Screening for Immunologic Disease

Question 1

Where does most of your immunity occur?

Answer 1

2/3 in intestines

Question 2

What are common sx reported to PT?

Answer 2

new onset of jt pain, B jt swelling, progressive neuro sx 1-3 weeks, jt pain with eye rash or urine changes, constitutional sx with immunosuppressive meds

Question 3

Who should be screened?

Answer 3

anyone with prior hx of immune dz or family history

Question 4

What are two kinds of immunodeficiency disorders?

Answer 4

AIDS, HIV

Question 5

What are of HIV?

Answer 5

early- fever, night sweats, fatigue

advanced- purple blotches, HTN, dyspnea, infections, polyneuropathy

Question 6

What are common occurrences with AIDS?

Answer 6

karposi sarcome, TB, non hodgkins lymphoma

Question 7

What are two types of hypersensitivity immunological disorders?

Answer 7

anaphylaxis and cytolyic

Question 8

What is anaphylaxis?

Answer 8

systemic reaction that is immediate, vasodilation, bronchospasm, hives, tachycardia

NEED an epi pen

Question 9

What is cytolytic?

Answer 9

usually rejection of blood donation due to wrong type

SX- HA, back pain, angina, N/V. tacky and hypo

Question 10

What are two types of immunoproliferative disease?

Answer 10

immune complex and cell mediated

Question 11

What is an immune complex?

Answer 11

RA like- with fever jt pain, lymph enlargement, uticara, kidney lung heart involvement

Question 12

What is cell mediated?

Answer 12

24-72 hours after exposure, mantoux test, transplant rejection contact dermatitis

sx- itching and erhytema

Question 13

What are Sx of Reiter’s?

Answer 13

can’t see can’t pee can’t climb a tree

Question 14

What is PMR?

Answer 14

polymatic rheumitica

Question 15

What are risk factors for PMR?

Answer 15

over 55 women more than men linked with Hashimoto’s

sx: severe headache, aching, stiffness, AM pain, proximal weakness, depression

steroids are drug of choice

Question 16

What is scleroderma?

Answer 16

inflammation and fibrosis of skin, blood vessels, kidney,s lungs ,heart and GI tract

Question 17

What are sx of sclerdoma?

Answer 17

CREST

Calcinosis, Raynaud’s, Esophageal sx, sclerodactyl, telegiecstia

Question 18

What is Lyme dz?

Answer 18

tick bite with bacterial infection

Question 19

What are early sx of lyme?

Answer 19

3-30 days

flu like, red rash, HA, numbness, poor coordination

Question 20

What are late sx of lyme?

Answer 20

months after

arthritis, sleep issues, peripheral neuropathy

Question 21

What are risk factors for MS?

Answer 21

women more than men, peak at 30 years old

inflammatory demylenation of CNS

Question 22

What is first sign of ms?

Answer 22

visual impairments from optic nerve

Question 23

What are additional signs of MS?

Answer 23

ataxia, vertigo, fatigue

Question 24

What is Lhermitte’s sign?

Answer 24

neck flex causes radiating pain to spine and LE

Question 25

What is Guillian Barre?

Answer 25

inflammatory demyelination of PNS

always linked to recent infection, vaccination (1-3 weeks)

Question 26

What are sx of GB?

Answer 26

systemic weakness, LE first then to trunk and UE, hyporeflexia, fever, N/V

Question 27

What is myasthenia Gravis?

Answer 27

mm receptor block to ACTH, 20-30 y/o or over 50 more males then females

Question 28

What are sx of MG?

Answer 28

mm fatigue, worse with exertion, face muscle fatigue, ptosis (eyelid drop), proximal more than distal

Question 29

Who should be sent out immediately?

Answer 29

anaphalactic shock, jt pain with suspect infection, blue color to skin over jt with extreme pain (septic)

Question 30

Who should be sent out soon?

Answer 30

jt pain with constituional signs
symetrical jt pain
neruo sx within last 1-3 weeks after infection