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Sexual health Flashcards

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1
Q

What are genital warts?

A
  • condylomata acuminata
  • lesions usually affecting the introitus and vulva but can occur on cervix, anus,
  • caused by HPV 6 and 11 most commonly
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2
Q

How are genital warts transmitted?

A
  • sexual activity

- autoinocculation

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2
Q

How are genital warts transmitted?

A
  • sexual activity

- autoinnoculation

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3
Q

List 4 differential diagnoses of genital warts

A
  • molluscum contagiosum
  • sebaceous cysts
  • condolymata lata of secondary syphilis
  • tumours
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4
Q

List 3 types of management options for genital warts

A
  • conservative
  • medical
  • surgical
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5
Q

What are the conservative management options for warts?

A
  • let immune system recognise and clear itself
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6
Q

What are the medical management options for genital warts?

A

Imiquimod - immune modulator

podophyllotoxin - cytotoxic agent

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7
Q

What regimen of podophyllotoxin would you recommend?

A

Clinician applied or patient applied
Clinician applied regimen twice weekly
patient applied regiment twice daily

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8
Q

What regimen of imiquimod would you recommend for genital wart treatment?

A

5% once daily

3x weekly for 10 hours at a time fo 16 weeks if hasn’t responded to podophyllotoxin

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9
Q

What are the surgical management options for treatment of genital warts?

A

excisional
diathermy or cold knife used
clearance of 90-100%
recurrence 20-30%

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10
Q

What is the clearance rate using imiquimod for genital wart treatment?

A

40-70%

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11
Q

What is the risk of recurrence of genital warts following treatment with imiquimod?

A

1/4 recur

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12
Q

What is the clearance rate of genital warts treated with podophyllotoxin?

A

45-80%

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13
Q

What is the risk of recurrence following treatment with podophyllotoxin for genital warts?

A

15-100%

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14
Q

How can genital warts be treated in pregnancy?

A

Best treatment is cryotherapy or electrocautery

Avoid cytotoxic medications - podophyllotoxin + imiquimod

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15
Q

A pregnant woman wants to know the risks of genital warts during pregnancy what would you advise her?

A

vertical transmission is rare but can occur
It causes laryngeal papillomas which can develop as late as 12 years after exposure
genital warts are not an indication for CS unless they are obstructive

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16
Q

What is molluscum contagious?

A

a common, contagious infection caused by the pox virus

presents with multiple small lesions that are pearly white in colour and have a small dimple in the middleH

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17
Q

How are molluscum contaigiosum treated?

A

self limiting - will resolve in several months

cryotherapy or electrocautery

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18
Q

How could you categorise genital ulcerative lesions?

A

infectious - sexually transmitted and non sexually transmitted
non infectious - BAMI - blistering, aphthous, malignant and inflammatory

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19
Q

List 6 causes of infectious sexually transmitted ulcerative genital lesions

A
  • HSV 1 and 2
  • syphilis
  • gonorrhoea/trichomonas vaginitis
  • lymphogranluma vereneum (chlamydia trichomatis)
  • chancroid (haemophilia ducreyii)
  • donavanosis (klebsiella granulomatosis)
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20
Q

List 7 causes of infectious but non sexually transmitted genital ulcers

A
  • severe candidiasis
  • herpes zoster affecting lumbar or sacral roots
  • TB
  • CMV
  • EBV
  • Mycoplasma
  • group A strep
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21
Q

list 4 possible causes of aphthous genital ulcers

A
  • Chrons
  • SLE
  • HIV
  • Post infection e.g. EBV
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22
Q

List 5 causes of inflammatory ulcers (non STI)

A
  • dermatitis
  • lichen planus
  • lichen sclerosis
  • fixed drug eruption
  • Steven johnson syndrome
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23
Q

