Section C Flashcards

1
Q

Cell membrane

A

it is a semi-permiable organelle ,which allows material in and out of the cell
heads” pointing outward from the membrane
Hydrophobic “tails” pointing inward from the membrane
Also, consists of proteins and carbohydrates
(peripheral) and integral (embedded) proteins
Receptors
Channels
Carriers
Cholesterol molecules stabilize the membrane and provide a decrease in fluidity at low temp
Cell markers account for blood type
Glycoproteins and glycolipids attached to outer surface

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2
Q

Flagella

A

they are whip like hairs/tails

helps in the motility of the bacterium

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3
Q

Pili/Fimbriae:

A

are small hair like projections on the surface, allow bacteria to stick to the surface and also used to move DNA plasmids between bacteria

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4
Q

Plasmid :

A

DNA molecule that is separate from, and can replicate independently of, the chromosomal DNA.
They are double-stranded and, in many cases, circular. Plasmids usually occur naturally in bacteria.
Plasmids are responsible for the antibiotic
resistance .

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5
Q

Zygote

A

fertilized egg
Union of a sperm and an ovum
From the zygote other cells will be produced that have specific structures and functions

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6
Q

Differentiation

A

process of cells becoming specialized

Mature cells are usually more specialized or differentiated than immature cells

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7
Q

Nucleus

A

Large, spherical organelle that has a double membrane with holes or pores
Stores genetic information which directs all cell activities
Nuclear envelope separates nucleus from cytoplasm

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8
Q

Deoxyribonucleic acid (DNA)-

A

in the nucleus
blueprint to new cell creation
Deoxyribose C5H10O4

A pentose sugar like ribose or deoxyribose, a phosphate or polyphosphate group and a nitrogen containing base
Has a spine ( backbone) of alternating (repeating) deoxyribose (sugar) and phosphate molecule covalently bonded in a long chain
The 2 chains are held together by hydrogen bonds between the bases
Adenine is always bonded to Thymine and Cytosine bonded to Guanine
Joined by hydrogen bonds
DNA polynucleotide chains pair up with one another (primary structure)
Bond together in twisted double strand (double helix)
Double-helix wraps around some proteins (tertiary structure)
separate at the nucleotide base for replication

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9
Q

Nucleolus

A

in the nucleus

Chromatin- coils to chromosomes before the cell divide

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10
Q

Histones

A

holds chromosomes together

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11
Q

Nucleoli -

A

Contains rRNA
Site where ribosomes are formed
Ribosomes are small bodies in the cytoplasm containing RNA and protein

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12
Q

Cytoplasm

A

Between the cell membrane and nucleus
Cytosol
Liquid portion
Made up of water, proteins, ions, and nutrients

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13
Q

Mitochondria

A

Responsible for producing cell energy, in the form of molecules called adenosine triphosphate (ATP)
Contains DNA and can direct the synthesis of some proteins

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14
Q

Ribosomes

A

Responsible for the production of proteins
Made up of ribosomal ribonucleic acid (RNA)
Found “free” in the cytoplasm or bound to endoplasmic reticulum

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15
Q

Endoplasmic Reticulum (ER)

A

Network of channels
Rough ER has ribosomes attached to it
-Responsible for synthesis and processing of proteins, and transporting them to the Golgi apparatus

Smooth ER lacks ribosomes
-Responsible for the synthesis of lipids and the detoxification of substances

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16
Q

Golgi apparatus

A

Six or so stacked membranous sacs called cisternae

Responsible for processing, packaging, and transporting proteins that were synthesized by the rough ER

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17
Q

Vesicles

A

Small membrane-bound sacs

Responsible for transport various substances in the cell as well as to the cell membrane for export out of the cell

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18
Q

Lysosomes

A

Small membrane bound sacs that contain lytic enzymes

Responsible for destroying and digesting proteins, carbohydrates, nucleic acids, and foreign particles

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19
Q

Peroxisomes

A

Contain peroxidases

Responsible for the production of hydrogen peroxide that is toxic to cells

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20
Q

Centrioles

A

Two cylindrical organelles near the nucleus

Responsible for separation of the chromosomes during mitosis and meiosis

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21
Q

Simple Diffusion

A

Movement from an area of high concentration to an area of low concentration, down a concentration gradient
No energy is required
no carrier molecule

