Session Sixteen (Dissociative and Functional Disorders) Flashcards

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1
Q

What is a Functional Disorder?

A

A functional neurological disorder (FND) is a condition in which patients experience neurological symptoms such as weakness, movement disorders, sensory symptoms and blackouts. The brain of a patient with functional neurological symptom disorder is structurally normal, but functions incorrectly.

Poorly understood, most patients require years of treatment before diagnosis

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2
Q

What is a Dissociative Disorder?

A

Dissociative disorders (DD) are conditions that involve disruptions or breakdowns of memory, awareness, identity, or perception. People with dissociative disorders use dissociation as a defense mechanism, pathologically and involuntarily.

Possibly the conversion of affect or stress into physical symptoms

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3
Q

What are some other names given to F&D disorders?

A

Commonly called Catatonia or Resignation Syndrome

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4
Q

How are dissociative disorders classified in DSM-5?

A
  • Have their own category which includes; Dissociative Identity Disorder, Dissociative Amnesia, Depersonalisation disorder etc…
  • However tricky to classify as significant overlap with the Trauma/Stress Disorders as well as the Somatic disorders
  • Shares some notable elements with PTSD, Somatisation disorder, Acute stress disorder etc…
  • Some have suggested dissociation is less a symptom and more a common mechanism between a number of disorders (inc. PTSD, DD…)
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5
Q

Explain the terms primary and secondary gain in the context of F/D Disorders?

A

Primary gain = A decrease in anxiety from an unconscious operation which causes a physical symptom e.g. a person once used an arm to hurt someone, therefore that arm becomes functionally paralysed

Secondary gain = Gain achieved from the symptoms, which enables the patient to get support or avoid an activity, somehow to their benefit.

Malingering = Intentional production of false or exaggerated physical or psychological symptoms motivated by external incentives (secondary gain) e.g. avoiding military service or receiving medications

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6
Q

What is Dissociative Identity Disorder?

A
  • AKA Multiple Personality Disorder
  • Complex, chronic, post-traumatic, dissociative psychopathology
  • Characterised by disturbances in identity and memory
  • Controversial diagnosis, much disagreement as to how real it is.
  • Requires ongoing coexistence of relatively consistent yet alternating separate identities AND recurrent episodes of memory disruption
  • Basically needs to be Dr Jeckyl and Mr Hyde for diagnosis to apply, which is unlikely
  • However cases that are confirmed almost certainly related to overwhelming childhood experiences
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7
Q

What is Dissociative Amnesia?

A
  • Inability to access memories
  • That isn’t explained by normal memory issues, dementia.
  • Stress or trauma induced
  • Specific focus on important personal information
  • If paired with purposeful travel or bewildered wandering its called a “fugue state”.
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8
Q

What is Depersonalisation/Derealisation disorder?

A
  • Condition marked by a state of unreality and detachment
  • Patients describe using phrases such as “it’s as if…”
  • Often triggered by adverse life events, severe anxiety, cannabis use
  • Often state is secondary to an underlying psych diagnosis
  • Can be a Primary disorder, although rarer

“I feel as if I’m living in a dream”, “I feel like I don’t exist anymore”, “it’s like I’m watching life behind glass”

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9
Q

What are MUS?

A

Physical symptoms disproportionate to pathology.

Medically unexplainable, could potentially be explained:

  • Psychologically
  • Sociologically
  • Behaviourally
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10
Q

How can MUS be sub-divided?

A

1) The genuinely unexplainable

2) Functional, psycho-somatic, non-organic conditions
- Multi system (somatisation)
- Single system (CF, IBS, FND…)

3) Simulated
- Malingering
- Facticious

Overall, 50% of primary care appointments, however psychiatry only cares about number 2, which actually makes up a very small proportion of people.

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11
Q

What are the different forms of simulated/feigned illnesses?

A

Malingering = feigning illness for external motivation e.g. money. Not a psych diagnosis.

