosis caused by depressive episode with psychotic symptoms

A

Delusions of guilt, worthlessness and persecution

Derogatory and auditory hallucinations

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16
Q

Features of psychosis caused by a manic episode with psychotic symptoms

A

Delusions of grandeur; special powers or messianic roles
Gross overactivity, irritability and behavioural disturbance
Manic excitement

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17
Q

Treatment of psychosis

A

Early intervention - family and psychological
Community treatment
Antipsychotics
Treatment to prevent relapse during remission
CBT
Cognitive remediation
Social skills training

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18
Q

Definition of schizophrenia

A

A severe mental illness affecting thinking, emotion and behaviour

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19
Q

What is the most common cause of psychosis?

A

Schizophrenia

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20
Q

Who gets schizophrenia?

A

M = F

onset 15-35 years

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21
Q

Possible biological causes of schizophrenia

A
genetics
neurochemistry (glutamate, GABA)
obstetric complications
maternal influenza
malnutrition and famine
winter birth 
substance misuse e.g. cannabis
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22
Q

Symptoms of schizophrenia

A
Positive
- hallucinations
- delusions
- disordered thinking
Negative
- apathy 
- lack of interest
- lack of emotions
- alogia 
- disturbed attention
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23
Q

What is a “positive” symptom?

A

A dramatic, more obvious symptom

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24
Q

ICD-10 Criteria for schizophrenia

A

> 1 month in the absence of organic or affective disorder
At least 1 of the following
- alteration of thought; echo, thought insertion, thought withdrawal, thought broadcasting
- delusions of control, influence or passivity (other people controlling you), clearly referred to body or limb movements - actions or sensations
- hallucinatory voices giving a running commentary on patients behaviour, or discussing him between themselves or other voices coming from somewhere in the body
- persistent delusions that are culturally inappropriate and completely impossible (e.g. controlling weather)
And OR at least two of the following
- persistent hallucinations of any modality, when occurring every day for at least 1 month
- Neologisms, breaks or interpolations in train of thought, resulting in incoherence or irrelevant speech
- Catatonic behaviour, such as excitement, posturing or wavy flexibility, negativism, mutism and stupor

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25
Good prognostic factors for schizophrenia
``` Absence of FH Good premorbid function Clear precipitant Acute onset Mood disturbance Prompt treatment Maintenance of initiative, motivation ```
26
Poor prognostic factors for schizophrenia
``` Slow, insidious, early onset Prominent negative symptoms Starts in childhood Male Unmarried Non paranoid type Negative / catatonic symptoms Absence of affective symptoms FH ```
27
5 criteria for detention under the Mental Health Act
``` Mental illness Risk Treatment SIDMA - severely impaired decision making Least restrictive option/necessary ```
28
Once detained under the mental health act, what happens?
Investigations to rule out organic cause May need 24 hour observation by e.g. nurse Start antipsychotic
29
What type of symptoms do patients experience when they have their 1st presentation?
+ve symptoms
30
What is the most common symptom of schizophrenia?
Auditory hallucinations
31
Definition of alogia
Poverty of speech
32
Can treatment for schizophrenia be given under the mental health act?
Yes
33
Complications of schizophrenia
Suicide (4 - 10%) | Social and occupational decline
34
What is the drug most associated with schizophrenia?
Cannabis
35
When do men present in comparison to women?
Men present on average 5 years earlier
36
What can trigger a presentation of acute schizophrenia?
Big life stress
37
Differentials for psychosis
Schizotypical, schizoaffective and other delusional disorders Mania Delerium Drug abuse / medications Cerebral tumour / infarct / TLE / infection Endocrine disease (thyroid, chronic hypoglycaemia, cushings, addisons) Anaemia / carcinoma / sarcoid
38
Type of hallucinations, delirium vs schizophrenia
Delerium - visual | Schizophrenia - auditory
39
What % of people with schizophrenia have 1 episode only?
20%
40
Types of schizophrenia
``` Paranoid Hebephrenic (disorganised) Catatonic (motor) Simple Residual Post schizo depression Not otherwise specified ```
41
What is the most common type of schizophrenia?
Paranoid
42
What happens in paranoid schizophrenia?
Systemised delusions and hallucinations
43
What happens in hebenephric schizophrenia?
Delusions, thought form disorder, disturbed affect
44
What is the treatment for catatonic schizophrenia?
Lorazepam
45
What happens in residual schizophrenia?
Predominately -ve symptoms
46
What happens in simple schizophrenia?
Only -ve symptoms
47
What are 1st rank symptoms strongly suggestive of?
Schizophrenia
48
Where can 1st rank symptoms be seen?
Schizophrenia Organic disorders Mood disorders
49
Types of delusions
Paranoid / persecutory Grandeur Nilhilistic Reference
50
What is an over valued idea?
Less than a delusion as not fully convicted
51
Definition of a pseudohallucination
Persons thoughts become alienated from them inside their head etc in trauma. They often know it is their own thoughts causing this
52
What is circumstantiality?
The inability to answer a question without giving excessive, unnecessary detail
53
What are clang associations?
Describes speech in which topics are related to each other only by sounding something similar
54
What are flight of ideas?
Describes speech in which there is rapid changing of subjects, unrelated to one another
55
What is preservation?
Describes repetition of speech on the same subject, despite attempting to change the subject
56
What is tangentiality?
Describes speech that wanders from a topic, without returning to it
57
What are neologisms?
New word formations, which might include the combining of two words
58
What is word salad?
Completely incoherent speech where real words are strung together into nonsense sentences
59
What is knights move?
Severe type of loosening of associations, where there are unexpected and illogical leaps from one idea to another
60
What is knights move a feature of?
Schizophrenia
61
What is flight of ideas a feature of usually?
Mania
62
What is echolalia?
A repetition of someone elses speech, including the question that was asked
63
What may antipsychotics cause?
Akathisia
64
What is akathisia?
Severe restlessness
65
Which atypical antipsychotic has the most tolerance S/E profile, particularly for prolactin elevation?
Aripriprazole
66
What treatment is now first line for schizophrenic patients?
Atypical antipsychotics
67
What is the main advantage of atypical agents?
They have a significant reduction in extrapyramidal S/Es
68
S/Es of atypical antipsychotics
Weight gain Clozapine - agranulocytosis Hyperprolactinaemia
69
What risks are there for using antipsychotics in the elderly population?
Increased risk of - stroke - VTE
70
Examples of atypical antipsychotics
``` Clozapine Olanzapine Risperidone Quetiapine Amisulpride Arirpiprazole ```
71
S/Es of clozapine
Agranulocytosis (1%) and neutropenia (3%) Reduced seizure threshold (can induce seizures in up to 3% of patients) Constipation Myocarditis (ECG before starting Tx) Hypersalviation
72
Due to clozapines S/Es, what does this mean in terms of treatment?
Only used in patients who are resistant to other antipsychotic medication
73
When may the dose of clozapine have to be adjusted?
If smoking is stopped or started during the treatment
74
Patients with poor oral compliance of anti-psychotics can be switched to what?
Once monthly IM antipsychotic depot injections
75
What is used to assess the severity of schizophrenia?
Positive and negative syndrome scale (PANSS)
76
What does tardive dyskinesia present as a S/E of and how does it present?
``` Due to late onset abnormal involuntary choreoathethoid movements in patients on conventional antipsychotics Can present as - chewing - jaw pouting - excessive blinking ```
77
What is it important to do if a patient is on clozapine and develops an infection?
FBC - as need to exclude neutropenia due to clozapine