sensory system

Question 1

sensory system

Answer 1

Information about changes in the external and
internal environment of an organism is conveyed to
the CNS and endocrine by the sense organ.

Question 2

sense organs

Answer 2

Based on stimulus modality, sense organs
are organized into the following types:
1. CHEMORECEPTORS that respond to
chemicals including odour, taste, etc.
2. THERMORECEPTORS responding to heat
and cold.
3. NOCICEPTORS or Pain receptors
4. MECHANORECEPTORS that respond to
touch, pressure, stretch etc
5. PHOTORECEPTORS enabling vision.

Question 3

based on origin of stumuli divided into

Answer 3

Interoceptors detect stimuli orginating in
the internal organs and parts of the body,
e.g. pain, nausea, pressure etc.
* Proprioceptor sense the position and
movements of the body.
* Exteroceptors sense stimuli of external
origin.

Question 4

sensory system contains

Answer 4

Sensory receptors: Receive stimuli from the external or internal environment,

The neural pathways: Conduct information from the receptors to the brain or
spinal cord, and

those parts of the brain that deal primarily with processing the information.

Question 5

sensation

Answer 5

The Information that a sensory system processes lead to conscious
awareness of the stimulus

Question 6

sensory information

Answer 6

The Information that a sensory system processes but does not lead to
conscious awareness of the stimulus

Question 7

perception

Answer 7

A person’s awareness of the sensation (and, typically, understanding of its
meaning)

Question 8

sensory receptors

Answer 8

Sensory receptors at the peripheral ends of afferent
neurons change this information into graded potentials that
can initiate action potentials, which travel into the central
nervous system.

The receptors are either specialized endings of the primary
afferent neurons themselves ( Figure 7.1a ) or separate
receptor cells (some of which are actually specialized
neurons) that signal the primary afferent neurons by
releasing neurotransmitters
Most sensory receptors are exquisitely sensitive to their
specific adequate stimulus but all sensory receptors can
be activated by different types of stimuli if the intensity
is sufficient

Question 9

receptor potential magnitude varies

Answer 9

Receptor potential magnitude varies with

Stimulus strength,

Rate of change of stimulus application,

Temporal summation of successive receptor potentials,

Adaptation: decrease in receptor sensitivity

Question 10

coding

Answer 10

Coding is the conversion of stimulus energy into a signal that conveys the relevant sensory information to the central nervous system

Question 11

charactersistics of stimulus depends on

Answer 11

Type of input it represents,

Its intensity, and

The location of the body it affects

Question 12

sensory unit

Answer 12

A single afferent neuron with all its receptor
endings

Question 13

receptive field

Answer 13

The area of the body that leads to activity
in a particular afferent neuron when stimulated
Receptive fields of neighboring afferent neurons usually overlap

Question 14

stimulus types/ stimulus modality

Answer 14

Stimulus Type/ Stimulus modality: for example heat,
cold, sound, or pressure

Modalities can be divided into submodalities. for
example

Cold and warm are submodalities of temperature,

salty, sweet, bitter, and sour are submodalities of taste

All the receptors of a single afferent neuron are
preferentially sensitive to the same type of stimulus

for example, they are all sensitive to cold or all to
pressure

Question 15

stimulus intensty

Answer 15

Stimulus intensity is coded by the rate of firing of
individual sensory units (frequency) and by the number
of sensory units activated.

Sensory receptor potential amplitude tends to be
graded according to the size of the stimulus applied,
but action potential amplitude does not change with
stimulus intensity.

Increasing stimulus intensity is encoded by the
activation of increasing numbers of sensory neurons
(recruitment)

Resultant, increase in the frequency of action potentials
propagated along sensory pathways.

Question 16

stimulus location

Answer 16

Stimuli of a given modality from a particular region of the body
generally travel along dedicated, specific neural pathways to
the brain, referred to as labeled lines.

The acuity with which a stimulus can be localized depends on
the size and density of receptive fields in each body region.

The greater the convergence, the less the acuity.

Other factors affecting acuity are

the size of the receptive field covered by a single sensory unit ( Figure
7.6a ), the density of sensory units,

And the amount of overlap in nearby receptive fields.

