Side effects Flashcards
(45 cards)
1
Q
Omeprazole (5)
A
Hypomagnesaemia Increased risk c.diff infection Microscopic colitis Hyponatraemia Osteoporosis
2
Q
Adenosine (8)
A
Chest pain Flushing Abdo discomfort Headache Hypotension Dry mouth Dyspnoea Arrhythmias
3
Q
Amiodarone (11)
A
Hypothyroidism Hyperthyroidism Corneal deposits Pulmonary fibrosis Liver fibrosis Photosensitivity Slate grey appearance Bradycardia Lengthens QT Optic neuritis Increased risk idiopathic intracranial hypertension
4
Q
Digoxin (4)
A
Yellow green vision
Gynaecomastica
Anorexia
Confusion
5
Q
Digoxin toxicity (10)
A
Nausea Vomiting Diarrhoea Abdo pain Headache Dizziness Confusion Delirium Vision - blurred, yellow Cardiac - irregular, VT, VF, sinoatrial block, atrioventricular block
6
Q
Ciprofloxacin (5)
A
Increases INR Tendinitis Tendon rupture Lowers seizure threshold Lengthens QT interval
7
Q
Nitrofurantoin (2)
A
Hepatitis
Hepatic failure
8
Q
Trimethoprim (4)
A
Isolated increase in creatinine
Rashes
Pruritic
Suppression of haematopoiesis
9
Q
Amitriptyline (10)
A
Hyponatraemia Abnormal LFTs Leukopenia Thrombocytopenia Drowsiness Dry mouth Blurred vision Constipation Urinary retention Overflow incontinence
10
Q
Sertraline (7)
A
Hyponatraemia GI bleed QT interval prolongation Mania Serotonin syndrome Duodenal ulcer Erectile dysfunction
11
Q
Amlodipine (5)
A
Peripheral oedema Nausea Dizziness/postural symptoms Palpitations Flushing
12
Q
Ramipril (6)
A
Dizziness/postural symptoms Nausea/vomiting Diarrhoea Chest pain Weakness Angioedema
13
Q
Verapamil (4)
A
Constipation
Hypotension
Bradycardia
Flushing
14
Q
Carbamazepine (8)
A
Decreased INR Dizziness + ataxia Drowsiness Headache Visual disturbance Steven Johnson syndrome Leukopenia + agranulocytosis Hyponatraemia secondary to SIADH
15
Q
Phenytoin (9)
A
Cerebellar syndrome Gingival hyperplasia Decreased INR Peripheral neuropathy Megaloblastic anaemia Osteomalacia Lymphadenopathy Dyskinesia Dupuytren's contracture
16
Q
Sodium valproate (9)
A
Increases INR Weight gain Nausea Alopecia Ataxia Tremor Hepatotoxicity Pancreatitis Thrombocytopenia Hyponatraemia
17
Q
Chlorpromazine (typical) (15)
A
Parkinsonism Acute dystonia Akathisia Tardive dyskinesia Increased risk stroke/VTE Dry mouth Blurred vision Urinary retention Constipation Sedation Weight gain Increased prolactin Impaired glucose tolerance Neuroleptic malignant syndrome Prolonged QT
18
Q
Clozapine (atypical) (9)
A
Agranulocytosis Hyperglycaemia QT interval prolongation Sepsis Idiopathic hyperthermia Weight gain Hypersalivation Increased prolactin Extrapyramidal side effects
19
Q
Finasteride (4)
A
Erectile dysfunction
↓ libido
Ejaculation problems
Gynaecomastica
20
Q
Tamulosin (4)
A
Dizziness
Postural hypotension
Dry mouth
Depression
21
Q
Beta blockers (10)
A
Bronchospasm - avoid w/ asthma Erectile dysfunction Constipation Dizziness/postural symptoms Dry mouth Cold hands + feet Vivid nightmares Tiredness Exacerbates plaque psoriasis Insomnia ↓ hypoglycaemic awareness
22
Q
Metformin (4)
A
Lactic acidosis
GI disturbance
Diarrhoea
Bloating
23
Q
DPP4-inhibitors (gliptins) (3)
A
Hypoglycaemia
GI upset
Pancreatitis
24
Q
GLP-1 analogues (atide) (2)
A
Hypoglycaemia
GI upset
25
Acarbose (2)
Flatulence
| GI disturbance
26
SGLT2 (2)
Increased risk UTIs
| Necrotising faciitis of genitalia and perineum
27
SU (azide) (4)
Hypoglycaemia
↑ weight
SIADH
Cholestatic liver dysfunction
28
Thiazolidinediones (6)
```
Fluid retention
↑ weight
Worsening heart failure
Liver dysfunction
Fractures
Bladder cancer
```
29
Bendroflumethiazide (7)
```
GI upset
Headache
Dizziness/postural symptoms
Numbness/tingling
Blurred vision
Hypokalaemia
Hyponatraemia
```
30
Furosemide (7)
```
Sensorineural hearing loss
Hypocalcaemia → osteoporosis
Hypotension
Hyponatraemia
Renal impairment
Gout
Hyaline casts in urine
```
31
Ciclosporin (8)
```
Gum hypertrophy
Hypertrichosis
Hypertension
Hyperkalaemia
Hyperglycaemia
Hepatotoxicity
↑ risk idiopathic intracranial hypertension
SCC or BCC
```
32
Metoclopramide (4)
Can induce oculogyric crisis - dystonic reaction in young women
Galactorrhoea
Raised prolactin
Extrapyramidal effects
33
Rotigotine (parkinsons) (5)
```
Impulse control disorder
Pathological gambling
Hypersexuality
Binge eating
Compulsive shopping
```
34
Ethambutol (4)
Blurry vision
↓ visual acuity
Colour blindness
Optic neuritis
35
Isoniazid (4)
Drug induced lupus
Peripheral neuropathy
Hepatitis
Agranulocytosis
36
Pyrazinamide (4)
Hyperuricemia → gout
Arthralgia
Myalgia
Hepatitis
37
Rifampicin (2)
Hepatitis
| Orange bodily secretions
38
Allopurinol
Bone marrow suppression
39
Azathioprine (4)
Bone marrow depression
Nausea/vomiting
Pancreatitis
↑ risk non melanoma skin cancer
40
Methotrexate (8)
```
Bone marrow suppression
Anaemia
Leucopenia
Agranulocytosis
Thrombocytopenia
Fibrosis in liver + lung
Mucositis
Pneumonitis
```
41
Prednisolone (11)
```
Insomnia
Cushings syndrome
Hirsutism
Osteoporosis
Avascular necrosis of femoral head
Mania
Depression
Psychosis
Peptic ulceration
Acute pancreatitis
Proximal myopathy
```
42
Sildenafil (4)
Headaches
Facial flushing
Dyspepsia
Blue green tingeing of vision
43
Statin (2)
Myopathy - myalgia, myositis, rhabdomyolysis, ↑ CK
| Liver impairment
44
Spironolactone (2)
Hyperkalaemia
| Gynaecomastia
45
Sulphasalazine (6)
```
Rashes
Oligospermia
Headache
Heinz body anaemia
Megaloblastic anaemia
Lung fibrosis
```
