Slattery Seizures

Question 1

Phenobarbital - you better get this right

What seizures?

Answer 1

Increase DURATION of GABA mediated Cl- channel opening

Simple, complex, tonic clonic

Question 2

Diazepam/Lorazepam.. what seizures?

Answer 2

Increase FREQUENCY of GABA mediated Cl- channel opening

Status epilepticus (lots of seizures in a row or one that lasts more than 5 minutes)

Question 3

Gabapentin. what seizures?

Answer 3

Inhibit Ca++ channels

Simple and complex partial

Question 4

Carbamazepine
Mech
Adverse effects
Seizures

Answer 4

MOA - inhibit Na+ channels

AE - drug drug interactions, Stevens Johnson Syndrome in Asians

Seizures - simple, complex, tonic clonic

Question 5

Ethosuximide
MOA
AE
SEIZURES

Answer 5

MOA - Block T type Ca++ channels

AE - drug drug interactions, SLE, behavior ∆

Seizures - ABSENCE

It sux to have silent seizures

Question 6

Levetiracetam
MOA
Seizures

Answer 6

MOA - ∆ SV2A protein (synaptic vesicle protein) –> decreased glutamate release and increased GABA release

Seizures - simple, complex, tonic clonic

Question 7

Phenytoin
MOA
AE
Seizures

Answer 7

MOA - Na+ inactivation –> decreased glutamate release

AE - drug drug interactions, cerebellar atrophy (chronic), nystagmus

Seizures - simple, complex, tonic clonic, status epilepticus

Question 8

Valproic Acid
MOA
AE
Seizures

Answer 8

MOA - block Na+ channels, decrease GAT1 (GABA reuptake), decrease Ca++ T type channel flow

AE - drug drug interactions, appetite stimulation, alopecia, increased ALT/AST

Seizures - simple, complex, tonic clonic, absence

Question 9

Topiramate
MOA
AE
Seizures

Answer 9

MOA - Na+ channel inactivation –> blocked Ca++ channels, increase GABA, decrease glutamate

AE - psychomotor slowing, memory issues

Seizures - simple, complex, tonic clonic

Question 10

What treats absence seizures?

Answer 10

Ethosuximide

Valproic acid

Question 11

What treats status epileptics?

Answer 11

Diazepam/Lorazepam

Phenytoin