Screening

Question 1

1 in 700 births

Answer 1

Parker et al (2010)

Question 2

Standard Trisomy 21 88% mother

Answer 2

Zhang (2008)

Question 3

Heart defects are common in T21/T18/T13

Answer 3

Pandya (1995)

Question 4

Risk increases with maternal age

Answer 4

Morris, Mutton & Alberman (2002)

Question 5

Combined Screening PSRA 78-80% DR with 5% FPR

Answer 5

Wapner (2003) Wald & Hackshaw (1997)

Question 6

NT Neutral position (higher when extended lower when flexed)

Answer 6

Whitlow et al (1998)

Question 7

MSS Maternal weight (dilution effect)

Answer 7

Spencer et al (2003)

Question 8

MSS Smoker status

Answer 8

Spencer et al (2004)

Question 9

MSS Afro-Caribbean, South Asian, Oriental

Answer 9

Spencer et al (2005)

Question 10

Multiple regression analysis (weight, ethnicity, smoker status, method of conception)

Answer 10

Kagan (2008)

Question 11

Quad screen biomarkers (high)

Answer 11

hCG Inhibin-A

Question 12

Quad screen biomarkers (low)

Answer 12

AFP Estriol

Question 13

Quad screen has similar DR but higher FPR

Answer 13

Malone (2005) Wald (2003)

Question 14

Quad screen less cost effective

Answer 14

Cusick (2003)

Question 15

Combined test biomarkers

Answer 15

High hCG low PAPP-A