Serotonin

Question 1

Lysergic acid diethylamide

Answer 1

Relatively nonspecific - 5HT2 receptors
LSD
Partial or full agonist at 5HT2 receptors
Potency hallucinogen (50 microgram)
Only 1% gets into brain (few nanograms give hallucination)

Question 2

Buspirone

Answer 2

5-HT1A receptor partial agonist

Antianxiety

Question 3

Sumatriptan

Answer 3

5 HT 1D and 1B receptor agonists on cerebral blood vessels
Treat migraines and stop existing ones
Inhibit release of vasoactive peptides- calcitonin gene related peptide -CGRP
Promote vasoconstriction
Side effects: nausea, vomiting, angina, dizziness, and flushing

Question 4

Tegaserod (Zelnorm)

Answer 4

5-HT4 partial agonist 
Release other enteric NT
Normalizes impaired intestinal motility 
Stimulates intestinal secretion 
For irritable bowel syndrome with constipation in women 
Taken off market due to CV effects

Question 5

Locaserin

Answer 5

Approved for use in treatment of obsesity with adults with BMI greater than 30 or BMI greater than 27 who have at least one weight related health condition like high BP, Type 2 diabetes, high cholesterol
Selective 5-HT 2c receptor agonist–> activation in hypothalamus activates proopiomelanocortin (POMC) production and consequently promote weight loss through satiety
IV drug

Question 6

Indirect Agonists

Answer 6

SSRI
MOA inhibitors
SNRI

Question 7

SSRI (Fluoxetine and Duloxetine)

Answer 7

Increase amount of NT in synapse
Treatment: major depressive disorder, OCD, panic attacks
Side effects: sexual dysfunction, nausea

Question 8

Monoamine oxidase inhibitor

Answer 8

Phenelzine
Block metabolism of serotonin, NE and DA
Increase synaptic serotonin
Treatment of major depressive disorder and narcolepsy
Side effect is food induced hypertensive crisis

Question 9

SNRI

Answer 9

Duloxetine
Block reuptake of serotonin and NE into neurons
Use: Major depressive disorder and pain

Question 10

Serotonin Antagonists

Answer 10

Cyproheptadine
Odansetron
Alosetron

Question 11

Cyproheptadine

Answer 11

5-HT 2 antagonist and H1 histamine antagonist

Treatment for allergies, pruritis and urticaria and carcinoid

Question 12

Odansetron

Answer 12

5-HT3 antagonists
Treatment of chemotherapy induced nausea and vomiting, post-op and X-Ray therapy induced nausea and vomiting
CNS and GI action
Atypical antipsychotic drugs block 5-HT2 receptors in addition to dopamine receptors
IV, oral and transdermal forms available

Question 13

Alosetron

Answer 13

Selective 5-HT3 antagonist
Treat diarrhea predominant IBS in women who failed to respond to conventional therapy
Produce severe GI affects like infarcts
Restricted prescribing program

Question 14

Serotonin Agonists

Answer 14

Lysergic acid diethylamide
Buspirone
Sumatriptan

Question 15

Duloxetine

Answer 15

Blocks active reuptake of both serotonin and norepinephrine into neurons
Indicated for major depressive disorder and neuropathic pain

Question 16

Duloxetine

Answer 16

Blocks active reuptake of both serotonin and norepinephrine into neurons
Indicated for major depressive disorder and neuropathic pain