A synaptic processing mechanism called lateral inhibition
enhances localization as sensory signals travel through the CNS.

Most specific ascending pathways synapse in the thalamus on the
way to the cerebral cortex after crossing the midline, such that
sensory information from the right side of the body is generally
processed on the left side of the brain, and vice versa.

Question 17

lateral inhibito

Answer 17

In lateral inhibition, information from afferent neurons
whose receptors are at the edge of a stimulus is strongly
inhibited compared to information from the stimulus’s
center

Question 18

Central Control of Afferent
Information

Answer 18

Information coming into the nervous system is subject
to modification by both ascending and descending
pathways.

Inhibition from collaterals from other ascending neurons
(e.g., lateral inhibition)

Inhibitory pathways descending from higher centers in the
brain (reticular formation and cerebral Cortex)

Question 19

ascending pathway

Answer 19

Sensory pathways are also called ascending pathways
because they project “up” to the brain.
The central processes of the afferent neurons enter the
brain or spinal cord and synapse upon interneurons, where
they either converge or diverge

Question 20

sensory pathways

Answer 20

Sensory pathways are generally formed by chains of three
or more neurons connected by synapses

Afferent neurons

Second-order neurons

Third-order neurons

Question 21

types of acending pathway

Answer 21

Types:

specific ascending pathways

Non-specific ascending pathways

Question 22

specific ascending pathways and there processing center

Answer 22

Somatic receptors (skin,
skeletal muscle, bones,
tendons, and joints)= somatosensory cortex in
the parietal lobe

the eyes= visual cortex , in the
occipital lobe.

the ears= auditory cortex , in the
temporal lobe

from the taste buds= gustatory cortex adjacent
to the region of the
somatosensory cortex

Question 23

non specific ascending pathways

Answer 23

Nonspecific ascending pathways convey information
from more than one type of sensory unit to the
brainstem reticular formation and regions of the
thalamus that are not part of the specific ascending
pathways.

They indicate that something is happening, without
specifying just what or where

For example, to input from several afferent neurons,
each activated by a different stimulus, such as
maintained skin pressure, heating, and cooling. Such
pathway neurons are called polymodal neurons

Question 24

Association Cortex and
Perceptual Processing

Answer 24

Information from the primary sensory cortical areas is
elaborated after it is relayed to a cortical association
area

The primary sensory cortical area and the region of
association cortex closest to it process the information
in fairly simple ways and serve basic sensory-related
functions.

Regions of association cortex farther from the primary
sensory areas process the sensory information in more
complicated ways.

Processing in the association cortex includes input from
areas of the brain serving other sensory modalities,
arousal, attention, memory, language, and emotions.

Question 25

factors that affect perception

Answer 25

Sensory receptor mechanisms (e.g., adaptation) and processing of the information along afferent pathways Factors such as emotions, personality, experience, and social background Not all information entering the central nervous system gives rise to conscious sensation e.g., the ear can detect vibrations having a smaller amplitude We lack suitable receptors for many types of potential stimuli. E.g., we cannot directly detect ionizing radiation or radio waves Damaged neural networks may give faulty perceptions as in the phenomenon known as phantom limb Some drugs alter perceptions Various types of mental illness

Question 26

somatic sensation

Answer 26

A variety of receptors sensitive to one or a few stimulus types provide sensory function of the skin and underlying tissues. Information about somatic sensation enters both specific and nonspecific ascending pathways. The specific pathways cross to the opposite side of the brain. The somatic sensations include touch, pressure, the senses of posture and movement, temperature, and pain.

Question 27

touch and pressure

Answer 27

pressure: Rapidly adapting mechanoreceptors of the skin give rise to sensations such as vibration, touch, and movement, whereas slowly adapting ones give rise to the sensation of pressure. Skin receptors with small receptive fields are involved in fine spatial discrimination, whereas receptors with larger receptive fields signal less spatially precise touch or pressure sensations(fig. 7.15) A major receptor type responsible for the senses of posture and kinesthesia (sense of movement at a joint) is the muscle-spindle stretch receptor.

