Sjogren's Syndrome Flashcards
Genetic basis for SS
MHC2
HLA DR3
Two characteristic pathological findings in SS
Mononuclear Infiltrate
Focal periducal infiltrate
Other manifesations of dry eye (sicca)
Dryness, grittiness, foreign body
Rope Like secretions
Corneal erosions
Tear measurement for SS
Schirmer testing
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Xerostomia rate
93.5%
Increased ____ is a complication of xerostomia
increased amount of dental caries
Salivary flow is measured by ______
Other diagnostic test for dry mouth
Sialometry
Minor salivary gland biopsy
Extraglandular SS Symptoms (8 categories)
Neurologic involvement (periph neurop, Other neuropathy, CNS lesions, dementia)
Fatigue
Hematologic (Lymphoma–5% of SS patients)
Arthritic
Dermatologic (vasculitis)
Pulmonary (xerotrachea, pneumonitis –> fibrosis, alveolitis, pseudolymphoma)
GI
Renal - tubular, glomerulonephritis
Predictors of Lymphoma (7)
Chronic enlargement of parotid gland splenomegaly + lymphadenopathy Palpable purpura Leg ulcers Low C4 Mixed monoclonal cryoglobulinemia Monoclonal Rheumatoid factors
Gold standard for SS diagnosis
minor salivary gland biopsy
Autoantibodies in SS
SS-A
SS-B
DDx for xerostomia
Amyloidosis DM Sarcoid virus trauma radiation *Drugs
DDx Dry eyes
Amyloid Stevens-Johnson corneal anesthesia Blinking problems eyelid scarring trauma
Parotid swelling
Acromegaly, gonadal hypofuntion
Metabolic diseasse (pancreatitis, DM, cirrhosis)
Viral infections (HIV, hepatitis mumps)
____ used to stain damaged corneal and corneal cells
Rose Bengal
