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HHD 2 and Pharma > Shock > Flashcards

Shock Flashcards

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1
Q

What the 6 types of shock

A

Types of shock : SHOCAN
1. Hypovolaemic
2. Septic
3. Obstructive
4. Neurogenic
5. Cardiogenic
6. Anaphylactic

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2
Q

What is the definition of Shock

A

“Acute circulatory failure, with inadequate tissue perfusion causing cellular hypoxia”

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3
Q

Will pt with shock always have abnormal blood pressure

A

No - can have normal BP

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4
Q

Clinical features vary dependant on ….
Is “Hypotension” and “shock” interchangeable

A

Clinical features vary dependant on the mechanism
- “Hypotension” and “shock” are NOT interchangeable

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5
Q

What are pre and after-load?

A

Pre-load: before the heart
After-load : after the heart

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6
Q

AETIOLOGY:
Which types of shock are pre-load and give examples

A

Hypovolaemia:
- Haemorrhage
- Fluid loss
- Dehydration

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7
Q

Which types of shock involve the heart and give examples

A

Cardiogenic:
- MI
- CCF
- Arrhythmia

Obstructive - prevent the contraction
- PE
- Tamponade
- Pneumothorax

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8
Q

Which types of shock are after-load and give examples

A

Vasodilatory: prevents blood (or leaking) from reaching tissues and organs
- Sepsis
- Neurogenic
- Anaphylactic
- Adrenal insufficiency - this is y SNS is impor.

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9
Q

PATHOPHYSIOLOGY:
What are the initial steps in the shock cascade

A

*Circulatory failure leads to hypoperfusion which causes hypoxia

*Cells switch to anaerobic energy production –> lactic acidosis

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10
Q

PATHOPHYSIOLOGY:
What are the compensatory steps in the shock cascade?

A
  • Body attempts to rectify hypoxia and lactic acidosis by:
    –> * hyperventilation - to raise pH
    —> *release of adrenaline and noradrenaline from adrenals - to increase pressure
    —> *renin-angiotensin system activation (RAAS) - stimulates a rise in BP and so kidneys increases water retention
  • Blood diverted to essential organs (heart, brain, lungs) and away from the skin, GI tract
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11
Q

PATHOPHYSIOLOGY:
What are the progressive steps in the shock cascade?

A

*Compensatory mechanisms begin to fail.

  • Decreased perfusion of the cells leads to Na+/K+ pump failure
    –> Intracellular sodium increases and potassium leaks out - cells can’t function
  • Leakage of water/protein into surrounding tissues –> Blood viscosity increases
  • Essential organs now compromised due to reduced perfusion
  • If the gut is compromised, bacteria may enter the bloodstream, resulting in the release of endotoxins - usually gram- negative bacteria
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12
Q

PATHOPHYSIOLOGY:
What happens in the refractory step of the shock cascade?

A

*Essential organs fail
–> brain damage
–> multiorgan failure
–> death

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13
Q

Which step in the shock cascade must medicine be successful when treating shock

A

must be successful during the compensatory step to prevent progression to multi-organ failure

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14
Q

Which are the 5 clinical features of shock can we can observe?

A

Observations of shock:
1. Tachypnoea
2. Tachycardia
3. Hypotension
4. Hyper or hypothermia
5. Poor urine output - good indicator to increase fluid intake

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15
Q

What are the 7 clinical SIGNS OF DECREASED TISSUE PERFUSION in pt with shock?

A
  1. Cool peripheries
  2. Poor filling of peripheral veins
  3. Cool to the touch
  4. Warm to the touch —> sepsis/neurogenic shock
  5. Metabolic acidosis
  6. Elevated lactate
  7. Restlessness or decreased conscious level
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16
Q

what are the 3 steps in the GENERAL APPROACH TO SHOCK

A
  1. Resuscitate
  2. Diagnose
  3. Treat underlying cause
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17
Q

What are the general principles used to manage sick patient

A

ABCDE principle
A = Airway and oxygenation
B= Breathing and ventilation
C = Circulation and shock management
D = Disability due to neurological deterioration
E = Exposure and examination

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18
Q

What is common cause of shock

A

HYPOVOLAEMIC SHOCK

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19
Q

What is Hypovolaemic shock?

A

Low cardiac output direct reflection of reduced venous return (preload) - low blood volume so the cardiac output is low

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20
Q

How do we measure Hypovolemic shock

A

By measuring the cardiac out
CO = SV x HR

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21
Q

How do we measure Hypovolemic shock

A

By measuring the cardiac out
CO = SV x HR

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22
Q

What are the 4 causes of hypovolemic shock?

A
  1. Haemorrhage
  2. Loss of GI fluid
  3. Burns
  4. Renal loss - the distal tubule and collecting duct
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23
Q

HYPOVOLAEMIC SHOCK - HAEMORRHAGE:
What are the 4 ways of losing blood via haemorrhages other than visual blood loss

Study These Flashcards
A

‘Blood on the floor and four more”
1. Intrathoracic
2. Retroperitoneal - beyond the abdomen - kidney and aorta
3. Pelvis
4. Intrabdominal

24
Q

What are the 4 HYPOVOLAEMIC SHOCK - HAEMORRHAGE classifications and what are the percentages of blood loss in each class?