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22
Q

Facilitated Diffusion

A

movement is down the concentration gradient and no energy is required - need carrier molecule
Molecules like glucose, potassium, and sodium use a carrier molecule to facilitate movement across the membrane

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23
Q

Osmosis

A

low to high
Passive process and no energy is required
when there is an unequal distribution of water on either side of a selectively permeable membrane

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24
Q

Osmotic pressure

A

force exerted on a selectively permeable membrane

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25
Filtration
Passive process whereby molecules are moved across the membrane because of greater pressure on the side where particles are leaving In the body filtration is powered by the blood pressure
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Isotonic
equal concentration of solutes (dissolved substances) and solvent (water) inside and outside cell; cell shape is maintained
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Hypotonic
higher concentration of water (lower concentration of solutes) outside cell; water moves into cell causing it to swell and eventually lyse
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Hypertonic
lower concentration of water (higher concentration of solutes) outside cell; water moves out of cell causing it to shrink or crenate
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Active Transport
``` Requires energy (ATP) and typically molecules move from an area of low concentration to an area of high concentration Requires a protein carrier (often called pumps) ```
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Endocytosis
Energy is required Cell membrane encloses a substance (to large for diffusion) outside of the cell forming a vesicle and then invaginates Phagocytosis = larger molecules brought into the cell Pinocytosis = liquid brought into the cell
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Exocytosis
Energy is required Opposite of endocytosis, the movement out of the cell a vesicle fuses with the plasma membrane as secretion (expulsion) occurs
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Transcytosis
Combination of endocytosis and exocytosis going on simultaneously
33
Apoptosis
Programmed cell death” Destroys cells that may have mutated and pose the danger of becoming a cancer It also helps to delete those immune cells that may recognize our own body as foreign Some specialized cells no longer go through the cell cycle Muscle cells Nerve cells
34
Interphase
About 90% of a cell’s life is spent in interphase
35
Major events during interphase | Replication of DNA
Before replication, the two strands of DNA are hydrogen bonded together Parental DNA strands unwind (hydrogen bonds are broken) New complimentary nucleotides pair with nucleotides in the parental DNA strands and DNA polymerase joins the new nucleotides When replication is complete, two identical double helix molecules have been formed Each strand of this double helix is equivalent to a chromatid
36
Prophase (before)
Chromatin is condensing to form chromosomes; each consists of two identical sister chromatids joined near the center by a centromere Centrioles move to opposite ends of the cell and spindle fibers attach the centrioles to the centromeres of each of the chromosomes
37
Metaphase (between)
Chromosomes line up at the middle of the cell along an imaginary line called the metaphase plate or equatorial plate
38
Anaphase (without)
Spindle fibers that attach the centromere to the centrioles shorten and drag the sister chromatids to opposite ends of the cell
39
Telophase (end)
Nuclear envelope starts to form around the chromosomes that start to unwind to form the threadlike chromatin
40
How many times can a cell replicate
zero to roughly 50-75 divisions
41
Labile cells
Ability to constantly divide | Skin cells, cells lining the gastrointestinal tract, and blood cells in the bone marrow
42
Stable cells
Divide when necessary | Hepatocytes (liver cells) have the ability to multiply when the liver is injured
43
Permanent cells
``` Do not have the ability to multiply A neuron (nerve cell) is an example of this type of cell ```
44
Necrosis
``` Pathological cell death Myocardial infarction (heart attack) results in the necrosis of cardiac muscle cells ```
45
Atoms
The smallest intact component of all matter The basic unit of an element that enters into a chemical combination Cannot be broken down into any simpler form of matter
46
3 main particles (subatomic particles):
Protons - positively charged (+) Neutrons - no charge Electrons - negatively charged (-)
47
Atomic Number
Number of protons in the nucleus of an atom (Positive charge) (Atomic Number = number of electrons) Number of protons (+) = Number of electrons (-) neutral charge
48
Mass Number