Munchausen’s syndrome = a factitious disorder, a mental disorder in which a person repeatedly and deliberately acts as if he or she has a physical or mental illness when he or she is not really sick. Munchausen syndrome is considered a mental illness because it is associated with severe emotional difficulties

Factitious syndrome = Factitious disorder is a mental disorder in which a person acts as if he or she has a physical or mental illness when, in fact, he or she has consciously created the symptoms. These people are willing to undergo painful or risky tests to get sympathy and special attention

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12
Q

What is the difference between Munchausen and Factitious disorder?

A

In Munchausen the patient believes they have a disease, is deeply convinced they are ill when they aren’t.

FD is similar but the patient also takes the step of creating the symptoms themselves

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13
Q

What is Hypochondriasis?

A
  • Persistent preoccupation with having one specific illness
  • Obsessional, anxious, perfectionist personality traits are super common
  • Marked by catastrophic thinking
  • Normal sensations become amplified
  • CBT normally effective
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14
Q

What is Somatic Symptom Disorder?

A
  • AKA Briquet’s
  • Physical symptoms that suggest illness or injury, cannot be explained through a medical condition
  • Must be excessively worried about their condition
  • Requires somatic complaints for at least six months
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15
Q

Give some examples of Functional Somatic Syndromes (symptoms experienced by those with a Somatic Symptom Disorder)

A
  • Seizures
  • IBS
  • Atypical chest pain
  • Fibro
  • PMS
  • CFS
  • Lyme
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16
Q

How have some people attempted to explain Somatic Symptom Disorders such as Chronic Lyme disease?

A

Actually a form of FND (hiding in plain sight).

Often wrongly considered a rare medical curiosity, commonly seen in the news.

17
Q

What is a Functional Neurological Disorder?

A
  • Neuro symptoms
  • Not explainable by a neurological disorder
  • Sometimes known as conversion disorder
18
Q

How does FND compare to other neuro disorders in terms of prevalence or disability?

A
  • 12% of neuro OP clinics
  • As common as MS or Parkinson’s
  • Can cause similar levels of functional disability
19
Q

Who normally gets FND?

A

Young adults, 2-3 times more common in women.

20
Q

What history do individuals with FND normally report?

A
  • Trauma history is common
  • Often onset of FND is preceded by physical injury or disease

Numerous common co-morbidities:

  • Epilepsy
  • Dissociative seizures
  • Stroke
  • MS
21
Q

What signs can be elicited in a person with FND to show they have the condition rather than a physiologically explainable one?

A

Test for conscious vs unconscious differences:

  • If their observed strength (e.g. can open a heavy door) is greater than on observation
  • Hoover’s sign: feel ‘paralysed’ leg and ask them to lift other leg, check for compensatory muscle tension. Shows theoretically leg is functioning
  • Inconsistency in symptoms
  • Tremor that can be gotten rid of e.g. by asking them to tap their feet

Can also test for symptoms at different with anatomy:

  • e.g. sensory deficit in an area that doesn’t make sense
  • Tubular visual field defect
  • Collapsing weakness (strong initially but suddenly collapse)
22
Q

What are Dissociative Seizures/PNES and how common are they?

A

Psychogenic nonepileptic seizures are paroxysmal episodes that resemble and are often misdiagnosed as epileptic seizures; however, PNES are psychological (i.e., emotional, stress-related) in origin. Paroxysmal nonepileptic episodes can be either organic or psychogenic

Represent 5-25% of patients referred to outpatient epilepsy centres.

N.B. About a third of PNES patients also have real epilepsy.

23
Q

How can you distinguish Epilepsy from PNES?

A

Age of onset: Rare for PNES to onset below 10, epilepsy commonly does.

