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purpuric rash,not blanching .fever and painful joints
40 year old female with tonsillitis,
Henoch Schonlein Purpura I
What are the clinical diagnosis of HSP?
Arthritis/ arthralgia
Abdominal Pain
Nephritis
Common org involved in HSP?
Group A Streptococcus
What is the initial management for HSP?
Urinalysis
Blood pressure
What is the most common complication of hSP?
Intussusception
What are the medical management of HSP?
Mild:
Bed Rest
Paracetamol - Ibuprofen / Naproxen
Moderate to Severe pain:
Steroids (glucocorticoids) in children
Oral Prednisolone or IV Methylprednisolone
Nontender soft swelling in the neck
Thyroglossal cysts
Anemia, weight loss
Angular stomatitis
Plummer Vinson Syndrome
What is the confirmatory Test for PVS?
Endoscopy
- to identify the presence of esophageal webs
CI in pregnancy, antidepressant
Paroxtine
Safe in pregnancy, for depression
Escitalopram
positive ANA test in a patient with joint pain
Uveitis
The most common presentation is delayed passage of meconium. Other symptoms can include poor feeding, poor weight gain, progressive abdominal distention, and vomiting
Hirschsprung disease
Hirschsprung disease typically presents with severe constipation or signs of intestinal obstruction. In some cases, the disease may present with ongoing symptoms from early childhood or with the development of functional obstruction, fecal impaction, and megacolon in later life
Definitive Diagnostic Test for Hirschsprung disease
Rectal Biopsy
commonly presented as a useful biomarker for the diagnosis or prognosis of AMI.
Serum lactate (SL)
It can present with a wide range of symptoms, including cough, shortness of breath, chest pain, fatigue, fever, weight loss, and skin rash
. A systolic murmur at the apex may be indicative of cardiac involvement in sarcoidosi
Sarcoidosis
s a liver condition that occurs during pregnancy and is characterized by intense itching (pruritus) and abnormal liver function tests
The itching is often worse at night and can be generalized or localized to the hands and feet
Elevated levels of bile acids in the blood are a hallmark
The yellow tinge of the sclera and abnormal liver function tests, including elevated bilirubin and alkaline phosphatase (ALP), are consistent with the diagnosis
Intrahepatic cholestasis of pregnancy
Systolic murmur at 3rd Left intercostal, fixed split, no cyanosis.
ASD
blood film tear drop cells.
Myelofibrosis, which is a serious bone marrow disorder.
A bone marrow biopsy definitive diagnosis
characterized by the absence of discrete P waves, presence of fibrillatory (f) waves, and an irregularly irregular ventricular rhythm
This irregularity in the R-R interval is a key feature
AF
Presence of anti-neutrophil cytoplasmic antibodies (ANCA), which appear in the blood of most people who have active granulomatosis with polyangiitis
ANCA testing can help support the diagnosis, but it is not specific to granulomatosis with polyangiitis and can also be positive in other forms of vasculitis
Wegener’s granulomatosis
anti-glomerular basement membrane (anti-GBM) antibodies, which lead to the development of glomerulonephritis and pulmonary hemorrhage
Goodpasture syndrome
is a kidney disease characterized by the deposition of immunoglobulin A (IgA) in the glomeruli, leading to glomerulonephritis.
IGA nephropathy
Gram stain showing diplococci is a characteristic finding for Neisseria meningitidis, which is a common cause of bacterial meningitis in adults
a) Neisseria meningitidis.