Schizophrenia Content Flashcards

1
Q

What is DSM-5

A

Way of classifying SZ

- includes one positive symptom being present (delusions, hallucinations or speech disorganisation)

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2
Q

What is ICD-10

A

Classification of SZ

- two or more negative symptoms are needed for diagnosis (avolition and speech poverty)

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3
Q

Positive symptoms of SZ

A
  • additional experiences beyond those of ordinary experience
    1. Hallucinations – sensory experiences that have no basis in reality or distorted perceptions of real things, experiences in relation to any sense
    2. Delusions beliefs that have no basis in society – make a person with SZ behave in ways that make sense to them but bizarre to others e.g. Victim of conspiracy
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4
Q

Negative symptoms of SZ

A
  • loss of usual abilities and experiences
    1. Avolition – severe loss of motivation to carry out everyday tasks e.g. Work, hobbies and personal care
  • results in lower activity levels and unwillingness to carry out goal-directed behaviours
    2. Speech poverty – a reduction in the amount and quality of speech - may include a deal in verbal responses during conversation
  • DSM emphasises speech disorganisation and incoherence
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5
Q

What are the issues in diagnosis of SZ

A

Reliability – extent to which the diagnosis of SZ is consistent
Validity - extent to which the diagnosis and classification techniques measure what they are designed to measure what they are designed to
Co-Morbidity - occurrence of two illnesses together which confuses diagnosis and treatment
Symptom Overlap - when two or more conditions share symptoms

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6
Q

What is the genetic basis of SZ

A
  • Strong relationship between similarity of family members and likelihood of both developing SZ
  • each individual gene confers a small increased risk of SZ – polygenic
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7
Q

What is the dopamine hypothesis

A
  • featured in the functioning on the brain systems related to the symptoms of SZ

Hyperdopaminergia – high dopamine in sub cortex associated with hallucinations and poverty of speech
Hypodopaminergia – recent versions have focused on the low levels of dopamine in the prefrontal cortex (responsible for thinking and decision making)

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8
Q

What are neural correlates in SZ

A
  • measurements of the structure or function of the brain that correlate with positive or negative symptoms

Ventral Striatum – involved in anticipation of reward causing a loss of motivation in SZ as a result of low activity levels there

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9
Q

Name the psychological explanations of SZ

A

Family dysfunction and cognitive explanations

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10
Q

What does family dysfunction include

A

Schizophrenogenic mothers, double-bind theory and expressed emotion

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11
Q

Explain schizophrenogenic mothers

A
  • patients early experiences with those types of mothers
  • these mothers are cold, rejecting and controlling and create a family climate of tension and secrecy which causes distrust, paranoid delusions and SZ
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12
Q

Explain double-bind theory and who suggested it

A

Bateson - described how a child may be regularly trapped in situations where they fear doing the wrong thing but receive conflicting messages about what counts as wrong

  • cannot express their feelings about unfairness of the situation
  • when they ‘get it wrong’ child is punished by withdrawal of love so learn the world is confusing and dangerous
  • leads to disorganised thinking and delusions
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13
Q

Explain expressed emotions

A

level of emotion expresses towards the schizophrenogenic patient and includes:
- verbal criticism of the patient
- hostility towards them
- emotional over-involement in their life
high levels of EE cause stress in the patient – primary explanation for relapse

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14
Q

What do cognitive explanations include

A

dysfunctional thought processing
meta-representation
dysfunction of central control

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15
Q

Explain dysfunctional thought processing

A
  • lower levels of information processing in some areas of the brain suggest cognition is impaired e.g. reduced processing in ventral striatum is associated with negative symptoms
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16
Q

What is dysfunction of central control and who said it?

A

Frith – cognitive ability to suppress automatic response while performing deliberate actions
- people with SZ experience derailment of thoughts and spoken sentences because each word triggers automatic association they cannot suppress

17
Q

What is the biological therapies for SZ

A

Drug therapies

18
Q

what are antipsychotic drugs?

A

most common
pills, injections and syrup
reduce intensity of symptoms

19
Q

What is the name of a Typical Antipsychotic

A

Chlorazapine

20
Q

outline Chlorazapine

A
  • start at a low dosage and build up to - 400-800mg
  • anatagnoist chemicals reduce action of neurotransmitter - blocks dopamine receptors in the brain
    it normalises transmitters in key areas of the brain
    reduces symptoms like hallucinations
21
Q

What is an atypical antipsychotic

A

Clozapine

22
Q

Outline Clozapine

A
  • newer
  • more effective with fewer side effects
  • was trialled in 1970s - led to death of patients as it killed blood cells so was withdrawn
  • relaunched as more effective with regular blood checks
  • 300-450mg