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Flashcards in Serology Rationale 1 Deck (35):
1

Discovery of the T cell receptor gene:
a. 1978
b. 1880
c. 1901
d. 1984

d. 1984

2

All of the following are correct match, except:
a. Ellie Metchnikoff: Phagocytosis
b. Koehler, Millstein: Monoclonal antibodies
c. Snell, Dausset, Benaceraf: MHC
d. Thomas, Murray: RIA

d. Thomas, Murray: RIA

Rosalyn Yalow: RIA

3

In searching for a cure for TB, Koch was first to observe which phenomenon?
a. Bacterial agglutination
b. Precipitation
c. Phagocytosis
d. Delayed hypersensitivity

d. Delayed hypersensitivity

4

Chronic granulomatous disease represents a defect of:
a. Oxidative metabolism
b. Abnormal granulation of neutrophils
c. Diapedesis
d. Chemotaxis

a. Oxidative metabolism

5

A primary function of the eosinophil is:
a. Phagocytosis
b. Reacting in acute, systemic hypersensitivity reactions
c. Suppression of the inflammatory response
d. Antigen recognition

c. Suppression of the inflammatory response

6

Protein(s) that are released by eosinophils and are toxic to helminthes is(are):
a. Major basic protein
b. Eosinophil cationic protein
c. Perforin
d. Both A and B

d. Both A and B

Major basic protein and Eosinophil cationic protein

7

Of the circulating lymphocytes in peripheral blood, which are in the greatest percentages?
a. NK cells
b. Null lymphocytes
c. B lymphocytes
d. T lymphocytes

d. T lymphocytes

8

Large granular lymphocytes (LGL) is synonymous with:
a. B cell
b. T helper cell
c. T cytotoxic cell
d. NK cells

d. NK cells

9

The major role of NK cells is lysis of virally infected cells. Which one of the following molecules is released by activated NK cells and causes destruction of the infected cell?
a, Major basic protein
b. Superoxide
c. Perforin
d. Lysozyme

c. Perforin

10

The major role of neutrophils is phagocytosis. Which one of the following events is not associated with some aspect of neutrophil function?
a. Recognition of antigen via primitive pattern receptor patterns
b. Recognition of opsonins on bacteria
c. Secretion of perforin
d. Activation of the NADPH oxidase

c. Secretion of perforin

11

A cut on person's fingers becomes contaminated with the bacterium Staphylococcus aureus. The first response by the immune system consists of the activity of:
a. B cells
b. Monocytes
c. Neutrophils
d. T cells

c. Neutrophils

12

Monocytes and macrophages plays a role in the mononuclear phagocytic system. For an antibody-coated antigen to be phagocytised, what part of the antibody molecule fits into a receptor on the phagocytic cell?
a. Fc region
b. Fab region
c. Hinge region
d. Variable region

a. Fc region

13

A function of the cell mediated immune response not associated with humoral immunity is:
a. Defense against viral and bacterial infection
b. Defense against fungal and bacterial infection
c. Initiation of rejection of foreign tissues and tumors
d. Antibody production

c. Initiation of rejection of foreign tissues and tumors

14

The major role of cytotoxic T cells and NK cells is to destroy:
a. Extracellular bacteria
b. Intracellular bacteria
c. Virally infected cell
d. Helminthes

c. Virally infected cells

15

Which on of the following cells recognizes a cell surface complex consisting of antigenic peptide complexed with MHC protein?
a. Phagocytes
b. Eosinophils
c. T cells
d. B cells

c. T cells

16

An individual recovering from a bacterial infection and tests positive for antibodies to a protein normally found in the cytoplasm of this bacterium. Which of the following statements is true of this situation?
a. Class I molecules have presented bacterial antigen to CD8+ T cells
b. Class I molecules have presented bacterial antigen to CD4+ T cells
c. Class II molecules have presented bacterial antigen to CD4+ T cells
d. B cells have recognized bacterial antigen without help from T cells

c. Class II molecules have presented bacterial antigen to CD4+ T cells

17

A living donor is being sought for a child who requires kidney transplant. The best odds of finding an MHC compatible donor occur between the child and:
a. Sibling (brother or sister)
b. An unrelated individual
c. The child's father
d. The child's mother

a. Sibling (brother or sister) - 50% chance

18

The following phenotypes resulted from blood typing a mother, 6-month-old baby and alleged father in a case of paternity testing.