Question 28

temperature

Answer 28

Cold receptors are sensitive to decreasing temperature; warmth receptors signal information about increasing temperature Afferent neurons with little or no myelination They lack the elaborate capsular endings Temperature sensors are ion channels in the plasma membranes of the axon terminals that belong to a family of proteins called transient receptor potential ( TRP ) proteins Different isoforms of TRP channels have gates that open in different temperature ranges, resulting Na influx and receptor potential generation TRP proteins can be opened by chemical ligands. For example, capsaicin and ethanol are perceived as hot and cold respectively

Question 29

pain

Answer 29

Stimuli that cause tissue damage elicit a sensation of pain, Receptors for such stimuli are known as nociceptors Nociceptors (like termoreceptor) respond to intense mechanical deformation, extremes of temperature, and many chemicals (H+ ,neuropeptide transmitters, bradykinin, histamine, cytokines, and prostaglandins, several of which are released by damaged cells) Afferents having nociceptor endings synapse on ascending neurons after entering the central nervous system which secret glutamate and the neuropeptide and substance P as neurotransmiter

Question 30

refered pain

Answer 30

When incoming nociceptive afferents activate interneurons, the sensation of pain is experienced at a site other than the injured or diseased tissue e.g., during a heart attack feeling of pain in left arm Series of changes can occur in components of the pain pathway— including the ion channels in the nociceptors themselves—that alters the way these components respond to subsequent stimuli

Question 31

hyperaglesia

Answer 31

An increased sensitivity to painful stimuli

Question 32

aglesia

Answer 32

Analgesia is the selective suppression of pain without effects on consciousness or other sensations.

Question 33

stimulation produced aglesia

Answer 33

Electrical stimulation of specific areas of the central nervous system can produce a profound reduction in pain because descending pathways that originate in these brain areas selectively inhibit the transmission of information originating in nociceptors (Figure 7.16b) e.g., morphine like endogenous opioids and acupuncture

Question 34

Transcutaneous electrical nerve stimulation

Answer 34

the painful site itself or the nerves leading from it are stimulated by electrodes placed on the surface of then

Question 35

normal pathway of somatic sensory system

Answer 35

Specific ascending pathways projecting primarily to the somatosensory cortex via the brainstem and thalamus. They also synapse on interneurons that give rise to the nonspecific ascending pathways There are two major types of somatosensory pathways from the body; Ascending anterolateral pathway Dorsal column pathway Both pathways cross from the side where the afferent neurons enter the central nervous system to the opposite side either in the spinal cord (anterolateral system) or in the brainstem (dorsal column system)

Question 36

vision -eyes

Answer 36

Eyes: Perceiving a visual signal—capable of focusing and responding to light, and the appropriate neural pathways and structures to interpret the signal

Question 37

light and vision

Answer 37

The color of light is defined by its wavelength or frequency. The light that falls on the retina is focused by the cornea and lens. Lens shape changes (accommodation) to permit viewing near or distant images so that they are focused on the retina. Stiffening of the lens with aging interferes with accommodation. Cataracts decrease the amount of light transmitted through the lens. An eyeball too long or too short relative to the focusing power of the lens and cornea causes nearsighted (myopic) or farsighted (hyperopic) vision, respectively.

Question 38

presbyopia

Answer 38

Presbyopia: decline in the ability to accommodate for near vision

Question 39

cataracts

Answer 39

Cataracts: an opacity (clouding) of the lens associated with smoking and diseases such as diabetes

Question 40

astigmatism

Answer 40

Astigmatism: the lens or cornea does not have a smoothly spherical surface

Question 41

galucoma

Answer 41

Glaucoma: increased pressure within the eye

Question 42

pupil size

Answer 42

Pupil size: Miosis: narrow pupil size Mydriasis: wide pupil size

Question 43

retina

Answer 43

Retina: consist of photoreceptors and several other cell types that function in the transduction of light waves into visual information

Question 44

photoreceptor

Answer 44

Photoreceptor: outer segment + inner segment Types: rods and cones photoreceptors contain molecules called photopigments e.g., Rhodopsin for the rods, and distinct photopigments for 3 types of cons Photopigments: membrane-bound proteins called opsins bound to a chromophore molecule(retinal). The photopigments vary with respect of opsin (absorb different wave length of light)

Question 45

in absence of light

Answer 45

In the absence of light, action of the enzyme guanylyl cyclase converts GTP into cGMP which maintain ligand-gated cation channels in an open state, and allow influx of Na+ and Ca 2+ results

Question 46

in presence of light

Answer 46

In the presence of light, the opsin protein shape alters and promotes an interaction between the opsin and a protein called transducin which activates cGMP- phosphodiesterase, which rapidly degrades cGMP ligand-gated cation channels get closed (hyperpolarization)

Question 47

dark adaption

Answer 47

Dark adaptation: When someone entered from bright sunlight into a darkened room, a temporary “blindness” takes place.

