Session 8 - Drugs and Receptors Flashcards Preview

Semester 2 - Membranes and Receptors > Session 8 - Drugs and Receptors > Flashcards

Flashcards in Session 8 - Drugs and Receptors Deck (16):
1

How do drugs exert effects in the body?

By binding to target receptors

2

Name the three biggest targets for drugs

Enzymes
GPCRs
Ion channels

3

What are agonists?

Substances which mimick the actions of endogenous ligands and cause a response. Has both affinity and intrinsic efficacy.

4

What are anatgonists?

Substances which block endogenous ligands. Has affinity but NO intrinsic efficacy.

5

What is the concentration of drug molecules around receptors critical for?

The determination of drug action

6

What does MWt x Molarity equal?

g/L (mass)

7

What does g/L / MWt equal?

Molarity

8

What does g/l / M equal?

MWt

9

Why is it important to consider molarity?

Because drug molecules can be very different sizes, and so same mass can have vastly disproportional affects.

10

What is one of the most important factors in determining drug action?

The concentration of drug molecules around receptors is critical in determining drug action

11

Do drugs at equal molarity have proportional quantaties of drug molecules?

YES THEY DO SILLY

12

What is binding governed by?

By association and dissociation rates

13

What is the law of mass action related to?

It is related to the concentration of reactants and products.

14

How do we measure drug receptor interactions by binding?

By binding radioactively labelled ligands to cells OR membrans prepared from cells.

15

How many receptors is a large amount on a cell?

10,000 - 100,000

16

Page 37, page 4

j