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Neuroscience > Second Messengers > Flashcards

Second Messengers Flashcards

1
Q

Somatostatin

A

Neuropeptide
Widely distributed in brain
Has 2 forms
5 receptors- all bind with high affinity
Anti stress response
Deficits common in neurological disorders

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2
Q

Two features of alpha subunit of G proteins

A

Helical domain: buries GTP/GDP inside the protein

GTPase

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3
Q

Rho family

A

G proteins
Regulators of actin dynamics
Important in growth cone
Activates by alpha 12 and 13

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4
Q

by dimer interacts with…

A

G protein coupled inwardly rectifying k channels (GIRKs)

Activated GIRKs transport K out of membrane-> hyperpolarisaton

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5
Q

Arrestins bund to ____________________ and disrupt ________________. This leads to _____________________________. B-arrestins can act as ______________. These interact with GPCRs and ____________/______ adapter complexes. Promotes _______________.

A 
Phosphorylated GPCRs
Receptor-G protein coupling 
Adaptor proteins 
Clathrin/AP2 
Sequestration
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6
Q

GIPs

A

GPCR interacting proteins

Eg homer protein

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Neuroscience (3 decks)

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