Question 48

light adaption

Answer 48

Light adaptation: When someone step from a dark place into a bright one. Initially, the eye is extremely sensitive to light as rods are overwhelmingly activated, and the visual image is too bright and has poor contrast.

Question 49

photopigments

Answer 49

The photopigments of the rods and cones are made up of a protein component (opsin) and a chromophore (retinal). The rods and each of the three cone types have different opsins, which make each of the four receptor types sensitive to different ranges of light wavelengths. When light strikes retinal, it changes shape, triggering a cascade of events leading to hyperpolarization of photoreceptors and decreased neurotransmitter release from them. When exposed to darkness, the rods and cones are depolarized and therefore release more neurotransmitter than in light.

Question 50

neural pathway of vision

Answer 50

The rods and cones synapse on bipolar cells, which synapse on ganglion cells. Ganglion cell axons form the optic nerves, which exit the eyeballs. The optic nerve fibers from the medial half of each retina cross to the opposite side of the brain in the optic chiasm. The fibers from the optic nerves terminate in the lateral geniculate nuclei of the thalamus, which sends fibers to the visual cortex. Photoreceptors also send information to areas of the brain dealing with biological rhythms. Coding in the visual system occurs along parallel pathways in which different aspects of visual information, such as color, form, movement, and depth, are kept separate from each other.

Question 51

color vision

Answer 51

The colors we perceive are related to the wavelength of light. The three cone photopigments vary in the strength of their response to light over differing ranges of wavelengths Certain ganglion cells are excited by input from one type of cone cell and inhibited by input from a different cone type. Our sensation of color depends on the output of the various opponent color cells and the processing of this output by brain areas involved in color vision. Color blindness is due to abnormalities of the cone pigments resulting from genetic mutations.

Question 52

color blindness

Answer 52

There are several types of defects in color vision that result from mutations in the cone pigments. The most common form of color blindness , red–green color blindness Predominant in men (1 out of 12) and rare in women (1 out of 200) Color blindness results from a recessive mutation in one or more genes encoding the cone pigments.

Question 53

eye movement

Answer 53

Six skeletal muscles control eye movement to scan the visual field for objects of interest, keep the fixation point focused on the fovea centralis despite movements of the object or the head, and prevent adaptation of the photoreceptors.

Question 54

hearing

Answer 54

Sound energy is transmitted by movements of pressure waves. a. Sound wave frequency determines pitch. b. Sound wave amplitude determines loudness. Humans audible hearing limits (keen hearing) 1000-4000 Hz Range of frequencies audible to human (20 to 20,000 Hz).

Question 55

sequence of sound transmission

Answer 55

Sound waves enter the external auditory canal and press against the tympanic membrane, causing it to vibrate. The vibrating membrane causes movement of the three small middle ear bones; the stapes vibrates against the oval window membrane. Movements of the oval window membrane set up pressure waves in the fluid-filled scala vestibuli, which cause vibrations in the cochlear duct wall, setting up pressure waves in the fluid there. These pressure waves cause vibrations in the basilar membrane, which is located on one side of the cochlear duct. As this membrane vibrates, the hair cells of the organ of Corti move in relation to the tectorial membrane. Movement of the hair cells’ stereocilia stimulates the hair cells to release glutamate, which activates receptors on the peripheral ends of the afferent nerve fibers. Separate parts of the basilar membrane vibrate maximally in response to particular sound frequencies; high frequency is detected near the oval window Low frequency toward the far end of the cochlear duct.

