Section 6 & 7 - Calculation Skills and Drug Monitoring

Question 1

What does 1% Mean (Drug Preparation)

Answer 1

1% = 1g in 100ml (10mg in 1ml)
Also: 1g in 100g (10mg in 1g)

Question 2

Which route of Vancomycin needs monitoring?

Answer 2

IV

Question 3

What is required for Vancomycin Monitoring?

Answer 3

Pre-dose “Trough” Concentrations (10-20mg/L)
Serial Renal Function

Question 4

What is required for Gentamicin monitoring?

Answer 4

Serum Levels (Both Peak and Trough) - Start measuring doses after 3 to 4 doses.
Serial Renal Function

Question 5

What is required for Statin monitoring?

Answer 5

Full Lipid Profile
TFTs (If symptomatic)
LFTs (Prior, 2-3 Months in and 12 Months)
Creatinine Kinase (If Myalgic)
Haemoglobin A1c (If at risk of diabetes)

Question 6

What is required for Methotrexate monitoring?

Answer 6

Pre-treatment - Exclude pregnancy, FBC, U&E, LFT.
Monitoring - FBC, U&E, LFT every 1-2 Wks.

Question 7

What is required for Amiodarone monitoring?

Answer 7

LFTs - Before treatment, then every 6 months.
Serum Potassium concentrations
CXR (Pre-treatment)
TFTs (Pre-treatment & 6 monthly TFTs)

Question 8

Carbimazole Monitoring

Answer 8

Monitor for Agranulocytosis

Question 9

ACEi Monitoring

Answer 9

Renal function and electrolytes are measured before and regularly throughout treatment.

Question 10

Digoxin Monitoring

Answer 10

Renal function and Electrolytes