List 3 causes of blistering ulcers

A

pemphigus vulgaris
bullous pemphigoid
erythema multiforme

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24
List 3 causes of malignant ulcers
vulval SCC VIN BCC
25
What investigations would you undertake to review a genital ulcer
- swab for HSV 1 and 2 - NAAT for chlamydia and gonorrhoea - bacterial swab for gram staining - blood for syphilis/HIV serology - consider bloods for; HSV, EBV, CMV, mycoplasma, FBC, CRP, ANA - consider biopsy if diagnosis cannot be made otherwise
26
What are the general management principles for genital ulcers?
- minimise irritants - sitz bath - cool compress - topical anaesthetic - oral analgesia
27
What is the treatment for Lymphogranuloma venereum?
oral doxycyclineW
28
What is the treatment for chancroid (haemophilia ducreyii)
ceftriaxone/azithromycin/ciprofloxacin or erythromycin
29
How are HSV1 and HSV2 transmitted?
HSV 1 - oral to genital | HSV 2 - genital to genital
30
What are the symptoms of primary HSV infection?
``` fever, myalgia dysuria vaginal discharge painful ulceration lymphadenopathy ```
31
What are the symptoms of secondary HSV infection?
asymptomatic ulcers - usually less painful than primary prodromal symptoms such as tingling
32
How do you investigate for HSV?
- swab base of HSV lesion with viral PCR swab - HSV serology only recommended in suspected primary episode in pregnancy - syphilis serology recommended
33
How would you counsel a patient who has just been diagnosed with HSV and is upset at diagnosis?
- very common 1:3-5 people affected - only 20% of people have symptoms - shedding occurs even when not symptomatic - does not affect long term health, fertility, cancer risk
34
What are the management principles for HSV infection?
Primary infection - valaciclovir 500mg PO BD 7 days Sitz bath, passing urine in bath, loose clothing, cool compress oral analgesia IDC if retention local anaesthetic topically Fully sexual health screen
35
What are the management principles for secondary infection?
avoid triggers avoid tampon use while menstruating COCP continuously to suppress menstruation episodic treatment - valaciclovir 500mg BD for 3/7 suppressive treatment - valaciclovir 500mg daily for 1 year then break for 3 months
36
What causes syphilis
infection with bacteria treponema pallidum gram -ve spirochete spread by close contact and sexual contact separated into primary, secondary, tertiary and latent
37
What is the pattern on syphilis serology re; progress
IgM --> IgG --> TPPA ---> VDRL
38
what is the normal vaginal pH
3.8-4.5
39
List 6 factors that can impact on vaginal discharge
``` menses intercourse douching intravaginal preparations (medications) contraception antibiotics pregnancy ```
40
List your female screening tests for STI (if symptomatic)
- Speculum exam - HVS + endocervical NAAT for chlamydia, trich, gonorrhoea - anorectal swab - chlamydia and gonorrhoea - throat swab - gonorrhoea - serology - syphilis, HIV, Hep B
41
Should asymptomatic people get screened for mycoplasma genitalium?
No - no evidence as to what the clinical implications are for asymptomatic MG
42
What are the common causative microbes associated with PID
``` E. Coli Chlamydia gonorrhoea BV vaginal anaerobes streptococci mycoplasma genitalium ```
43
what percentage of PID has no known causative agent
70%
44
What is the recommended antibiotic regimen for PID?
ceftriaxone 500mg in 2mL of 1% lignocaine IMI +/- 1g azithromycin STAT orally metronidazole 400mg PO BD for 14 days doxycycline 100mg BD for 14 days *if breast feeding replace doxy with 2nd dose of azithromycin day 7
45
What extra precautions would you give to someone who has been diagnosed with PID
no sex for 1/52 following treatment simple analgesia follow up in 2-3 days an IUD may be kept in situ if symptoms improve NB - most PID is sexually transmitted but most swabs are negative therefore still recommend partner treatment with STAT azithromycin and contact tracing
46
what is the incidence of chlamydia?
47
what is the reinfection rate of chlamydia?
22% | 28% occur in 3/12 following diagnosis
48
when should chlamydia testing be repeated?
3/12 after first test
49
what is the best treatment for rectal chlamydia
doxycycline
50
what are the impacts of chlamydia on pregnancy?
- increased risk of PTB | - increased rate of post partum fever
51
what are the risks of chlamydia on a neonate?
conjunctivitis 50% | pneumonia 30%
52
what is the treatment for chlamydia
1g PO azithromycin STAT | - 100mg BD 7/7 of doxy if anorectal infection
53
what percentage of gonorrhoea infections cases are asymptomatic for women?
50%
54
list 3 high risk groups for gonrrhoea
- MSM - aboriginal - recent overseas travel
55
what is the treatment for gonorrhoea
1g azithromycin | 500mg IM ceftriaxone
56
what are the impacts of gonorrhoea infection on pregnancy?
- PTB rate increases | - post partum fever rate increases
57
what is the effect of gonorrhoea on neonates?
conjunctivitis - blindness 5% | disseminated infection 1%
58
what is Amsel's criteria?
- used to diagnose BV - 3 of 4 findings to make diagnosis: - offensive vaginal discharge - vaginal pH >4.5 (alkaline) - positive amine test with KOH - clue cells on microscopy of wet film
59
List 3 possible treatment options for recurrent BV
• Attempts with colonisation with exogenous L. crispatus – can be helpful in some women but causes worsened symptoms in others • Suppressive treatment : metronidazole gel twice weekly for 16 weeks after initial 10 days of treatment 26% vs 60% recurrence Sobel 2006 Am J Obstet Gynae • Suppressive clindamycin cream → can lead to secondary fungal infections

Gynaecology (25 decks)

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