Total number of Protons + Neutrons in the nucleus (P + N) Atomic number + number of neutrons Number of neutrons = difference between the mass number and atomic number
49
Isotopes
Atoms that have the same Atomic Number but different Mass Number Atoms with the same number of Protons, but different number of Neutrons
50
Electron’s Energy Level
amount of energy required by an electron to stay in orbit Each shell can hold a maximum number of electrons This can be determined by the formula X = 2n2 X is the maximum number of electrons in energy number n n represents energy level / shell number 1st level - 2, 2nd level - 8 3rd level - 8 4th level - 2
51
Periodic Table
Elements are arranged in order of increasing atomic number from left to right Atomic number shown above the symbol Elements are arranged horizontally in rows called periods The vertical columns are called groups/families 1st smallest number is the atomic number the symbol is the atomic symbol the lowest number is the atomic mass
52
Element -
cannot be broken down into simpler substances even by a chemical reaction
53
Basic Categories on periodic table :
Metals Nonmetals Metalloid Noble Gases
54
Metals:
Chemical elements that are good conductor of both electricity and heat Exist as solids at room temperature (except mercury) Form cations and ionic bonds with non- metals Metals occupy the bulk of the periodic table
55
macronutrients
protein carbs, fats | Sodium (Na), Potassium (K), Magnesium (Mg), Calcium (Ca), Chloride (Cl)
56
micronutrients
minerals in the body | Iron (Fe), Cobalt (Co), Copper (Cu), Zinc (Zn), Fluoride (F
57
Non-metals:
Poor conductors of heat and electricity when compared to metals Exist as solids, liquids and gases at room temperature They form acidic oxides (whereas metals generally form basic oxides) Nonmetals – recevies electrons Metals-give off electrons
58
Metalloids:
diagonal separation of metals and non-metals Have properties of both metals and nonmetals Metalloids often behave as semiconductors Can carry an electric charge under special conditions This property makes metalloids useful in computers and calculators
59
Molecules
An electrically neutral group of at least two or more atoms | Can be of the same or different nonmetal elements – held together by covalent bonds
60
Proteins
Proteins are required for building and repair of body tissues Involved in structural support & bodily movement Can also be a source of energy made of amino acids contain Carbon, hydrogen, oxygen and nitrogen
61
Immunoglobulins –
Antibodies that defend the body against infectious agents Transport proteins – hemoglobin and myoglobin The structure of a protein determines its function
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amino acids
end products of protein digestion are amino acids Amino acids are joined together by peptide bonds between the carboxyl and amino groups (amine) Growth, repair and maintenance of all cells depends on amino acids The synthesis of body proteins, including plasma, intracellular and structural protein
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Primary protien
The sequence (linear) in which amino acids are lined up and connected by peptide bonds Dipeptide – Two amino acids combine Polypeptide – Many (> 3) amino acids combine The long repetitive sequence of amino acids that make a continuous chain is called the protein’s backbone
64
Secondary protein
Twisting or folding of the protein chain (primary) into a spiral or coil Called α helix; or parallel strands – called β pleated sheet Held by hydrogen bonds between the H of the NH of one amino acid and the O of the C=O of another amino acid
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Tertiary
Protein chains folded into specific three-dimensional shape held by: Hydrogen bonds Ionic bonds Disulfide bonds (-S-S- bonds) This shape is vital for the function of enzymes and the biological activity of other proteins
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Quaternary
noncovalent interactions Combination of several protein units (subunits) with its own complete structure Example – Hemoglobin
67
RNA- Ribonucleic acid
A chain of nucleotides produced by transcription of DNA Ribose C5H10O5 Single chain or strand The sugar is ribose and the base thymine is replaced by uracil Adenine is always bounded to Uracil RNA is made up of – nucleotides (with a nitrogenous base), a ribose sugar, and a phosphate group RNA – transfer information from DNA to the ribosome
68
Transcription of information
When a particular protein is needed by a cell – DNA chain separates One chain act as a template for RNA DNA sequence is enzymatically copied by an RNA polymerase to produce a complementary RNA (mRNA) In other words, the transfer of genetic information from DNA into RNA
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Codon
Grouping of three nucleotides on a mRNA molecule | Codes for one of the 20 natural amino acids
70
mRNA / messenger RNA
