Skin + Soft tissue Infections Flashcards

(44 cards)

1
Q

What are the skin compartments (layers)?

A
Epidermis
Dermis
Subcutaneous fat
Fascia
Muscle
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2
Q

What factors need to be considered when there is an infection?

A

The site, organism, host and environment

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3
Q

What is the significance of site of infection?

A

Possible complications with specific sites eg. face

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4
Q

What hosts are important to consider in an infection?

A
Diabetics - leads to neuropathy/ vasculopathy
Immunosuppressed
Renal failure
Milroy's disease
Predisposing conditions
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5
Q

What factors are there to consider with environment?

A

Drug-resistant strains e.g. MRSA
Drug interactions
Drug allergies

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6
Q

What are the features of impetigo?

what is the causative organism

A

Superficial skin infection due to Staph Aureus

  • multiple vesicular lesions on erythematous base
  • highly infectious
  • occurs on exposed body parts: face, extremities
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7
Q

What predisposing factors are there?

A
skin abrasions
minor trauma
burns
poor hygiene
insect bites
chickenpox
eczema
atopic dermatitis
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8
Q

What is the treatment for impetigo?

A

small areas = topical antibiotics

large areas = oral + topical antibiotics

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9
Q

What are the features of erysipelas?

what is the causative organism

A

infection of upper dermis - face + limbs

raised, painful, red area
fever
regional lymphadenopathy

Caused by strep pyogenes

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10
Q

What are the features of cellulitis?

what is the causative organism

A

Diffuse skin infection of dermis + epidermis
Spreading erythematous area with no distance border
Fever

Cause: strep pyogenes + staph aureus

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11
Q

What are the predisposing factors to cellulitis?

A

diabetes
tinea pedis
lymphoedema

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12
Q

What is the treatment for cellulitis?

A

Combination of anti-staphylococcal and anti-streptococcal antibiotics

In extensive disease, admission for intravenous antibiotics and rest

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13
Q

What hair associated infections are there?

A

Folliculits
Furunnculosis
Carbuncles

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14
Q

What are the features of folliculitis?

what is the causative organism

A

Pustular infection of a hair follicle

Typically found on head, back, bum, extremities

Cause= staph aureus

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15
Q

What are the features of furunculosis?

what is the causative organism

A

=Boils

inflammatory infection of a hair follicle
extends into dermis + subcutaneous tissue

Affects hair areas: face, axilla, neck, buttocks

Cause= staph aureus

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16
Q

What are the risk factors for furunculosis?

A
Obesity
Diabetes
Atopic dermatitis
Chronic kidney disease
Corticosteroid use
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17
Q

What are the features of a carbuncle?

A

Occurs when infections involves MULTIPLE FURUNCLES

= multiseptated large abscesses
located on back of neck, thigh etc

May drain spontaneously: purulent material
Constitutional symptoms common e.g. fever

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18
Q

What is the treatment for hair-associated infections?

A
Folliculitis= no Tx or topical antibiotics
Furunculosis= no Tx or topical antibiotics
Carbuncles= admission to hospital, surgery, IV antibiotics
19
Q

What are the features of necrotising fasciitis?

A

Infectious disease emergency
Can affect any site

Red erythema -> oedema and severe pain
Systemic features: hypotension, multiorgan failure

Surgical review is mandatory
Skin necrosis can develop

20
Q

What are the predisposing conditions to necrotising fasciitis?

A
Diabetes
Surgery
Trauma
Peripheral vascular disease
Skin popping
21
Q

What are the types of necrotising fasciitis?

A

Type 1= mixed aerobic + anaerobic (e.g. diabetic foot infection)

Type 2= mono microbial (associated with strep pyogenes)

22
Q

What is the treatment for necrotising fasciitis?

A

Broad spectrum antibiotics:
Flucloxacillin
Gentamicin
Clindamycin

23
Q

What are the features of pyomyositis?

What are the common sites?

What is the causative organism?

A

Purulent infection within striated muscle
Manifests as an abscess
Often secondary to damaged muscle

Common sites: thigh, cold, arms, gluteal region, chest wall

cause= staph aureus

24
Q

What are the symptoms of pyomyositis?

