Flashcards in (SDL) Interpreting test results Deck (6)
What are the contents of a lab report?
- demographic details from request
- results from lab analysis
- references ranges from scientific knowledge
- comments and advice from experience (human and computer knowledge bases)
List strategies to improve test
- select a more 'normal' population
- use a combination of tests (eg. LFT profiles)
- combine tests to achieve a diagnostic goal eg. neonatal screening for PKU and hypothyroidism
- sensitive first line test (low cost)
- specific test for screen positives (higher cost)
What are the appropriate 'normal' populations?
- patients with similar presenting symptoms eg. chest pain
- same age
- same gender
- hospitalised 'normals'
- same underlying disease
List some factors that affect reference ranges
- time of month
- time of day
- time of year
(must bear in mind when interpreting results)
Glycosylation of protein leads to what?
Advanced glycosylated endproducts (AGE)
- non-enzymatic process
- rate of formation proportional to glucose concentration and time
- may explain long-term compilations of diabetes