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Dermatology > Skin and Systematic Disease > Flashcards

Skin and Systematic Disease Flashcards

1
Q

Hereditary haemorrhagic telangiectasia is a sign of what?

A

Genetic GI conditions

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2
Q

Patient presents with hard blue lumps on the skin has what? What is a sign of?

A

Blue rubber bleb naevus

Sign of GI haemorrhage

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3
Q

What skin lesions are suggestive of GI inflammatory/autoimmune disease?

A

Erythema nodosum

Pyoderma gangrenosum

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4
Q

Pyoderma gangrenosum is suggestive of what?

A

Inflammatory bowel disease

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5
Q

How is Pyoderma gangrenosum investigated?

A

Biopsy of the edge

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6
Q

Red, inflamed gums are suggestive of what?

A

Vitamin C deficiency

Vitamin B1 deficiency

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7
Q

What are the dermatological signs of diabetes?

A 
Acanthosis nigricans
Diabetic bullae
Diabetic dermopathy
Eruptive xanthomas
Necrobiosis lipoidica
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8
Q

What is thyroid acropachy?

A

Clubbing

Soft tissue swelling of hands

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9
Q

Thyroid acropachy is a sign of what?

A

Hyperthyroidism

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10
Q

What is pretibibial myxoedema a sign of?

A

Hypothyroidism

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11
Q

How does cutaneous lupus present?

A

Butterfly rash
Plaques with clear margins
Photosensitivity
Negative antibodies

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12
Q

What is the cause of alopecia?

A

T-lymphocyte, cytokine rejection of hair

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13
Q

What is the cause of vitiligo?

A

Autoimmune destruction of melanocytes

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14
Q

What is the cutaneous presentation of carcinoid syndrome?

A

Episodic flushing without sweating

Facial telangiectasia

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15
Q

How does carcinoid syndrome present differently do menopause?

A

Episodic flushing WITHOUT menopause

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16
Q

What is ectopic ACTH syndrome?

A

Tumour production of ACTH leading to hyperpigmentation

17
Q

What is paget’s disease?

A

Eczematous plaques of nipple/areola

Extension of underlying ductal adenocarcinoma

18
Q

What is extra-mammary paget’s disease?

A

Usually axilla, uro-genital areas

Intraepithelial adenocarcinoma

19
Q

What is paraneoplastic pemphigus?

A

Erosive stomatitis rash
Non-hodgkins
Castleman’s disease

20
Q

What is hypertrichosis lanuginosa?

A

Acute onset of lanugo hairs on face/body

21
Q

Hypertrichosis lanuginosa is associated with what?

A

Colorectal cancer
Lung
Breast

22
Q

What is Erythema Gyratum Repens?

A

Concentric erythematous lesions

23
Q

Erythema Gyratum Repens is associated with what?

A

Lung cancer
Oesophageal, breast
Mycobacterial infection (rare)
Pregnancy (rare)

24
Q

What is Bazex syndrome?

A

Symmetrical hyperkeratosis

25
Q

Bazex syndrome is associated with what?

A

Small cell carcinoma

26
Q

What is Leser-Trelat syndrome?

A

Eruptive seborrhoeic keratosis

GI adenocarcinomas

27
Q

What is acanthosis nigricans?

A

Brown scaly skin

28
Q

Acanthosis nigricans is a sign of what? When should you be concerned?

A 
Gastric adeocarcinoma
Older patients
Rapid onset
Involves lips
Weight loss
29
Q

What is dermatomyositis?

A 
Inflammatory myopathy + rash
Photosensitive rash
Joints of the hand
Cheeks
Upper back
Gottron's papules
Shawl sign
30
Q

What are Gottron’s papules?

A

Red maculo-papular lesions over bony prominences

31
Q

Dermatomyositis is associated with what?

A

Ovarian
Breast
Lung cancer

32
Q

How does Howel-Evans syndrome present?

A

Palmoplantar keratoderma (skin expansion on hands and feet)

33
Q

How does neurofibromatosis present?

A

Cafe-au-lait
Ax freckles
Neurofibromas

34
Q

How does Peutz-Jeghers syndrome present?

A

Melanosis

Colon hamartomas

35
Q

How does Muir-Torre syndrome present?

A

Sebaceous tumours

Keratoacanthomas

36
Q 
Bullous pemphgoid
Sweets Syndrome
Pyoderma gangrenosum
Acquired ichthyosis
Cryoglobulinaemia
Are all associated with what?
A

Malignancy

Dermatology (8 decks)

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