Schizophrenia + psychosis Flashcards

(32 cards)

1
Q

voices history - what do you explore?

A
volume + number
2nd / 3rd person / commanding
content
recognition + gender
exacerbating/relieving factors
pattern over day

V2-CREP

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2
Q

things to ask about in schizophrenia history (thoughts)

A
insertion
withdrawal
broadcasting
TV/radio refer to you
out to get you? people against you/want to harm you
powers?

IWB-TOP powers

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3
Q

what aspects of thought content are used to differentiate schizophrenia from psychosis due to depression etc?

A

insertion, withdrawal, broadcasting

also consider congruence of hallucinations + presence of negative symptoms

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4
Q

negative symptoms of schizophrenia

A
apathy + anhedonia
sexual problems
social withdrawal
blunted/incongruous emotional responses
lethargy
inattention
poverty of speech

ASS BLIP

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5
Q

differentials for what seems like negative symptoms

A

positive symptoms causing them eg hallucinations

medication SEs

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6
Q

schneider’s first rank symptoms

A

1 - Thought disorder (insertion, withdrawal, broadcasting)
2 - Auditory hallucinations (echo, commentary, discussion)
3 - Passivity phenomena
4 - Delusional perceptions

someones TAPD my brain

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7
Q

differentials for psychosis

A
schizophrenia
schizoaffective
depression (congruent)
mania/bipolar (congruent)
postpartum psychosis

drugs - toxicity or withdrawal
organic - tumour / injury / infection

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8
Q

organic causes of psychosis

A

brain tumour/injury/infection
alcohol + drugs
delirium + dementia
BAD

BADMAN:
brain tumour/injury
acute confusional state
dementia
medication SEs
autoimmune - SLE, thyroid disease
nervous system infection - neurosyphilis, encephalitis
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9
Q

differentiating bipolar mania from schizophrenia

A

schizophrenia - thought echo, running commentary etc

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10
Q

management of first presentation psychosis

A

oral antipsychotic
psychological interventions - CBT + family interventions
refer to EIT

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11
Q

schneider’s first rank symptoms - criteria for the auditory hallucinations

A

3rd person discussing pt
thought echo (hears thoughts spoken aloud)
running commentary

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12
Q

schneider’s first rank symptoms - criteria for thought disorder

A

insertion
withdrawal
broadcasting - to others, no longer private

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13
Q

schneider’s first rank symptoms - passivity phenomena

A

external agent is controlling mind/body - delusions of control

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14
Q

schneider’s first rank symptoms - delusional perceptions

A

normal object perceived > delusional insight into its meaning eg. light green > i am king

person believes that a normal percept has a special meaning for him or her

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15
Q

diagnostic criteria for schizophrenia

A

other causes ruled out
for 6mo + much of the time for 1mo + marked impairment in functioning:

1 clear or 2 less clear:

1 - thought insertion, broadcasting, withdrawal
2 - voices - running commentary or discussing patient
3 - delusions - perceptions, of control, influence or passivity
4 - persistent delusions of other kinds

OR at least 2 - PINC:

1 - persistent hallucinations (any type) - daily for weeks
2 - incoherent/irrelevant speech (breaks/interpolations in train of thought)
3 - negative symptoms
4 - catatonic behaviour

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16
Q

how does CBT help in schizophrenia?

A

help patient understand symptoms better + develop alternative ways of coping

17
Q

how do family interventions help in schizophrenia?

A

help families understand condition + respond to symptoms in the most supportive way

18
Q

CPA - what is it + how does it work?

A

MDT care coordinated by a keyworker
written care plan
says how to get help in a crisis
reviewed + updated every 6-12mo

19
Q

psychosocial interventions for schizophrenia

A

supported work placements/employment support
rehabilitation
addresses issues with housing + benefits

20
Q

what to use if antipsychotic compliance poor?

A

risperidone depot

21
Q

what to do if poor response to antipsychotic?

A

cross-taper to a new drug

if that doesn’t work, combo therapy

22
Q

checks required before starting antipsychotics

A

history - activity/diet, personal/FH (diabetes, heart, BP)
obs - obs, glucose, BMI, ECG
bloods - FBC, U+Es, LFTs, HbA1c, lipids
specifics - prolactin, examine for movement disorders

23
Q

monitoring of antipsychotics

A

6-monthly
weight + HbA1c
U+E + LFT
prolactin

24
Q

SEs antipsychotics

A

CNS - drowsiness + seizures
CV - weight, diabetes, CV risks, QTc prolongation
prolactin - sexual dysfunction

EPSEs less likely

25
clozapine - SEs (medical)
``` weight gain agranulocytosis - monitor FBC tachycardia constipation hypersalivation myocarditis increased/decreased/postural BP nausea drowsiness seizures ``` WATCH-MINDS - people with schizophrenia think people are watching their mind
26
specific anitpsychotic complications - olanzapine, zotepine, risperidone
olanzapine - stroke zotepine - QTc prolongation risperidone - hyperprolactinaemia - stiffness, swollen breasts, periods stopping
27
lithium - SE vs sign of toxicity
fine tremor - SE | coarse tremor - toxicity
28
EPSEs
akathisia - urge to move constantly dyskinesia - abnormal/impaired voluntary movements acute dystonia - abnormal muscle tone → spasms + abnormal posture parkinsonism - bradykinesia, tremor, rigidity tardive dyskinesia - involuntary movements of face + body ADAPT to life on these drugs
29
when is clozapine used
when symptoms haven't responded to 2 others
30
initiation of clozapine
dose needs to be titrated due to effects on BP + HR (can fatally drop BP) 48h rule - can only do 48h without it before retitrating
31
clozapine - SEs to counsel
serious - agranulocytosis (monitor FBC) CNS - drowsiness + seizures CV - BP, HR etc - come for checks GI - nausea, constipation, weight gain, hypersalivation
32
schizophrenia/first episode psychosis - investigations + management
rule out other cause: tox screen full bloods (FBC, U+E, LFT, TFT, BoPr) neuro exam + imaging if signs risk assess refer to early intervention team - CPA atypical antipsychotic CBT + family intervention CV risk management