ABO>Rh>HLA
Mother; A; ce; A2,A29,B12,B17
Baby; O; ce; A2,A3,B12,B15
Alleged father; A; DCce; A3,A9,B5,B7

Which of the following statements is true? The alleged father:
a. Is excluded by the ABO system
b. Is excluded by the Rh system
c. Is excluded by the HLA system
d. Cannot be ruled out

c. Is excluded by the HLA system

19

Which of the following is a potent mediator in acute-phase response?
a. IL-1
b. IL-2
c. IL-3
d. IL-4

a. IL-1

20

Which of the following enhances the cytolytic activity of lymphokine-activated killer cells (LAK)?
a. IL-1
b. IL-2
c. IL-3
d. IL-4

b. IL-2

21

Which of the following are target cells for IL-3?
a, Myeloid precursors
b. Lymphoid precursors
c. Erythroid precursors
d. AOTA

d. AOTA

Myeloid precursors, Lymphoid precursors, Erythroid precursors

22

Flow cytometry results on a patient reveal a lack of cells with CD2 and CD3. What does this indicate?
a. Lack of B cells
b. Lack of T cells
c. Lack of Monocytes
d. Lack of NK cells

b. Lack of T cells

23

Which cell surface marker is termed the common acute lymphoblastic leukemia marker?
a. CD19
b. CD10
c. CD23
d. CD21

b. CD10

24

Which of the following activates both T and B cells?
a. PHA
b. Con A
c. LPS
d. PWM

d. PWM

Pokeweed mitogen

25

CRP is synthesized in the:
a. Bone marrow
b. Lymphatics
c. RES
d. Epithelial cells

c. RES

26

Measurement of CRP levels can be used for all of the following except:
a. Monitoring drug therapy with anti-inflammatory agents
b. Tracking the normal progress of surgery
c. Diagnosis of a specific bacterial infection
d. Determining active phases of rheumatoid arthritis

c. Diagnosis of a specific bacterial infection

27

Actively acquired immunity can be caused by all of the following, except:
a. The specific disease
b. Exposure to subclinical doses of the disease-causing organism
c. Vaccination with immune serum containing appropriate antibodies
d. Infection with immune serum containing appropriate antibodies

d. Infection with immune serum containing appropriate antibodies

28

The type of immunity that follows the injection of antibodies synthesized by another individual or animal is termed:
a. artificial active
b. natural adaptive
c. artificial passive
d. natural passive

c. artificial passive

29

A major advantage of passive immunization compared to active immunization is that:
a. Antibody is available more quickly
b. IgM is the predominant antibody class provided
c. Antibody persists for the life of the recipient
d. Oral administration can be used

a. Antibody is available more quickly

30

A hapten is:
a, Half of an immunoglobulin molecule
b. A earner molecule for an antigen that is not antigenic alone
c. An immunoglobulin functional only in the presence of complement
d. A determinant capable of stimulating an immune response only when bound to a carrier

d. A determinant capable of stimulating an immune response only when bound to a carrier

31

The specific region of the antigen that binds to the antigen-binding site receptors is termed an:
a. Epitope
b. Paratope
c. Antibody determinant
d. Idiotype

a. Epitope

32

An epitope is also termed a/an:
a. Binding site
b. Allotype
c. Antigenic determinant
d. Immunogen

c. Antigenic determinant

33

Identical antibodies produced from a single clone of plasma cells describes:
a. Reagin
b. Cold agglutinins
c. Heterophile antibodies
d. Monocal antibodies

d. Monoclonal antibodies

34

Monoclonal antibodies are produced by:
a. Cultured T cells
b. Human plasma cells
c. Mouse plasma cells
d. Hybridomas

d. Hybridomas

35

Formation of hybridoma in monoclonal antibody production
1. Spleen cells are fused with myeloma cells and then plated in restrictive medium
2. A mouse is immunized, and spleen cells are removed
3. Hybridoma cells grow in the HAT medium, where they synthesize and secrete a monoclonal immunoglobulin specific for a single determinant on an antigen
a. 1-2-3
b. 2-1-3
c. 3-1-2
d. 3-2-1

b. 2-1-3

A mouse is immunized, and spleen cells are removed

Spleen cells are fused with myeloma cells and then plated in restrictive medium

Hybridoma cells grow in the HAT medium, where they synthesize and secrete a monoclonal immunoglobulin specific for a single determinant on an antigen