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Flashcards in Scientists Deck (36)
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Provided experimental evidence of acquired immunologic tolerance

Milan Hasek

1

Was an early pioneer in the study of the human major histocompatibility complex or HLA

Jean Dausset

2

Introduced radioimmunoassay

Rosalyn Yalow

3

Made crucial discoveries about the structure of immunoglobulins, the first complete sequence of antibody molecule

Gerald Edelman

4

Discovered IgE as reagins antibody

Kimishige Ishazaka

5

Discovered that bursa of fabricious is responsible for generating the cells capable of manufacturing antibodies - B cells

Noel Warmer

6

Were interested in transplantation

E. Doumal Thomas and Joseph Murray

7

Discovered the adaptive immunity is mediated by lypmohocytes, focusing the attention of immunologists on these small cells

James Gowans

8

Developed the hemolytic plaque assay and several important immunological theories, including an early version of clonal selection, a prediction that lymphocyte receptors would be inherently biased to MHC recognition, and the idiotype network

Niels Jerne

9

Pioneered monoclonal antibody production from hybrid antibody-forming cells with Ceasar Milstein

George Kohler

10

Pioneered monoclonal antibody production with Georgea Kohler

Cesar Milstein

11

Worked out the polypeptide structure of the antibody molecule, layering the groundwork for its analysis by protein sequencing

Rodney Porter

12

Discovered the somatic recombination of immunological receptor genes that underlies the generation of diversity in human and murine antibodies and T cell receptors

Susumo Tonegawa

13

Linked the two theories by showing that humoral and cellular factors were involved in a normal immune response. He observed that humoral or circulating factors called opsonins coated bacteria rendering them susceptible to phagocytosis. This observation gave him the idea that serum factors were formed in response to exposure to foreign substances. He called these serum facctors, antibodies

Almoth wright

14

Discovered immune response genes and collaborated in the first demonstration of MHC restriction

Baruj benecerraf

15

Formulated the genetic theory of tumor transplation

Clarence Little

16

Developed the quantitative precipitin assay, ushering in the era if quantitative immunochemistry

Michael Heidelberger

17

Provided evidence for identity of the gene for blood group antigens with one gene for tumor resistance in mouse

Peter Gorer

18

In addition to his discovery of delayed hypersensitivity reactions, introduced the immune phenomenon he studied --- that immunity could be transfered from one animal to the other by means of serum

Clemens von Pirquet

19

Provided evidence that antibodies are gamma globulins

Arne Tiselius and Elvin Kabat

20

Introduced fluoresence labeling of antibodies

Albert Coons

21

Introduced adjuvants

Jules Freund

22

Used skin graft to show that tolerance is acquired characteristic of the lymphoid cells - a key feature of the cional selection theory

Peter Medawar

23

Proposed the first generally accepted clonal selectuon hypothesis of adaptive immunity

Frank MacFarlane Burnet

24

Reported that dizygotic twin cattle, which were true chimeras, were immunologically tolerant of each other tissues and serum - description of tolerance (chimerism) in dizygotic cattle twins

Ray Owen

25

Worked out the genetics on murine MHC & generated the congenic strains needed for its biological analysis laying the groundwork for our current understanding of MHC in T cell biology

George Snell

26

Developed precipitin test in gels and the idiotypes

Jacques Ouidin

27

Discovered immunoglobulins as "transporeurs"

Pierre Grabar

28

Developed double immunodiffusion test in gels

Orjan Ouchterlony and Stephen Elek

29

Discovered plasma cells as antibody producing cells

Astrud Fargaeus