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PBR: Rheumatology > Sjogren Syndrome > Flashcards

Flashcards in Sjogren Syndrome Deck (10)
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1
Q

What is Sjogren syndrome?

A

A rare autoimmune exocrinopathy that causes a combination of symptoms/signs; dry eyes and dry mouth are the most notable.

2
Q

Name the diagnostic criteria for Sjogren syndrome.

A

Inflamed and dry eyes (keratoconjunctivitis sicca); dry mouth (xerostomia); lymphocytic infiltrate on minor salivary gland biopsy; and laboratory evidence of the following: RF+, ANA+, or Ro+ or La+ antibodies.

3
Q

Which antibodies are frequently present in pediatric Sjogren syndrome?

A

Ro+ (SSA; 70%) and La+ (SSB; 50%) antibodies

4
Q

How do most pediatric cases of Sjogren syndrome present?

A

Most cases present with recurrent parotitis and keratoconjunctivitis sicca.

5
Q

What is the ratio of males:females diagnosed with Sjogren syndrome?

A

The female:male ratio is 3:1

6
Q

Differentiate primary from secondary Sjogren syndrome.

A

Primary Sjogren syndrome is defined as an isolated disorder, while secondary SS is associated with another autoimmune disease. Some children with a diagnosis of primary SS go on to develop another autoimmune disorder, most commonly SLE.

7
Q

What is the recommended treatment for symptomatic patients with Sjogren syndrome?

A

Treat with agents that increase moisture: artificial tears, artificial saliva, and pilocarpine to stimulate exocrine secretions. Chewing sugarless gum can help stimulate salivary flow as well.

8
Q

How often should patients with Sjogren syndrome be seen by the dentist?

A

At least 2-3x/year, due to marked increase in caries from decreased salivation.

9
Q

Which malignancies are patients with Sjogren syndrom at risk for?

A

Lymphoma, especially mucosal associated lymphoid tissue lymphoma (MALT) and non-Hodgkin B-cell lymphomas.

10
Q

Infants born to mothers with Sjogren syndrome are at risk for development of what condition?

A

Children born to mothers with Sjogren syndrome who have Ro and/or La antibodies are at risk for developing neonatal lupus.