Study These Flashcards
A

Classification of shock:
I). 15% (<500ml blood loss)
II). 15-30% (500-1000ml blood loss)
III). 30-40% (1000-2000ml blood loss)
IV). >40% (>2000ml blood loss) - reversibility is uncertain

25
HAEMORRHAGE MANAGEMENT: What are the 3 HAEMORRHAGE MANAGEMENTs
1. Advanced Trauma Life Support (ATLS) algorithm if the history of trauma - most of western world deals with trauma 2. Trauma CT “the afghanogram" 3. Baseline (and multiple repeat) lactate, pH and haemoglobin levels
26
What are the 5 principles of haemorrhage management?
Principles of haemorrhage management: 1. ID the source of the haemorrhage - pelvis, brain blood on the floor and 4 more 2. Stop haemorrhage (pressure, tourniquet, surgical intervention) 3. Replace blood products (1:1:1 resuscitation) 4. Tranexamic acid - prevent clotting 5. Avoid using lots of crystalloids (adds to haemodilution and have no clotting ability - have to balance)
27
HYPOVOLAEMIC SHOCK - LOSS OF GI FLUID : What are the 3 methods of losing GI fluid ?
1. Vomiting & diarrhoea 2. Fistulae - an abnormal connection between two body parts or an organ and the external body 3. Sequestration of fluid in bowel lumen due to obstruction - not in circulation
28
What is the DEHYDRATION MANAGEMENT:
Assess pt with the ABCDE approach
29
what are 5 DEHYDRATION MANAGEMENTs
- Baseline obs (HR, b/p, central capillary refill) - Gain IV access - Baseline bloods including lactate & electrolytes - Fluid challenge intake (crystalloid) - Monitor urine output hourly- aim for >0.5ml/kg/hr
30
What are the 3 main types of fluids used in dehydration management? and name a pro for each one.
ISOTONIC: - NaCl 0.9% Pro: Corrects ECF loss - Ringer's Lactate Pro: Generates Bicarbonate - reduces risks of hyperchloraemia and is a physiological - Dextrose 5% Pro: Glucose is rapidly metabolised
31
HYPOVOLAEMIC SHOCK - BURNS: What are the three degrees of burns and the extent of skin damage
1. Superfical - 1st degree only in the epidermis layer 2. Partial thickness - 2nd degree in the epidermis and dermis layers 3. Full-thickness - 3rd degree in the epidermis, dermis and the subcutaneous layer and almost in the muscle
32
HYPOVOLAEMIC SHOCK - BURNS: Burns management ?
ABCDE assessment of patient --> remember that airways swell rapidly in inhalation injury Assess the percentage of burns using Lund & Browder chart
33
What is the formula used for burns fluid resuscitation?
- Use Parkland formula for fluid resuscitation: 4ml x Burns Surface Area (%) x weight (kg) = total crystalloid volume - Give 1⁄2 of the volume in the first 8hrs - Give 1⁄2 of the volume in subsequent 16hrs
34
what is CARDIOGENIC SHOCK
Primary impairment of cardiac function may result from myocardial infarction/ischaemia, acute arrhythmias, acute cardiomyopathy, acute valvular lesions and myocardial contusion (blunt trauma to the chest)
35
What are the PRESENTATIONs of CARDIOGENIC SHOCK
- Chest pain, palpitations, syncope - fainting bcs of low BP No reduction in circulating volume leads to additional features: - Elevation of central jugular venous pressure - vein is bulky - Pulmonary oedema
36
What does an acute myocardial infraction cause
acute myocardial infarction results in a reduction in SV and CO and increased Left ventricular end-diastolic pressure LVEDP, Pulmonary edema and hypoxia These cause the release of inflammatory biomarkers and catecholamines which then causes Vasoconstriction --> increasing myocardial work and oxygen demand resulting in Cardiogenic shock!
37
What are the medicine steps used during an acute myocardial infarction to prevent it lead to shock
Inotropes, vasopressors and MCS: prevent HTN and the reduction of SV and CO Revascularisation: to prevent ischemia Oxygenation and mechanical ventilation: prevent increase in LVEDP, P.edema and Hypoxia
38
Which histories can cause Cardiogenic shock ?
History may indicate the cause of cardiogenic shock: - PMHx of angina, MI, HTN, hypercholesterolaemia, T2DM
39
Cardiogenic shock Management?
Assess pt using the ABCDE approach Baseline bloods (including troponin) ECG Avoid large volumes of IV fluidwill lead to overload May need ionotropic support Treat underlying cause
40
What is OBSTRUCTIVE SHOCK? Name 3 examples of Obstructive shock
Secondary impairment to cardiac function results from physical obstruction to cardiac output 1. Cardiac tamponade - space in the cardiac lining - myocardial cavity is filled with blood- heart is squashed so it cant expand 2. Tension pneumothorax - the heart is getting squashed 3. Major pulmonary embolism -blockage in the pulmonary artery
41
PRESENTATION OBSTRUCTIVE SHOCK
