sedatives and general anesthetics Flashcards Preview

MED 2042 Wks 6-12 > sedatives and general anesthetics > Flashcards

Flashcards in sedatives and general anesthetics Deck (18)
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1
Q

benzodiazepine MOA

A

bind to GABAa receptor
GABA agonists

(actually it facilitates GABA to stimulate the GABAa receptor cos it binds a different spot on the receptor)

cells becomes inhibited,
=inhibits feelings of anxiety

2
Q

benzodiazepine functions

A
reduce anxiety
produce sedation (calming) induce sleep
3
Q

midazolam

A

benzodiazepine

very short (
less than 6 hrs
conscious sedation

4
Q

temazepam

A

benzodiazepine

short (6-12 hrs)

put u to sleep, treat insomnia

5
Q

diazepam

A

benzodiazepine

long (>24 hrs)

manage anxiety, epilepsy, muscle relaxant

6
Q

thiopental/thiopentone

A

barbituate

very very very very short acting (10 mins) -gets distributed to other tissues

induction anaesthetic

7
Q
  • desfluorane / isoflurane / sevoflurane
    _ methoxyflurane
    – (nitrous oxide)
A

inhaled general anesthetic s

8
Q

inhaled general anesthetics MOA

A

block TREK-1 (K+) channel
oppose any tendency to excitation or depolarisation

(in AP, u get K+ channel opening alowing K efflux to bring cell back to resting membrane potential/prevent another excitation)

9
Q

inhaled general anesthetics properties

A

more lipid soluble=more potent

more lipid soluble=slower induction/recovery

10
Q

MAC (minimal alveolar conc)% is

A

potency

low numbers =high potency
e.g. 0.16=high potency vs 100

11
Q

blood:gas coefficient is

A

lipid solubility

high numbers=high potency
eg 12=hihgly soluble

12
Q

nitrous oxide properties

A

low blood:gas coefficient
low potency
fastest induction/recovery

13
Q

methoxyflurane properties

A

high blood:gas coefficient
high potency
slowest induction/recovery

14
Q

isoflurane
desflurane
sevoflurane

nitrous oxide

A

maintenance of

general anaesthesia

15
Q

methyoxyflurane

A

not used in 
gen anaes
more in just paramedics in a liquid form for u to breathe in

analgesia in subanaesthetic
doses

16
Q

iv general anaesthetics MOA

A

block NMDA channels

glutamate works at these channels

17
Q

ketamine

A

iv general anaesthetics

18
Q

propofol

A

iv general anaesthetics