Sepsis Flashcards
(17 cards)
Clinical syndrome defined as life threatening organ dysfunction due to dysregulated host response to infection.
Sepsis
How is SIRs characterised?
Temperature
Heart rate
Respiratory rate and
WBC count
How is septic shock characterised?
Sepsis with circulatory and cellular metabolism dysfunction.
Hypotension that requires vasopressor support.
What are the Clinical signs of sepsis?
Can range widely.
Lethargy, innapetance, V+…. Up to organ failure and decompensatory shock.
What is the Sepsis criteria in cats?
HRT < 140 > 225
RR > 40
Increased WBC count
What is the sepsis criteria for dogs?
HRT > 120
RR > 20
High WBC count
What are the common types of organ function associated with Sepsis?
AKI
GI signs in Dogs
ALI
ARDs
How many organs are affected in MOD?
2 or more.
What is damaged in sepsis that exacerbates coagulation activation and dysregulation?
Damage to the glycocalyx and the endothelium.
What clinicopathological abnormalities may be seen with sepsis?
Hyperlactataemia
Neutophillic leukocytosis
Dysregulation of coagulation
Hyper/Hypoalbuminrmia
Hypotension
Compromises endothelial function
Four common clinocopathological changes in routine lab work with sepsis include?
Hypo/hyperglycaemia.
Hypoalbuminaemia.
Hyoerbilirubinemia.
Ionised hypocalcaemia.
What values compared to peripheral blood is highly suggestive of septic peritonitis?
Lactate > 2 mmol/l
Glucose < 20 mg/dL
What drug is usually used as a first line vasopressor for septic patients?
Norepinephrine.
What drug/s are indicated if cardiac contractility is reduced?
Dobutamine CRI
Digoxin
Pumbobemdan
Why is Etomidate controversial in sepsis cases?
Effect on adrenal function and increased patient morbidity and mortality.
Ketamine supports the cardiopulmonary systems. In sepsis, what condition may it help prevent?
ARDs.
