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ABSITE > Skin & Soft Tissue > Flashcards

Skin & Soft Tissue Flashcards

1
Q

What is associated with decreased hernia recurrence: prosthetic or synthetic mesh?

A

Prosthetic mesh

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2
Q

Which has less immunoreactivity: synthetic or biologic mesh?

A

Biologic

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3
Q

When to use synthetic mesh for hernias?

A

Wound class 1-2

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4
Q

When to use biologic mesh for hernias?

A

Wound class 3-4 if defect is >3cm

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5
Q

At what point does a wound reach 60% of its final tensile strength?

A

6 weeks

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6
Q

At what time does a wound reach its greatest tensile strength?

A

8 weeks

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7
Q

What type collagen is initially present in healing wounds?

A

Type III collagen

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8
Q

What type of collagen provides the final tensile strength of the wound?

A

Type I collagen

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9
Q

What cells mediate wound contraction?

A

Myofibroblasts (mainly found at edges)

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10
Q

What factors stimulate wound contraction?

A

PDGF-AB and BB released by platelets and macrophages

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11
Q

When does wound contraction begin?

A

After 4-5 days

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12
Q

What factors are released by macrophages in early stages of wound healing?

A

IL-1, IL-6, IL-8, and TNF-a

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13
Q

When is the maximum collagen accumulation in a wound?

A

3 weeks after injury

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14
Q

Initial treatment of frostbite grade I

A

Moist reheating using whirlpool bath

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15
Q

What mediates the release of platelet-aggregating factor from platelets?

A

Leukotrienes

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16
Q

What virus is associated with merkel cell carcinoma

A

Polyomavirus

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17
Q

Most common induction agent for immunosuppression after kidney transplant

A

Thymoglobulin

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18
Q

Diagnosis of a burn infection

A

10^5 bacteria/gm of tissue from wound culture

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19
Q

Treatment of stretch marks

A

Reconstructive therapy or laser therapy

20
Q

Treatment for superficial partial thickness burn of the face

A

Neomycin or polymyxin B

21
Q

Treatment of a partial thickness burn

A

Silver sulfadiazine or silver nitrate

21
Q

Treatment of a full thickness burn

A

Mafenide acetate (can penetrate eschar)

22
Q

Which burn treatment causes metabolic acidosis

A

Mafenide acetate

23
Q

Which burn treatment causes nephrotoxicity

A

Bacitracin

24
Q

Which burn treatment causes methemoglobinemia

A

Silver nitrate

25
Q

Which burn treatment causes hyponatremia

A

Silver nitrate

26
Q

Which burn treatment causes transient neutropenia

A

Silver sulfadiazene

27
Q

Which transplant med: nephrotoxicity, hypertension, gingival hyperplasia, hirsutism

A

Cyclosporine

28
Q

Which transplant med: nephrotoxicity, alopecia, hypertension, diabetogenic

A

Tacrolimus

29
Q

Which transplant med: hepatotoxicity, BM suppression, leukopenia

A

Azathioprine

30
Q

Which transplant med: nausea, diarrhea, abdominal cramps, hepatotoxicity, leukopenia

A

Mycophenolate

31
Q

Which transplant med: anemia, hyperlipidemia, thrombocytopenia, poor wound healing

A

Sirolimus

32
Q

Familial atypical multiple mole syndrome - what cancers are they at risk for

A

Melanoma (100% lifetime risk) and pancreatic cancer

33
Q

Management of paronychia

A

I&D, clindamycin

34
Q

Pathophysiology of GVHD

A

Activation and differentiation of donor cells into Th1 and Th17 lineages

35
Q

When do you do a deep inguinal lymphadenectomy for melanoma?

A

If Cloquet’s node (first of the deep nodes) is positive

36
Q

What is the most prevalent type of skin cancer

A

Basal cell carcinoma

37
Q

Gorlin syndrome

A

Multiple basal cell carcinomas, spine/jaw anomalies, pitting of palms and soles

38
Q

What is the endpoint for resuscitation for burn patients

A

Urine output

39
Q

Parkland formula

A

4mL/kg of %BSA
Half in first 8 hrs
Other half in next 16 hrs

40
Q

What surgical margins are needed for basal cell cancer

A

4mm

41
Q

Surgical margins for subungual melanoma at the finger

A

Amputation at mid proximal phalanx

42
Q

Surgical margins for subungual melanoma of the toe

A

Toe amputation including metatarsal head

43
Q

Melanoma in inguinal region with positive sentinel lymph node biopsy - what is the next step?

A

US surveillance of inguinal region q3mo

44
Q

What is the defect in classical type of Ehlers Danlos

A

Type V collagen

45
Q

Indications for adjuvant radiation for trunk and extremity soft tissue sarcoma: high grade, large (>5cm), or close margins

A

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