Skin V

Question 1

cat-scratch disease is caused by which organism?

Answer 1

cat-scratch disease is caused by B. henselae

Question 2

in ____ patients, baciliary angiomatosis can occur

Answer 2

in AIDS patients, baciliary angiomatosis can occur

Question 3

describe the clinical presentation of cat-scratch disease

Answer 3

• self-limited regional lymphadenopathy
• persistent infection of erythrocytes and endothelial cells
  
  • can trigger proliferation of endothelial cells (vascular tumor formation)

Question 4

in cat-scratch disease, there is self-limited regional _____

Answer 4

in cat-scratch disease, there is self-limited regional lymphadenopathy

Question 5

in cat scratch disease, there is persistent infection of ___ and ___ cells

Answer 5

in cat scratch disease, there is persistent infection of erythrocytes and endothelial cells

Question 6

the persistent infection of ____ cells in cat scratch disease can lead to ____ formation

Answer 6

the persistent infection of endothelial cells in cat scratch disease can lead to vascular tumor formation

Question 7

upon physical examination of a patient with cat scratch disease, there is an enlarged ____

Answer 7

upon physical examination of a patient with cat scratch disease, there is an enlarged spleen

Question 8

_____ testing is confirmatory of cat scratch disease

Answer 8

serologic testing is confirmatory of cat scratch disease

Question 9

describe the DNA virus classification tree

Answer 9

Question 10

describe the RNA virus classification tree

Answer 10

Question 11

list the 2 diseases that have a centripetal rash

Answer 11

rubella and measles

Question 12

list the 2 diseases that have a centrifugal rash

(centrifugal = fugitive = going outwards)

Answer 12

roseola and chickenpox

Question 13

describe the viral classification of Rubeola virus

Answer 13

large, enveloped, (-) ssRNA

Question 14

Rubeloa virus is part of the ____ family

Answer 14

Rubeloa virus is part of the Paramyxoviridae family

Question 15

list the important envelope proteins present on Rubeola virus

Answer 15

• F (fusion) protein:
  
  • fusion to host cell membranes, viral penetration and hemolysis
• H (hemagglutinin) protein:
  
  • adsorption of virus to cells (NO neuraminidase)

Question 16

Rubeola does NOT contain ___ as an envelope protein

Answer 16

Rubeola does NOT contain neuraminidase as an envelope protein

Question 17

list the 4 C’s of measles

Answer 17

• cough
• coryza
• conjunctivitis (with photophobia)
• Coplik spots (Koplik)

Question 18

____ rash appears after Koplik’s spots dissappear

Answer 18

maculopapular rash appears after Koplik’s spots dissappear

Question 19

in measles, the rash that forms is described as (centripetal or centrifugal?)

Answer 19

in measles, the rash that forms is described as centripetal

Question 20

in measles, there is generalized ____ and a complication is lifelong ____

Answer 20

in measles, there is generalized lymphadenopathy and a complication is lifelong disabilities (brain damage, blindness, deafness)

Question 21

the rash seen in measles is caused by ___ damage of ____ cells

Answer 21

the rash seen in measles is caused by cytotoxic T cell damage of infected endothelial cells

Question 22

the measles virus binds to ___ of most cells

Answer 22

the measles virus binds to CD46 of most cells

Question 23

the measles virus infects ____ lymphocytes and dendritic cells, followed by virus transmission to ____ expressing epithelial cells (skin)

Answer 23

the measles virus infects CD150 lymphocytes and dendritic cells, followed by virus transmission to nectin-4 expressing epithelial cells (skin)

Question 24

measles causes immunosuppression during the infection, but after resolution, there is _____

Answer 24

measles causes immunosuppression during the infection, but after resolution, there is lifelong immunity

Question 25

prevention of measles is via a \_\_\_\_

Answer 25

prevention of measles is via a **live attenuated vaccine**

Question 26

describe the Sketchy in relation to measles

Answer 26

Question 27

Rubella (German measles) is part of the ___ family of viruses

Answer 27

Rubella (German measles) is part of the **togaviridae** family of viruses **enveloped +ssRNA**

Question 28

describe the viral composition of Rubella virus

Answer 28

**enveloped, (+)ssRNA**

Question 29

the clinical presentation of rubella is very \_\_\_, but has a characteristic _____ lymphadenopathy

Answer 29

the clinical presentation of rubella is very **mild**, but has a characteristic **postauricular** lymphadenopathy

Question 30

the rash seen in rubella spreads in a (centripetal or centrifugal?) pattern

Answer 30

the rash seen in rubella spreads in a **centripetal** pattern

Question 31

describe the birth defects that can occur from Rubella

Answer 31

growth retardation, **cataracts**, **deafness**, **congenital heart defects** I (eye) ♥ Ruby Earrings

Question 32

rubella is transmitted via \_\_\_\_

Answer 32

rubella is transmitted via **aerosol droplets**

Question 33

diagnosis of rubella is by seeing a 4x increase in ___ or \_\_\_\_

Answer 33

diagnosis of rubella is by seeing a 4x increase in **IgG antibody** or **IgM (+)**

Question 34

in pregnant woman with history of contact with rubella, ___ can be recommended it can reduce symptoms but DOES NOT eliminate the possibility of the baby developing congenital rubella syndrome

Answer 34

in pregnant woman with history of contact with rubella, **hyperimmune globulin** can be recommended it can reduce symptoms but DOES NOT eliminate the possibility of the baby developing congenital rubella syndrome

Question 35

Answer 35

Question 36

roseola infantum virus is part of the ____ family of viruses

Answer 36

roseola infantum virus is part of the **Herpesvirus** family of viruses ## Footnote **enveloped dsDNA**

Question 37

the rash seen in roseola is described as (centripetal or centrifugal?)

Answer 37

the rash seen in roseola is described as **centrifugal**

Question 38

roseola infantum can cause febrile \_\_\_\_

Answer 38

roseola infantum can cause febrile **seizures**

Question 39

in roseola infantum, there are pink ___ and ____ surrounded by white \_\_\_\_

Answer 39

in roseola infantum, there are pink **macules** and **papules** surrounded by white **halos**

Question 40

roseola infantum replicates in ___ and \_\_\_

Answer 40

roseola infantum replicates in **leukocytes** and **salivary glands**

Question 41

roseola uses ___ to enter leukocytes

Answer 41

roseola uses **CD46 protein** to enter leukocytes

Question 42

roseola uses ___ to enter leukocytes

Answer 42

roseola uses **CD46** to enter leukocytes

Question 43

Fifth disease is caused by \_\_\_\_ describe the viral composition

Answer 43

Fifth disease is caused by **Parvovirus B19** ## Footnote **non-enveloped, linear ssDNA icosahedral**

Question 44

erythema infectiosum causes a ____ appearance on the face of children while adults might have ____ and swelling

Answer 44

erythema infectiosum causes a **"slapped cheek"** appearance on the face of children while adults might have **joint pain** and swelling

Question 45

the receptor for Fifth disease (erythema infectiosum) is the ___ located on the \_\_\_\_

Answer 45

the receptor for Fifth disease (erythema infectiosum ) is the **P antigen** located on the **erythrocyte precursor**

Question 46

Fifth disease can be serious in pregnant women, where it can cause severe ___ in newborns or it can also cause \_\_\_

Answer 46

Fifth disease can be serious in pregnant women, where it can cause severe **anemia** in newborns or it can also cause **miscarriage**