Skin Flashcards
(44 cards)
Which layer of the skin has desmosomes?
stratum spinosum
atopic dermatitis is what type of HSR?
type I
What are munroe abscesses?
neutrophils in the corneum
-diapedesis occurs at dermal papilla rather than Post cap venule
- seen in psoriasis
What is an auspitz sign?
pinpoint bleeding occurs when psoriatic scale is picked off
What disease is lichen planus associated with?
Hep C
What disease has the 4 “P”s and what are they?
Lichen Planus
- Pruitic
- polygonal
- purple
- papules
In ichthyosis vulgaris what is defective? what is seen histologically?
dec synthesis of profillagrin
- corneum is loose
- granulosum is absent
In x-linked ichthyosis what is deficient? what therefore occurs?
steroid sulfatase
-persistence of cohesion in corneum
What is mutated in lamellar ichthyosis?
TGM1
In darier disease what is mutated and what therefore occurs?
ATP2A2 is mutated - ca2+ dependent assembly of desmosomes is messed up
- multifocal keratoses
- skin colored papules that become encrusted
What causes pemphigus vulgaris?
IgG against desmoglein
- Type II HSR
- acantholysis of stratum spinosum
Describe the nature of the blisters in pemphigus vulgaris?
thin walled bullae that rupture easily
-suprabasal - intraepidermal
What is affected in EB simplex?
cytokeratin IFs
-blisters develop in response to minor trauma
Where does cleavage occur in Junctional EB? What molecule is affected?
- lamina lucida
- Benign: mutation in XVII collagen
severe: laminin and integrin
Where is the split in dermolytic EB and what molecule is affected?
anchoring fibrils
-entire BMZ and epidermis splits
What is the mutation in kindler syndrome and where is the cleavage?
- mutation in FERMT1
- mixed cleavage planes
What causes bullous pemphigoid? where are the blisters?
IgG against hemidesmosomes
- subepidermal blisters
- oral mucosa is spared!
- primarily thighs and trunk
What type of blisters occur in bullous pemphigoid?
tense bullae that dont rupture easily
What causes dermatitis herpetiformis?
igA at tips of dermal papillae
What is the signature rash in erythema multiforme?
targetoid rash with bullae
What is steven johnson syndrome?
severe EM with oral involvement and fever
What is the appearance of a seborrheic keratosis nodule?
“coin stuck on appearance”
-raised discolored plaque
What is the typical word used for the histology of seborrheic keratosis?
pseudocysts
What is leser trelat sign?
sudden onset of multiple seborrheic keratoses
-sign of GI tumor
