sft Lung Cytology Flashcards

(36 cards)

1
Q

Saccomanno Method

A

for sputum cytology; 50% ethanol, 2% carbowax, spun at slow rate to homogenize specimen, then smeared

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2
Q

BAL adequacy criterion

A

at least 1 pulmonary macrophage

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3
Q

What is this; what is it associated with?

A

Creola body (benign cells with cilia on edge); Asthma

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4
Q

Differential, more specific finding, etiology?

A

Pulmonary alveolar proteinosis (must rule out necrosis and Pneumocystis); in Pap stain, dense globules are more specific than granular debris; usually autoimmune.

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5
Q

Diagnosis? Buzz words? Risk factors?

A

PJP, alveolar casts of fluffy debris, crushed ping pong balls on GMS

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6
Q

Fungus type? Clues?

A

Uniform thickness, septations, acute angle branching

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7
Q

Fungus type? Clues?

A

Cryptococcus, plemorphic yeast forms, thick capsule highlighted by mucicarmine

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8
Q

Fungus type? Clues?

A

Zygomyces/Mucor; variable hyphal thickness, no septations, right angle branching

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9
Q

Organism?

A

Coccidioides; large spherule with endospores

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10
Q
A

Strongyloides stercoralis

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11
Q
A

Paragonimus westermani, thick shell with shouldered operculum

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12
Q

Name of CMV inclusion?

A

Cowdry type A body

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13
Q
A

Necrotizing granuloma (left) with giant cells (right), as in Mycobacterium tuberculosis infection.

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14
Q
A

Necrotic debris with filamentous Nocardia organisms

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15
Q

How do non-tuberculoid mycobacterial infections present?

A

MAC, usually present as aggregates of histiocytes filled with organisms

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16
Q

Differential? Name of the thing with the arrow.

A

Non-necrotizing granuloma, like in sarcoid. Arrow points to an asteroid body with a giant cell (common in sarcoid but not specific)

17
Q
A

Asbestos/ferruginous bodies (stain + for iron)

18
Q
A

Plant matter on left (refractile cell wall); skeletal muscle on right (aspirated meat)

19
Q

Specific name of finding? Association?

A

Curschmann spiral; inpissated mucus seen in asthma patients

20
Q

Finding?

A

Collagen balls, commonly seen in pleural effusions; Thin rim of streaming nuclei around periphery

21
Q

Finding? Cause?

A

Cornflaking, caused by air trapping during coverslipping

22
Q
A

Pollen, round, refractile borders, no internal structure

23
Q
A

Alternaria . Air-borne contaminant fungi that have short yellow-brown conidiospores with transversely and longitudinally septate macroconidia (snow shoe-like/hand-grenade)

24
Q
A

Starch granules

25
Diagnostic finding?
Lung adenocarcinoma, intracytoplasmic mucin
26
In lung, diagnosis?
Micropapillary carcinoma
27
In lung, dx?
SCC (keratinization in pap stain and diff quick, left and right, respectively)
28
Lung, dx? Features?
Small cell carcinoma, nuclei 2-3x background lymphs, salt and pepper chromatin, frequent mitoses, necrotic diathesis, molding/crush artifact, indistinct nucleoli
29
Lung, dx? How to differentiate from similar appearing cells?
Carcinoid tumor; plasmacytoid cells in rosettes with neuroendocrine nuclei; lack mitosis and necrotic background
30
When to consider mesothelioma on cytology?
Marked mesothelial nuclear atypia or clusters \>15 cells.
31
Pleural effusion fluid, dx?
Benign papillary mesothelial proliferation with psammoma bodies.
32
What are the 3 patterns of mesothelioma?
epithelial, sarcomatoid, mixed/biphasic
33
IHC for mesothelial vs carcinoma
Ours is WT1, calretinin, MOC31, BEREP4; mesothelial also + for D240 and CK5/6, HMBE-1; carcinoma also + for mCEA, TTF1 if lung or thyroid
34
Pleural effusion, dx?
Mesothelioma (incredibly large clusters are almost always malignant)
35
Most common causes of malignant effusions?
36
Primary effusion lymphoma. IHC and associations?
HHV8 (often EBV coinfected); associated with Kaposi sarcoma and multicentric Castleman disease (+/- plasmablastic lymphoma)