Seizures/Epilepsy

Question 1

Phenobarbital Therapeutic Range

Answer 1

20 - 40 mcg/mL

Question 2

Phenobarbital

Answer 2

C-IV barbiturate
Produce tolerance, psychological dependence and physical dependence with prolonged use
Abrupt discontinuation can cause physiological withdrawal
Seizure risk is higher in patients being treated for seizures

Question 3

Carbamazepine Therapeutic Range

Answer 3

4 - 12 mcg/mL

Question 4

Carbamazepine

Answer 4

Tegretol

Aplastic anemia and agranulocytosis

Question 5

Divalproex and Valproic acid

Answer 5

Thrombocytopenia, weight gain, hair loss

Question 6

Fosphenytoin

Answer 6

IM injection

Prodrug of phenytoin, mixed with either NS or D5W

Question 7

Zonisamide

Answer 7

Allergic reaction in a patient with sulfa allergy
Weight loss
Decreased sweating
Kidney stones

Question 8

Topiramate

Answer 8

Decreased appetite, weight loss, angle closure glaucoma (increased IOP) and metabolic acidosis
Fetal harm, elevated ammonia levels, kidney stones

Question 9

Phenytoin

Answer 9

Hirsutism, gingival hyperplasia

Osteoporosis, hepatotoxicity and peripheral neuropathy