Secondary Hemostasis Flashcards
(76 cards)
1
Q
Factor I
A
Fibrinogen
2
Q
Factor II
A
Prothrombin
3
Q
Factor III
A
Tissue Factor
4
Q
Factor IV
A
Calcium
5
Q
Factor V
A
Proaccelerin/ Labile factor
6
Q
Factor VII
A
Proconvertin / Stable Factor
7
Q
Factor VIII
A
Anti-hemophilic factor A
8
Q
Factor IX
A
Christmas factor
9
Q
Factor X
A
Stuart Prower Factor
10
Q
Factor XI
A
Antihemophilic Factor C
11
Q
Factor XII
A
Hageman Factor
12
Q
Factor XIII
A
Fibrin Stabilizing Factor
13
Q
Prekallekrin
A
Fletcher Factor
14
Q
High Molecular Weight Kininogen
A
Fitzgerald Factor
15
Q
What are the cofactors
A
Factor V & VIII
16
Q
What are the serine proteases
A
Factor II, VII, IX, X, XI, XII
17
Q
What are the Vit K. dependent factors?
A
1972
X, IX, VII, II
18
Q
What is present in Barium Sulfate Adsorbed Plasma?
A
All except Vit K. dependent factors (1972)
19
Q
Factor involved in all pathways
A
Factor IV (Calcium)
20
Q
Factors involved in the extrinsic pathway
A
Factor III, VII, and IV (Calcium)
21
Q
Factor Xa cleaves _ to _
A
Prothrombin (II) to thrombin (IIa)
22
Q
Factor IIa
A
Thrombin
23
Q
What does thrombin (IIa) cleave ?
A
Fibrinogen (I) to Fibrin
24
Q
Factors involved in the intrinsic pathway
A
Factor XII, XI, IX, VIII(Cofactor), IV
25
Factors involved in the common pathway
Factor X, V(Cofactor), II, XIII, IV
26
Factor Xa converts prothrombin to thrombin with the help of _
Factor V
27
The most common acquired clotting factor deficiency
Liver disease
28
The most common inherited clotting factor deficiency
Hemophilia A
29
The inheritance pattern of Hemophilia A
X-linked recessive
30
Other name for hemophilia A
Classic hemophilia / Royal's Disease
31
Deficiency in Hemophilia A
Factor VIII
32
Factor V deficiency is otherwise known as _
Owren's disease / Labile factor deficiency
33
Hemophilia B deficiency
Factor IX (Christmas Disease)
34
The inheritance pattern of Hemophilia B
X-linked recessive
| *Note: Most factor deficiencies are autosomal recessive except Hemophilia A and B
35
Factor XI deficiency
Hemophilia C (Rosenthal Deficiency)
36
Major site of inhibition
Endothelium and platelets
37
Major inhibitor of cofactors
Protein C
38
Cofactor of Protein C
Protein S
39
Vitamin K dependent inhibitors
Protein C and S
40
Factors degraded by Protein C and S
Cofactors Va and VIIIa
41
Major inhibitor of coagulation
Anti-thrombin III
42
Forms a complex with thrombin, kallikrein and plasmin to inhibit their functions
Alpha-2 microglobulin
43
Inhibits thrombin
Heparin / Heparin cofactor II
44
Normal value for the micro method of clotting time
2-4 min.
| Dale & Laidlaw's and Slide drop method
45
Clotting test that utilizes a capillary tube to note the clot formation
Dale & Laidlaw's
46
Clotting test that uses a glass slide, and lancet, and scoop the drop of blood every 30 sec. until fibrin string is produced
Slide drop method
47
Clotting method wherein whole blood is submerged in a water bath of 37C
Lee & White (NV. 7-15 min)
48
What pathway does PT measure?
Extrinsic and Common Pathway
49
What pathway does APTT measure?
Intrinsic and Common Pathway
50
Normal Value of Prothrombin time (PT)
10-12 sec.
51
Normal Value of Activated Partial Thromboplastin Time (APTT)?
25-35 sec.
52
The specific factor that PT and APTT are not sensitive to
FXIII
53
The test of choice to monitor Heparin therapy
APTT
54
Test of choice to monitor warfarin therapy
PT
55
Reagent utilized in PT
Simplastin
| contains thromboplastin to replace tissue factor and Calcium chloride
56
The component in Simplastin (reagent in PT) to replace tissue factor
Thromboplastin
57
The measure of sensitivity for the PT reagent
INR (International Normalized Ratio)
58
The normal INR for PT
2-3
59
Specimen needed for APTT
Platelet poor plasma (PPP)
60
Tests that uses Platelet Poor Plasma
1. APTT
2. Stypven Time (Russel Viper Venom Time)
3. Thrombin Time
4. Reptilase time
61
Determines problem in the common pathway only
Stypven Time (Russel Viper Venom Time)
62
Snake where platelin is extracted from in the russel viper venom time
Vipera russeli / East Indian Viper (N.V.6-10sec)
63
Tests that assess prolonged Fibrinogen deficiency
1. Thrombin Time (TCT/TT)
| 2. Reptilase
64
Thrombin time is unaffected/affected by heparin while reptilase is unaffected/affected by heparin
Thrombin: AFFECTED by Heparin
Reptilase: UNAFFECTED by Heparin
65
Snake where the enzyme for reptilase time (resembles thrombin) is extracted from
Bothrops Atrox snake
66
NV for Thrombin time
10-14 sec.
67
Reagent for Reptilase time
Atroxin
68
Test used for factor XIII
Duckert's test (5M Urea Solubility Test)
69
Normal result for the Duckert's test
Factor XIII insoluble to Urea when incubated for 24 hrs
If solube=Factor XIII deficiency
70
Blood: Anticoagulant ratio in a black tube
4:1
71
Factors activated at cold temperatures
Malamig sa 7/11
FVII and XI
72
Factors that will break down at temperatures above 37C
Labile Factors (7 &5)
FVII and V
73
Recommended processing time of APTT
Within 4 hrs
74
Recommended processing time for PT
Within 24 hrs
75
Factors present in Fresh Plasma
All
76
Factors not present in Aged Plasma
Cofactors V and VIII