A

Fever, pain
If untreated can lead to septic shock and death

Surgery may be needed

25
What are the predisposing factors of pyomyositis?
``` Diabetes HIV/ immunocompromised IV drug user Rheumatological disease Malignancy Liver cirrhosis ```
26
What is the treatment of pyomyositis?
first, CT/MRI then | treatment= drainage with antibiotic Tx depending on gram stain + culture results
27
What are the features of septic bursitis?
Located subcutaneously between bony prominences e.g. patellar or olecranon bursitis Fever + pain on movement Facilitate movement with reduced friction Infection is often from adjacent skin infection
28
What are the predisposing factors to septic bursitis?
``` Rheumatoid arthritis Alcoholism Diabetes IV drug use Immunosuppression Renal insufficiency ```
29
What is the cause of septic bursitis? How is it diagnosed?
``` Diagnosis= aspiration of fluid Cause= staph aureus ``` Rarer organisms: gram negatives, mycobacteria
30
What are the features of infectious tenosynovitis? What is the causative organism?
Infection of the synovial sheet that surrounds tendons (most commonly tendons in hand) cause= staph aureus, strep pyogenes presents: erythematous swelling of finger Finger held in a semi flexed position Needs urgent review by hand surgeon + antibiotics
31
What are the features of toxin mediated syndromes?
Due to superantigens Dysfunction of immune system activation (not enough T cells activated)
32
What are the causative organisms and features of Toxic shock syndrome toxin 1?
Staph aureus and strep pyogenes causes toxin syndrome which manifests as fever, rash, hypotension and organ failure associated with high-absorbency tampons
33
What are the differences between staphylococcal and streptococcal toxic shock syndrome (TSS)?
Staphylococcal: 3 of following involved: liver, blood, renal, GI, CNS, muscular There is development of antibody to toxin during recovery Streptococcal: mortality rate is much higher (50%) treatment requires urgent surgical debridement
34
What is the treatment of TSS
* Remove offending agent (tampon) * Intravenous fluids * Inotropes (to increase HR/BP) * Antibiotics * Intravenous immunoglobulins
35
What is staphylococcal scalded skin syndrome? what is the Tx?
Infection due to exfoliative toxin A or B commonly affects children Characterised as widespread bullae and skin exfoliation Tx= IV fluids + antibiotics
36
What is Panton-Valentine leucocidin toxin? what is the Tx?
Caused by staph aureus, cause recurrent boils and haemorrhagic pneumonias affects children + young adults Tx= antibiotics the reduce toxin production
37
What are the features of Cannula associated infections?
Nosocomial infection Starts as local inflammation, progresses -> cellulitis -> necrosis common to have bacteraemia
38
What are the risk factors for cannula/venous associated infections?
Continuous infusion > 24 hours Cannula in situ > 72 hours Cannula in lower limb Patients with neurological problems
39
What are the causative organisms of cannula/venous associated infections?
Staph aureus: MSSA (methicillin sensitive SA) MRSA
40
What is the diagnosis and treatment for cannula associated infections?
``` Dx= clinically or positive blood cultures Tx= remove cannula, antibiotics for 14 days, echocardiogram (can lead to endocarditis) ```
41
What is the prevention for cannula associated infections? Note prevention is more important
–Do not leave unused cannula –Do not insert cannulae unless you are using them –Change cannulae every 72 hours –Monitor for thrombophlebitis Use sceptic technique when inserting cannula
42
What surgical site infections are there? | classification
Class 1= Clean wound infections: - Infections in a surgical site that is sterile (example joint operations). - Normally due to invasive organisms such as Staph aureus Class 3= Contaminated wound infections: - Infections at a surgical site that is either already contaminated at the start of surgery or contaminated during surgery e.g. spillage of GI fluid - Role of coliforms or anaerobic organisms
43
What is the diagnosis and treatment for surgical site infection?
MRSA important source of infection • Importance of culturing all clean wound infections Consider unlikely pathogen is cause is from a sterile site e.g. bone infection • Treatment according to sensitivities
44
What risk factors are there for surgical site infections?
Patient associated: diabetes, smoking, obesity, malnutrition, steroid use Procedural: shaving of site prior to procedure, improper pre-op skin preparation, improper antimicrobial prophylaxis, break in sterile technique, inadequate theatre ventilation