side effects Flashcards

Question

Sulphasalazine side effects?

Answer 1

``` myelosuppression oligospermia hepatitis SJS/erythema nodosum renal failure urine coloured, tears coloured and contacts stained lung fibrosis ```

Answer 2

``` myelosuppression hepatotoxic pneumonitis/fibrosis muscositis = GI and oral inflammation renal failure ```

Answer 3

Bulls eye retinopathy tinnitus myopathy

Answer 4

Nephritis | Triggers myasthenia

Answer 5

reactivate TB infusion reactions (anaphylaxis) autoimmune reactions dyscrasia

Answer 6

haemorrhagic cystitis myelosuppression alopecia

Answer 7

lipohypertrophy hypos hypokalaemia weight gain

Answer 8

``` lactic acidosis weight loss Don't commence with GFR <30 metallic taste GI disturbance B12 deficiency ```

Answer 9

hypoglycaemia | weight gain

Answer 10

fluid retention leading to heart failure fractures hepatotoxic

Answer 11

pancreatitis

Answer 12

``` constipation UTI/thrush Amputations ketoacidosis hypotension hypoglycaemia ```

Answer 13

``` Carbemazepine Colchicine Clozpaine Carbimazole Cytotoxic agents ```

Answer 14

``` sulphonylurea sulphonamides anti-epileptics - phenytoin allopurinol chloroquines mycoplasma NSAIDs ```

Answer 15

``` sulphonamide barbirturates carbamazepine penicillin NSAIDS phenytoin ```

Answer 16

ciclosporin phenytoin CCBs

Answer 17

``` Stomach ulcers Thin skin Edema Right and left heart failure Osteoporosis Immunosuppression Diabetes and hyperglycaemia Syndrome Cushings ```

Answer 18

long term steroids chemotherapy trauma alcohol excess

Answer 19

prolonged QT, temperature derangement

Answer 20

tremor, dysarthria

Answer 21

arrhythmias, seizures, coma and renal failure.

Answer 22

increased parasympathetic activity as the acetylcholinesterase inhibited

Answer 23

hypothyroidism diabetes insipidus diarrhoea

Answer 24

psychosis and cognitive impairment in elderly

Answer 25

``` tremor interstitial nephritis hypertrichosis gum hyperplasia burning in hands and feet ```

Answer 26

avoid UV light

Answer 27

red urine postural hypotension dyskinesia on/off effects

Answer 28

tinnitus | hyponatraemia and hypomagnesaemia

Answer 29

``` thyroiditis pulm fibrosis peripheral neuropathy slate grey skin myopathy ```

Answer 30

xanthopsia | arrythmia

Answer 31

``` co-amoxiclav chlorpromazine carbamazepine clarythromicin contraceptives fluCoxacillin sulphonylurea/sulphonamides ```

Answer 32

``` BDAMNS Bleomycin Digoxin Amiodarone Methotrexate Nitrofurantoin Sulfasalazine ```

Answer 33

MVP CLAN Antibiotics - metronidazole, nitrofurantoin, isoniazid Cancer - vincristine, cisplatin amiodarone, phenytoin

Answer 34

trimethoprim | cimetidine/ranitidine

Answer 35

Amiodarone Lithium PTU/radioiodine Carmbimazole

Answer 36

thiazide diureteics | lithium

Answer 37

``` ACEinhibitors K sparing diuretics NSAIDs trimethoprim tacrolimus/ciclosporin heparin ```

Answer 38

loop diuretics bisphosphonates phenytoin

Answer 39

``` PPI SSRI Dirutetics Ace inhibitors Chlorpromazine Carbemazepine ```

Answer 40

Folate synthesis blockers - methotrexate, trimethoprim, sulphonamides B12 deficiency causes - metformin Alcohol Sodium valproate, phenytoin, antidepressants

Answer 41

``` PC BRAS +st johns wort Phenytoin Carbemazepine Barbiturates Rifampicin Alcohol acute SulphonylUreas (inducer) ```

Answer 42

``` AO DEVICES +grapefruit Allopurinol Omeprazole Disulfiram Ethanol acute Valproate Isoniazid Ciprofloxacine Erythromycin Sulphonamide ```

Answer 43

``` COW PATS Carbemazepine, Ciclosporin, Citalopram Oral contraceptives Warfarin Phenytoin Acetylcholinesterase inhibitors Theophylline Statin, steroids ```

Answer 44

``` protein bound drugs normally fight when available space is sparse Phenytoin BZB Digoxin NSAIDs Furosemide Warfarin Amiodarone Sulfonylura/sulphonamide Statin ```

Answer 45

NSAIDs beta-blockers adenosine

Answer 46

``` nsaids steroids CCBs pioglitiazone flecainide ```

Answer 47

CCBs | naproxen