Section 2 Lecture 1: Membrane Trafficking

Question 1

What are polarized cells

Answer 1

Cells that are different at either end. They have an apical and basolateral domain

Question 2

Describe the functions of polarized cells

Answer 2

• have different functions at different cell regions
• define inside vs outside
• transmit signals from one end to the other

Question 3

What are two ways that membrane trafficking can send different proteins to different domains

Answer 3

1) exocytosis directly to the target domain
2) exocytosis to any domain then endocytosis followed by recycling to the target domain

Question 4

What is an example of a polarized trafficking route

Answer 4

ER to golgi to plasma membrane

Question 5

What is an example of a sorting station

Answer 5

The trans-golgi network. proteins are organized

Question 6

how does most cargo move through the golgi and what is a main feature of this method

Answer 6

constitutive secretion. Specific signals are not required

Question 7

What are the three secretory pathways

Answer 7

1) signal-mediated diversion to lysosomes via endosomes
2) signal-mediated diversion to secretory vesicles (for regulated secretion
3) constitutive secretory pathway