Features common in PNES but rare in epilepsy include:

  • Occuring in presence of doctors
  • Recurrent nature
  • Multiple unexplained physical symptoms
  • Psych treatment
  • History of sexual or physical abuse
  • History of neglect

Can also be distinguished based on seizure appearance:

  • PNES = Eyes closed, Head moving side to side, Body arching, Intense body rotation, Interupted or fluctuating course
  • Epilepsy = Eyes open, Head fixed, Body straight, No rotation, Continuous course
24
Q

What is dissociation according to DSM-5?

A

Disruption of and/or discontinuity in the normal integration of consciousness, memory, identity, emotion, perception, body representation, motor control, or behaviour.

Possibly the separation of awareness from other brain functions

Can potentially disrupt every area of psychological and neurological functioning

25
Q

What is Conversion Disorder?

A
  • Conversion disorder is a mental condition in which a person has blindness, paralysis, or other nervous system (neurologic) symptoms that cannot be explained by medical evaluation
  • A form of FND, but crucially is much more associated with stressful live events (56% of patients have severe life events, 53% have escape events). 1/3rd of female patients could directly trace symptom onset to sexual abuse.
  • Also report higher neglect, physical abuse, emotional abuse…
  • Conversion of emotional stress into a physical disease.

HOWEVER many patients do not report any form of stress. Important but not diagnostic.

26
Q

How has neuropsychiatry attempted to explain functional disorder?

A

Complex, genesis is likely highly multi-factorial and involving:

  • Psychosocial adversity
  • Biological vulnerability
  • Altered emotional processing
  • Affective hyper-arousal
  • Heightened responsibility
  • Impaired awareness of sensory and motor processes
  • Impaired control over these processes
  • Automatic activation of these processes
27
Q

What brain regions have been implicated in Functional Disorder?

A
  • Enhanced preconscious processing of emotionally salient stimuli due to elevated limbic reactivity
  • Affect-related brain regions may exert a disruptive influence on neuro-circuits involved in motor control
  • Prolonged or early psych adversity may lead to limbic and para-limbic disturbances
28
Q

Outline the Bayesian /Attentional model of Functional Disorders?

A
  • The relationship between sensory evidence of the world around us and our prior, existing beliefs is mediated by a number of factors (attention, physical and emotional experiences, beliefs about illness, expectations of illness)
  • This model suggests that early life experience create abnormally strong top-down predictions (termed priors) which are able to overwhelm any contradictory bottom-up sensory evidence
  • Essentially, we interpret sensations and symptoms based on “priors” (expectations etc we have) and actual sensory info, in FD trauma causes overly strong priors to overwhelm sensory info and create symptoms when they aren’t being reported by our sensory apparatus.
  • Highly speculative, but interesting
29
Q

What is prognosis like for FND?

A

Pretty bad.

  • Stone et al: After a 7 year follow up, 39% of patients either showed no improvement or worsening
  • Carson et al: 50+% of patients who’d seen a neurologist for MUS showed 0 improvement after 8 months
30
Q

What are the basic steps to managing Functional Disorders?

A

Focus on:

  • Accepting symptoms
  • Offering rationale
  • Use positive signs positively
  • Discourage further investigations
  • Encourage recovery
31
Q

What is the best treatment for Dissociative Identity Disorder?

A

Long term, one-to-one psychotherapy

32
Q

What is the best treatment for Dissociative amnesia?

A

CBT or DBT, sometimes combined with hypnosis or drug-facilitated interviews

33
Q

What is the best treatment for Depersonalisation/ derealisation?

A

Treat underlying cause, offer psych therapy

34
Q

What is the best treatment for Hypochondriasis?

A

CBT

35
Q

What treatment has been shown to be highly effective for Functional Movement Disorders?

A

Physiotherapy, essentially treating them as you would a patient with Medically Explainable Symptoms.

36
Q

What treatment plan for PNES has been supported by research evidence?

A

CBT-ip + Sertraline.

Lead to a 60% reduction in seizures.

37
Q

What new treatments may be effective in the management of FNDs

A
  • Sedation
  • Trans-cranial magnetic stimulation
  • Antidepressants
  • Psychedelics