screening in pregnancy Flashcards Preview

Obstetrics > screening in pregnancy > Flashcards

Flashcards in screening in pregnancy Deck (23):
1

when is diagnostic testing indicated

following prenatal test, if family history

2

when can CVS be performed and what is the advantage

11 weeks- so option of abortion is easier at this stage

3

what is done prior to CVS

ultrasound to confirm pregnancy and location of placenta

4

what are sampled in CVS

trophoblastic cells for karyotype (placenta)

5

how long do results take

2 days for karyotype, 3 weeks for enzyme and gene probe analysis

6

what happens to the genes

PCRd or cultured- culture is more accurate and info on all abnormalities

7

risk of miscarriage in CVS

2-4%

8

how is needle inserted in CVS

transabdominally or transcervically

9

when is amniocentesis performed

15-16 weeks

10

miscarriage amniocentesis

1% (5 if early- 10-13 weeks)

11

what is measures on amniocentesis

Amniotic fluid AFP and cells in fluid are cultured for karyotyping

12

how long does cell culture take in amniocentesis

3 weeks

13

what screening is recommended >20weeks

cordocentesis

14

what are early scans good at looking at

CNS, neck, GI, renal

15

what might fluid accumulation in the neck at 10-14 weeks show

fetal heart failure, anomaly of heart and vesels.

16

what happens to risk of abnormality with greater extent of fetal nuchal translucency

increases

17

what is nuchal translucency screening

used to see who may benefit from more invasive CVS, amnio.

18

other soft markers for downs

fetal nasal bone appearance, Doppler velocity - ductus venosus and tricuspid regurg

19

AFP as a marker

maternal AFP at 17 weeks- in 10% with high AFP there is a fetal malformation. decreased- chromosomal

20

what is the combined test in Downs tests

nuchal translucency, BHCG, PAPP-A (pregnancy associated plasma protein), and womans age

21

what is the integrated test in Downs tests

NT + PAPP-A in first trimester, quadruple test in 2nd trimester

22

what is the quadruple test

maternal AFP + unconjugated estriol + BHCG + inhibin-A + womans age in 2nd trimester

23

when is NT and serum tests done for Downs

11 weeks (10-13+6)