SLE Flashcards
(26 cards)
95% of pxs. earliest abnormality
Arthralgia
most common cause of death after 1st Five yrs
thromboses
Predictor for Poor prognoses
Renal involvement
Anti-body of relatively high specificity for active nephritis
Anti ds dna antibody and anti c1q antibody
most frequent cardiac manifestation
Pericarditis
A marker for patients at risk for CNS lesions
Livedo reticularis
Drugs that cause drug iduced LE
Hydralazine procainamide sulfonamide penicillin anticonvulsant minocycline isoniazid
DRUGS LE- PSH PAIM
HLA DR 4 individuals who are slow acetylators are predisposed to develop what
Hydralazine induced LE
age of onset of childhood SLE
bet 3-15 yo
girls more
oral mucosa freq involved.
CYBB mutations have an What type of inheritance and carriers have a higher risK of DLE and SLE
X libked inheritance
T suppressor cell function is inc or dec in px w LE ?
Decreased
most frequent findings in urine
Albumin, rbc and casts
AN a is positive and how many percent of SLE
95%
Correlates with high-risk of renal disease
Ds DNA
antibody common in SCLE And sjogren syndrome
ANti La antibodies
found in 25% of SLE and 40% of sjogren syndrome
Anti Ro antibodies
The safest agent for LE is what
anti malarials
The single most effective local treatment for LE
Injection of steroid into lesion . triamcinolone acetonide 2.5-10mg/ml is injected at 4-6 wk interval. No more than 40 mg of triamcinolone.
Drug particularly helpful in treating hypertrophic LE
Retinoids
Thalidomide can be effective but is limited by the risk of
teratogenicitt and neuropathy.
TNT
Drug of choice for bullous systemic LE
dapsone
Systemic treatment reserved for acute flares of disease
oral Prednisone
First line systemic therapy in most forms of cutaneous LE
Antimalarial- Hyrdoxychloroquine (plaquenil) 5mg/kg/day.
Side effect for chloroquine this. it is used if there is no response after three months of treatment
ocular toxicity
