Serologic Studies/Associations

Question 1

ANA

Answer 1

SLE, SSc, Sjogren syndrome; titer does not correlate with disease activity

Question 2

Anti-Sm

Answer 2

SLE; most specific for SLE but does not correlate with disease activity

Question 3

Anti-U1-RNP

Answer 3

Mixed connective tissue disease (MCTD) –> rare, so it is a “unique 1”. Pulmonary arterial hypertension and interstitial lung disease are associated with premature mortality.

Question 4

Anticentromere pattern of DNA

Answer 4

CREST syndrome; SSc and PH

Question 5

Anti-dsDNA antibody

Answer 5

SLE; correlates with disease activity, especially kidney disease

Question 6

Anti-smooth muscle antibody

Answer 6

Autoimmune hepatitis

Question 7

Anti-La/SSB antibody

Answer 7

Sjogren syndrome, neonatal SLE

Question 8

Anti-Scl-70 antibody

Answer 8

SSc and pulmonary fibrosis/diffuse cutaneous SSc

Question 9

Antihistone antibody

Answer 9

Drug-induced SLE

Question 10

Anti-Ro/SSA antibody

Answer 10

Sjogren syndrome, neonatal heart block, subacute cutaneous lupus

Question 11

c-ANCA (anti-PR3 antibody)

Answer 11

Granulomatosis with polyangiitis

Question 12

p-ANCA (anti-MPO antibody)

Answer 12

Eosinophilic granulomatosis with polyangiitis and MPA

Question 13

Anti-Jo-1 antibody

Answer 13

polymyositis and antisynthetase syndrome (ILD, myositis, Raynaud phenomenon, non erosive inflamm arthritis, low grade fever, mechanic’s hands)

Question 14

Anti-CCP antibody

Answer 14

Rheumatoid arthritis