Sexually transmitted infections & GI tract Flashcards

(37 cards)

1
Q

what is sex?

A

= contact between the penis and the vulva or the penis and the anus involving penetration, however slight; contact between the mouth and penis, vulva, or anus; or penetration of the anal or genital opening of another person by a hand, finger, or other object.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how are infections transmitted during sex?

A
  • sexual/genital secretions
  • direct inoculation, skin on skin e.g. Herpes
  • trauma, e.g. Hepatitis C virus
  • IVDU = injection drug user e.g. HIV, HCV
  • fomites = an innate object e.g. gonorrhoea
  • ingestion, e.g. shigella, campylobacter
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

True or false.

Anal sex is a pre-requisite for a rectal STI?

A

= FALSE

anal sex is NOT a pre-requisite for a rectal STI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how can rectal STIs arise?

A
  • Passive transfer of vaginal secretions (chlamydia, gonorrhoea)
  • Oro-anal contact/“rimming” (gonorrhoea, herpes)
  • On sex toys or fingers (gonorrhoea, chlamydia)
  • Systemic/haematogenous spread (syphilis)
  • Local spread (herpes, warts)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are risk factors for STIs?

A
  • <25year olds
  • changing sexual partner
  • no Condom use
  • men who have sex with men (MSM)
  • past history/contact of STI
  • large urban areas
  • social deprivation
  • black ethnicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

where can STIs present?

A

= anywhere in GI tract from mouth to anus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is procto-colitis?

A

inflammation of rectum and colon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

how would you advice someone with a STI?

A
  • not to have sex until end of antibiotics
  • inform other people that need to know
  • safe sex advice
  • substance use
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what causes rectal gonorrhoea?

A

= neisseria gonorrhoea

gram negative cocci

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how is gonorrhoea transmitted?

A

= direct contact of mucosal surfaces with infected secretions

  • for proctitis; anal sex, transmucosal spread, fomit
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are symptoms of gonorrhoea?

A
  • short incubation period (5-10days)
  • lower abdominal pain, diarrhoea, rectal bleeding, anal discharge, tenesmus
  • associated symptoms (urethral/vaginal discharge, dysuria)
  • may be asymptomatic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what investigation would you do for gonorrhoea?

A

= protocscopy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what would you find on a protocscopy of gonorrhoea?

A

= inflamed mucosae

= purulent exudate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are complications of gonorrhoea?

A
  • abscess formation

- increased susceptibility/transmissibility of HIV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what causes the spread of rectal chlamydia?

A

= chlamydia trachomatis (serovars D-K)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how is rectal chlamydia transmitted?

A

= same as gonorrhoea

= direct contact of mucosal surfaces with infected secretions

  • for proctitis; anal sex, transmucosal spread, fomit
17
Q

what percentage of chlamydia in male sex with men is solely found in rectum?

18
Q

what are symptoms of chlamydia?

A
  • 70% asymptomatic
  • milder than gonorrhoea
  • anal discomfort/itch, discharge
  • associated symptoms
19
Q

what would you find on a proctoscopy of rectal chlamydia?

A

= less severe

20
Q

how would you diagnose chlyamdia?

A

= gram stain rectal swab

  • CT (and GC)
  • PCR (all sites)
21
Q

how would you treat rectal chlamydia?

A

= doxycycline (7/7day course)

  • better clearance at rectal sites
  • test cure
  • comprehensive STI testing
  • public health intervention
22
Q

Yes or no.

Can you culture chlamydia?

A

= no

- but you can culture gonorrhoea

23
Q

in summary, what diagnosis/testing would you do fo chlamydia and gonorrhoea?

A
  • gram stain of discharges
  • chlamydia and gonorrhoea PCR
  • gonorrhoea cultures
  • STI testing of all sexual sites
24
Q

what is lymphogranuloma venereum associated with?

25
who often gets lymphogranuloma venereum?
- male sex with men | - often HIV
26
what is lymphogranuloma venereum associated with?
- group sex - drug use - syphilis - hepatitis C
27
describe the clinical features of lymphogranuloma venereum?
Primary (3-30days) - ulcer Secondary (3-6/12) - inguinal syndrome - ano-rectal syndrome Tertiary - strictures - fistulae - genital elephantiasis
28
who should you test for, for LGV?
- MSM with haemorrhagic proctitis - HIV+ MSM with positive rectal chlamydia - Suspicious ulcers in MSM - Failed chlamydia test of cure - Contact of LGV Anyone diagnosed with LGV should be tested for HIV, hepatitis C, syphilis....
29
describe the two types of syphilis?
Primary syphilis - solitary painless ulcers Secondary syphilis - mucosal patches & ulcers - mouth, anogenital, rectal - condylomata lata (wart like lesions on genitelia) - systemic inflammation - hepatitis - procto-colitis
30
how is herpes simplex virus transmitted?
= ano-genital or oro-anal = usually HSV 2 (in HSV proctitis) = usually per-anal mucosa but may extend into rectum
31
what are symptoms of herpes simplex virus?
- PAIN - ulcers - painful defaecation - bleeding - mucus - viraemic symptoms (in primary infections)
32
how is the human papllomavirus transmitted?
= ano-genital, oro-anal | wart virus
33
describe the types of HPV?
- HPV 6, 11, 16, 18
34
what does the human papilloma virus usually cause?
= anal warts - can extend to the rectum - increasing prevalence of AIN and anal cancers (MSM and HIV+ people) - HPV vaccination for MSM available
35
what is the largest immune compartment in the body?
= gut associated lymphoid tissue (GALT)
36
what is the gut therefore, highly susceptible to?
= HIV infections
37
what are some clinical consequences of loss of gut associated lymphoid tissue?
- unknown - HIV enteropathies - opportunistic infection (e.g. cryptosporidiosis) - persistent immune activation = microbial translocation - accelerated immune-senescence