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HEMATOLOGY 2 > SECONDARY HEMOSTATIS > Flashcards

SECONDARY HEMOSTATIS Flashcards

(73 cards)

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1
Q

Coagulation factors are primarily produced in the

A

Liver

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2
Q

Made by Megakaryocyte and endothelial cells

A

The vWF and VIII:vWF

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3
Q

Increased factors in liver disease

A

Factor I and VIII

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4
Q

A Very good test to assess liver function in the acute setting because factor VII is needed for the extrinsic pathway

A

PT

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5
Q

Factor that Has the shortest half life of 6 hours

A

Factor VII

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6
Q

All deficiencies of coagulation factors are transmitted as _________ except for factor VIII and IX deficiencies which are transmitted as ________

A

Autosomal recessive ; x-linked recessive

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7
Q

Most concentrated of all the plasma procoagulants ; essential for platelet aggregation (links activated platelets through their GP IIb /IIIa platelet fibrinogen receptor) ; increases approximately 10 mg/dL per decade in the elderly

A

Fibrinogen

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8
Q

Fibrinogen 100 mg/dL or less than effect on PT and PTT

A

Prolonged

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9
Q

Factor II

A

Prothrombin

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10
Q

Factor III

A

Tissue factor / tissue thromboplastin / thrombokinase

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11
Q

Factor IV

A

Calcium ions

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12
Q

Factor V

A

Proaccelerin / labile factor / thrombogen

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13
Q

Mutant factor V

A

Factor V Leiden

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14
Q

Factors inactivated by protein C-protein S complex

A

Factors V & VIII

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15
Q

Factor V is not inactivated by the protein C and S complex which leas to

A

Excessive clot formation

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16
Q

Deficiency of factor V

A

Owren’s disease or parahemophilia

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17
Q

First factor to be affected by warfarin therapy ; shortest life span

A

Factor VII

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18
Q

FACTOR VII

A

Proconvertin / stable factor

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19
Q

Proconvertin half life

A

6 hours

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20
Q

Factor VIII

A

Antihemophilic factor A (AHF-A) / antihemophilic globulin (AHG)

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21
Q

Free factor ____ is unstable in plasma (it circulates bound to vWF) ; during coagulation, ______ cleaves ____ from vWF and activates it

A

Factor VIII ; thrombin ; factor VIII

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22
Q

Factor VIII deficiency

A

Hemphilia A or classic hemophilia

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23
Q

Refers to procoagulant portion ; measured by standard factor VIII assay and APTT ; markedly decreased in hemophilia A

A

Factor VII, Factor VIIIC, Factor VIII:C

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24
Q

Factor VIII complex that refers to the antigenic properties ; measured by immunoassays

A

Factor VIII:Ag

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25
Factor VIII complex which refers to the portion responsible for for platelet aggregation in the presence of Ristocetin ; termed as the Ristocetin cofactor
Factor VIIIR:RCo
26
Factor VIII complex required for normal platelet adhesion
Factor VIII:vWF
27
Antigenic portion oof the Von willebrand factor ; previously termed factor VIII related antigen (VIIIR:Ag) ; measured by immunoassay
vWF:Ag
28
Largest molecule in plasma
Von willebrand factor
29
Has receptor site for both platelets and collagen
VWF
30
Primary platelet surface receptor for vWF
GP Ib / IX / V
31
Factor IX
Christmas factor / antihemophilic B / plasma thromboplastin component (PTC)
32
FACTOR X
Stuart prower factor
33
Factor XI
Antihemophilic factor C / plasma thromboplastin antecedent
34
Hemphilia C / rosenthal syndrome
Factor XI deficiency
35
>50% of cases seen in Ashkenazi Jews
Factor XI deficiency
36
Factor XII
Hageman factor / glass factor / contact factor
37
Factor deficiency with no bleeding tendency and has thrombotic tendency
Factor XII
38
Factor XIII
Fibrin stabilizing factor / fibrinase / Laki-Lorand factor
39
Uses 5 M urea clot solubility test for detection (Duckert’s test)
Factor XIII
40
PREKALLIKREIN is aka
Fletcher factor
41
HMWK
High molecular weight kininogen / Reid factor / Williams factor / Fitzgerald factor / flaujeac factor
42
Also considered coagulation factors , collectively called before as platelet factor 3 PF-3
Phosphatidylserine
43
Eight coagulation factors are enzymes that circulate in an inactive form called
Zymogens
44
Zymogens
Prothrombin VII IX X XI XII PREKALLIKREIN XIII
45
Coagulation factors that act as cofactors
Tissue factor V VIII HMWK
46
INITKNRINSIC FACTORS
12, 11, 9, 8
47
EXTRINSIC FACTORS
3 and 7
48
COMMON PATHWAY FACTORS
10, 5, 2, 1
49
Fibrinogen group
1, 5, 8, 13
50
Thrombin sensitive group
Fibrinogen group
51
Absent in aged serum
Fibrinogen group
52
Vitamin k-independent
Fibrinogen group Contact group
53
Calcium dependent group
Fibrinogen group Prothrombin group
54
Fibrinogen group is increased in (PISO)
Pregnancy Inflammation Stress Oral contraceptive intake
55
Present in aged serum
Factors 7, 9 ,10
56
Prothrombin group
2, 7, 9, 10
57
Vitamin K dependent group
Prothrombin group
58
Prothrombin group is adsorbed in the plasma using either
Barium sulfate or aluminum hydroxide
59
Contact group
XII, XI, PK, HMWK,
60
Vitamin k-independent group
Contact group
61
Coagulation factors and coagulation proteins formed under conditions of vitamin K absence or antagonism ; do not participate in coagulation process
PIVKA (protein induced by Vit. K absence)
62
The concept of coagulation process is used extensively to interpret ____ lab tests and to identify factor deficiencies
In vitro
63
Activates factor 1, 5, 8
Thrombin
64
Tenase complex
Factors 9a, PF-3, calcium, 8a
65
Protrhombinase complex
10a, PF-3, calcium, 5a
66
Involved in all phases of coagulation, except in the contact phase
Calcium
67
NOT soluble to 5M urea
Stabilized fibrin clot
68
Normal physiologic needs the presence of two cell types for formation of coagulation complexes
Tissue factor bearing cells Platelets
69
Coagulation in vivo can be described as occurring in two phases
Initiation Propagation
70
Occurs on tissue factor-bearing cells and generates 3% to 5% of total thrombin produced
Initiation
71
Occurs on platelets ; produces 95% or more of the total total thrombin
Propagation
72
Activates factor IX and X, producing enough thrombin to activate platelet and factors V, VIII, XI
TF:VIIa
73
Coagulation proceed on activated platelet phospholipid membranes with the formation of ___:____ and __:___ complex, which produces a burst of thrombin that cleaves fibrinogen to fibrin
IXa:VIIIa and Xa:Va complexes

HEMATOLOGY 2 (7 decks)

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