Contain/carry the information on the primary sequence of amino acids in a protein to be synthesized (in the cytoplasm)
71
tRNA / Transfer RNA
"reads" the mRNA codon by using its own anticodon carries the amino acid to be incorporated into the developing protein each tRNA is specific for a certain amino acid
72
rRNA / Ribosomal RNA
rRNA and protein combine to form a nucleoprotein called a ribosome Ribosome serves as the site and carries the enzyme necessary for protein synthesis
73
Carbohydrates
Major food source and energy supply for the body Stored in the liver and muscle as glycogen The primary way for cells to obtain energy is through the oxidation of carbohydrates – ATP Supply carbon for the synthesis of cell components Organic compounds containing only C, H and 0 Ratio of carbon, hydrogen and oxygen is 1:2:1 Functional groups - an aldehyde (aldose)---(O=CH) or ketone (ketose)----(O=C)
74
Citric Acid Cycle
Polysaccharides such as starch and glycogen are first hydrolyzed by enzymes to Glucose Glucose is transported by blood in animals and cell sap in plants Glucose is then oxidized to produce carbon dioxide and water Energy is released in this process which is used for functioning of the cells Energy can be extracted from carbohydrates, fats and when necessary, proteins
75
Reducing substances:
educe other compounds Must contain ketone or aldehyde group e.g. glucose, maltose, fructose , galactose and lactose Formation of Gylcosidic bond With other carbohydrates or non carbohydrates e.g. 2 sugar molecule
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Simple sugars
Monosaccharides Disaccharides Example: Sugar found in candy, jams and most desserts General formula: Cn(H2O)n n can be 3, 5 , 6 carbon atoms Glucose (C6H12O6) , fructose and galactose hexose sugars are the most abundant simple sugars and those most frequently found in food
77
Disaccharides
Combination of two simple sugars linked by a glycosidic bond (covalent bond) Involves the elimination of water, from the functional groups only Produce two monosaccharides when react with water Common disaccharides: Maltose ----- 2 D-glucose molecules Lactose------ glucose + galactose Sucrose------ glucose + fructose
78
Polysaccharides
Important polysaccharides Starch, glycogen, cellulose Starch Humans are able to metabolize Produced by plants for storage Cellulose Plant stems and leaves Humans are not able to metabolize
79
Glycogen
Composed of a large number of glucose units Humans store energy/glucose in the form of glycogen Stored in the liver and muscles
80
Lipids
Main biological function of lipids include energy storage Lipids are a class of hydrocarbon - containing organic compounds Contain the same elements as carbohydrates but with much less oxygen Part of cell membrane Precursor for steroid hormone
81
Lipids / (Fats)
hey are insoluble in water They are soluble in nonpolar organic solvents (such as ether and chloroform) Esters of long chain organic acids called fatty acids Fats are formed by the reaction of fatty acids and glycerol (alcohol) Glycerol occurs naturally in the body as a component of stored fat
82
most abundant lipids in the body
triglycerides - Consist of three molecules of fatty acids combined with a molecule of glycerol Only small amount of lipids in plasma Lipids with fatty acid: triglycerides Lipids without fatty acids: steroids
83
Saturated Fats
They tend to be solids and are referred to as fats | Fatty acids in these fats have single bonded carbons
84
Unsaturated Fats
They tend to be liquids and are called oils | Fatty acids in these fats have some double bonded carbons
85
Phospholipids
They form the major components of the cell membrane --- Phospholipids and glycolipids Form lipid bilayers Structure: Contain a phosphate group Esters of glycerol with two fatty acids and one phosphate-nitrogen compound
86
Free fatty acids
They are released when fats are broken down – hydrolysis of fat They are increased in conditions where sugar is not being used Low blood sugar; diabetes, starvation, etc
87
Steroids
Functions include: Form part of the cell membrane Form part of the bile salts which emulsify fats during digestion Form the ‘steroid’ hormones Cholesterol – Found in the cell membranes and transported in the blood Cortisol – Stress hormone Aldosterone – Regulates salt excretion Estrogen, progesterone and testosterone – sex hormones Unlike other lipids they are not esters
88
Cholesterol
Part of plasma membrane Made by the liver Supplied with food Must be bound to protein to be transported through the blood (LDL, HDL) Amphipathic molecule - Polar head, and a nonpolar tail Insoluble
89
LDLs
(low-density lipoproteins) – transport cholesterol from the liver to other cells of body Tends to deposit cholesterol on arterial walls
90
HDLs
(high-density lipoproteins) – removes cholesterol from dying cells and return it to the liver Carry cholesterol effectively and can dissolve cholesterol deposits in the arteries