Tamponade and tension pneumothorax are usually associated with a history of thoracic trauma (usually penetrating but can happen in blunt mechanisms) *Remember the classical presentation of PE and risk factors
42
What are the 3 factors in the cardiac tamponade : Beak Triad
Beak triad - hypotension - jugular venous distension - Muffled heart sounds
43
Cardiac tamponade and tension pneumothorax share 2 presentations but what is the main difference?
both present with - hypotension - jugular venous distension but with tension pneumothorax there are absent breath sounds whilst cardiac tamponade has muffled heart sounds
44
What is NEUROGENIC SHOCK What happens during neurogenic shock ?
Spinal transection/injury with loss of sympathetic outflow beneath the level of injury - Vasodilation - Rapid increase in size of the vascular bed - blood is in the peripheries not in the heard and organs - Reduced venous return - less tonal control - Reduced cardiac output
45
NEUROGENIC SHOCK MANAGEMENT ? What are the ABCDE management approaches ?
A. secure airway B. if the injury affects C3-5, the diaphragm may become affected so "3 and 5 keep the diaphragm alive" pt needs ITU admission, careful observation +/- mechanical ventilation C. may be bradycardic, warm peripheries, hypotensive, use of inotropes & vasopressors on ITU D. confused if brain perfusion affected, focal neurological signs (sensory or motor impairment) E. remember to assess anal tone & perineal sensation
46
What should be avoided in Neurogenic shock management?
Avoid large amounts of IV fluid- will lead to pulmonary oedema
47
ANAPHYLACTIC SHOCK: What is the reaction mediated by ? and what does it cause :
- Reactions mediated by IgE from mast cell degranulation Causes : -> Release of histamine and serotonin -> Rapid vasodilation -> Fall in systemic vascular resistance -> Hypotension
48
Presentations of Anaphylactic shock Signs and symptoms:
Skin: itchy skin or a raised red skin rash (hives) and flushing swollen eyes, lips, hands and feet. CNS: feeling lightheaded or faint, unconsciousness, headache and anxiety Swelling of the mouth, throat or tongue, which can cause breathing and swallowing difficulties. wheezing. GI: abdominal pain, diarrhoea, nausea and vomiting Pelvic pain Heart: Slow or fast HR and low BP
49
People with a history of allergies and known triggers are more likely to experience which type of shock?
Anaphylaxis
50
ANAPHYLACTIC SHOCK MANAGEMENT ? What are the steps/actions used in ABCDE approach?
FIRST: Immediately remove the trigger A = manoeuvres/adjuncts/early definitive airway B = high flow O2, examine chest, nebulised bronchodilators C= assess b/p, gain IV access, take bloods Administer: - IM adrenaline 1:1000 0.5mlrepeat every 5 mins - IV chlorphenamine 10mg - IV hydrocortisone 200mg - IV fluids D = assess GCS E= rash, erythema, triggers
51
SEPTIC SHOCK: What if the CONSENSUS CONFERENCE DEFINITIONs for SEPSIS
Systemic Inflammatory Response Syndrome (SIRS) Two or more of: - Pyrexia (>38deg) or hypothermia (<36deg) - Tachycardia (>90bpm) - Tachypnoea (RR >20) - White cell count >12 or <4 - Acutely altered mental state - Blood glucose >6.6 Sepsis = SIRS + documented source of infection
52
What is severe sepsis?
Severe sepsis = SIRS + altered organ perfusion/evidence of dysfunction Including: - CVS (lactate >1.2mmol/L) - Resp (PaO2 <9.3kPa) - Renal (urine output <120ml over 4 hours) - CNS (GCS <15)
53
What is sepsis shock?
Septic shock = refractory hypotension in addition to SIRS, in presence of invasive infection
54
What are the signs/symptoms of sepsis shock? and what are they caused by?
Signs/symptoms caused by the release of endogenous inflammatory mediators (nitric oxide, bradykinin, histamine, prostaglandins & cytokines) --> Vasodilation -->Vessel permeability -->Myocardial depression
55
History may give indication of infective source What history of sign/symptoms are treatments can be used to identify sepsis shock?
--> Breathlessness, productive cough --> Abdo pain, D&V --> Frequency, dysuria, suprapubic pain -->Headache, neck stiffness, coma --> Recent surgery, trauma
56
When should we call for help ? SEPSIS acronym
S = slurred speak E = extreme shivering and muscle pain P = passing no urine S = Severe breathlessness I = It feels like you're going to die S = Skin mottled/ discoloured
57
SEPTIC SHOCK MANAGEMENT: what are the 6 steps? "Sepsis six"
Doing these 6 steps within the first-hour help with survival 1. High oxygen flow 2. Take blood cultures 3. Give IV antibiotics 4. Give a fluid challenge 5. Measure Lactate 6. Measure urine output

HHD 2 and Pharma (2 decks)

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