SESIÓN 17 MYCOBACTERIUM TUBERCULOSIS. Flashcards
SESIÓN 17 MYCOBACTERIUM TUBERCULOSIS. OBJETIVOS: •Mencionará la clasificación de las especies de importancia médica. •Describirá las características fisiológicas y estructurales. •Describirá los factores de virulencia que intervienen en la patogenia e inmunidad •Mencionará los aspectos epidemiológicos. •Describirá los cuadros clínicos producidos por este microorganismo.
1
Q
What are 3 features that distinguished the Mycobacterium?
A
- 1) their acid-fastness
- 2) presence of mycolic acids
- 3) high guanine plus cytosine (G+C) content in their DNA.
2
Q
How can M. tuberculosis establish lifelong infection?
A
- Unlike most phagocytized bacteria, it prevents fusion of the phagosome w/ lysosomes by blocking the specific bridging molecule, early endosomal autoantigen 1 [EEA1]
3
Q
What do the macrophages secrete in response to infections with M. tuberculosis?
A
- They secrete Interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-A)
4
Q
What are some distinguishing features of M. tuberculosis?
A
- Produces niacin
- Produces heat-sensitive catalase (positive at body temperature)
