Skeletal

Question 1

Name the Spasmolytics /Antispasmodics

• Chronic CNS actions (4)
• Chronic Muscle Action (2)
• Acute Use (1)

Answer 1

• Baclofen, Diazepam, Tizandine, Cyclobenzaprine
• Dantrolene, Botulism
• Cyclobenzaprine

Question 2

Spasmolytics treat 2 conditions
• Spasticity from _____ motor neuron lesions (spasmolytics)
Spasms from _______ musculoskeletal condtitions

Answer 2

• Upper

* Peripheral

Question 3

What is the site of Spasmolytic action?

Answer 3

GABA receptors

Question 4

• Which medication is centrally acting, inhibits spinal motor neurons by decreasing excitatory trasnmitters?

Answer 4

• Baclofen - GABA receptor for pain

Question 5

• What is the use of Baclofen?

Answer 5

Severe spasticity from Cerebral palsy, multiple sclerosis, or Stroke

Question 6

• Which medication is a central acting, is a GABA enhancer, and causes Central sedation and inhibits primary motor afferent in spinal cords

Answer 6

• Diazepam

Question 7

• What is Diazepam used for?
• Where is Diazepam metabolized
• What are adverse effects of Diazepam

Answer 7

• Spasm from MS, CVA, ALS
• Liver = Hepatic metabolism
• Sedation, Antegrade amnesia, Addictive

Question 8

• What drug inhibits motor reflex outputs, is an Alpha 2 Agonist in the spinal cord
• Is used to treat MS, CVAs, and ALS

Answer 8

• Tizanidine

Question 9

• Where is Tizanidine metabolized.

* What are Tizanidine’s 3 ADEs?

Answer 9

• Renal and Hepatic elimination.

* (SHoW) Sedation, HoTN, Weakness

Question 10

• What is Cyclobenzaprine used for?
• Where is Cyclobenzaprine metabolized
• What are adverse effects of Cyclobenzaprine

Answer 10

• Only Acute spasms from muscle injury or inflammation
• Hepatic metabolism
• Strong Antimuscarinic = Dumb as a bitch + ocular effects

Question 11

• What are the antispasmodic drugs?

CCOMM

Answer 11

(CCOMM)
• Carisoprodol (Soma)
• Chlorzoxazone
• Orphenadrine
• Metazalone
• Methocarbamol

Question 12

What do the Antispasmodics?

Answer 12

• Acute muscle spams relief

Question 13

• What is Carisoprodol drug classification? (Car ->Mepro -> extensive withdrawal sxs)
• How can you limit these sxs?

Answer 13

• Schedule IV: metabolized to meprobamate (another Class IV) which is a central muscle relaxant.
• Taper over 14 days

Question 14

• What drug blocks RyR1 Ca channels in the sacroplasmic reticulum in skeletal muscle, and Weakens muscle contraction due to few myosin-actin

Answer 14

• Dantrolene

Question 15

• What is Dantrolene used for?

Answer 15

• Malignant Hyperthermia (IV)

* Spasm due to Cerebral Palsy, SCI, MS

Question 16

• What is botulism used for?

Answer 16

• Cleaves fusion proteins in nerve ending = Flaccid paralysis

Question 17

• F/T: Botulism is used for cerebral palsy spasm, MS, Overactive bladder, Migraine?

Answer 17

True