Question 56

vestibular system

Answer 56

Vestibular apparatus: connected series of endolymph-filled, membranous tubes that also connect with the cochlear duct The hair cells detect changes in the motion and position of the head by a stereocilia transduction mechanism The vestibular apparatus consists of three membranous semicircular canals and two saclike swellings, the utricle and saccule Housed in tunnels in the temporal bone on each side of the head The semicircular canals detect angular acceleration during rotation of the head along three perpendicular axes The utricle and saccule (see Figure 7.42 ) provide information about linear acceleration of the head, and about changes in head position relative to the forces of gravity

Question 57

chemica senses

Answer 57

Chemoreceptors: The receptors sensitive to specific chemicals, They respond to chemical changes in their environment; Internal: two examples are receptors that sense oxygen and hydrogen ion concentration in the blood External: the receptors for taste and smell, which affect a person’s appetite, saliva flow, gastric secretions, and avoidance of harmful substances

Question 58

taste

Answer 58

Taste Buds: 10,000 or so taste buds found in the mouth and throat, the vast majority on the upper surface and sides of the tongue Taste buds are small groups of cells arranged like orange slices around a hollow pore and are found in the walls of visible structures called lingual papillae( Figure 7.47 ). Some of the cells serve mainly as supporting cells, but others are specialized epithelial cells that act as receptors for various chemicals in the food we eat. Hair-like microvilli: increase the surface area of taste receptor cells and contain integral membrane proteins that transduce the presence of a given chemical into a receptor potential. At the bottom of taste buds are basal cells, which divide and differentiate to continually replace taste receptor cells damaged in the occasionally harsh environment of the mouth. To enter the pores of the taste buds and come into contact with taste receptor cells, food molecules must be dissolved in liquid

Question 59

taste receptors

Answer 59

Many different chemicals can generate the sensation of taste by differentially activating a few basic types of taste receptors Taste sub-modalities generally fall into five different categories according to the receptor type most strongly activated; sweet, sour, salty, bitter, and umami (yet others to be discovered) Each group of tastes has a distinct signal transduction mechanism

Question 60

salt taste

Answer 60

is detected by entering sodium ions in the receptor cell membrane channels, depolarizing the cell and stimulating the production of action potentials in the associated sensory neuron.

Question 61

sweet taste

Answer 61

Sweet receptors have integral membrane. Binding of sugars to these receptors activates a G-protein-coupled second-messenger pathway that ultimately blocks K+ channels and thus generates a depolarizing receptor potential.

Question 62

sour taste

Answer 62

Sour taste is stimulated by foods with high acid content. Hydrogen ions block K+ channels in the sour receptors, and the loss of the hyperpolarizing K+ leak current depolarizes the receptor cell.

Question 63

bitter

Answer 63

Bitter flavor there are many varieties of bitter receptors. All of those types, however, generate receptor potentials via G-protein-mediated second-messenger pathways and ultimately evoke the negative sensation of bitter flavor.

Question 64

umami

Answer 64

Umami receptor cells also depolarize via a G-protein-coupled receptor mechanism

Question 65

smell

Answer 65

Sense of smell (olfaction): The olfactory receptor(chemoreceptors) perceive the odour of thousands of chemical with perfect accuracy Location: a small patch of epithelium called the olfactory epithelium in the upper part of the nasal cavity Olfactory receptor neurons survive for only about 2 months Specialized afferent neurons that have a single, enlarged dendrite that extends to the surface of the epithelium Several long, nonmotile cilia extend from the tip of the dendrite and lie along the surface of the olfactory epithelium The cilia contain the receptor proteins that provide the binding sites for odor molecules The axons of the neurons form the olfactory nerve, which is cranial nerve I

Question 66

factors affecting olfaction

Answer 66

Factor affecting Olfaction: Hunger: Sensitivity is greater in hungry subjects Gender: Women in general have keener olfactory sensitivities than men Smoking: Decreased sensitivity has been repeatedly associated with smoking Age: The ability to identify odors decreases with age State of the olfactory mucosa: The sense of smell decreases when the mucosa is congested, as in a head cold Genetic: Genetic defects resulting in a total lack of the ability to smell ( anosmia). For example, defects in genes on the X chromosome, as well as in chromosomes 8 and 20, can cause Kallmann syndrome. This is a condition in which the olfactory bulbs fail to form, as do regions of the brain associated with regulation of sex hormones.