SLE, SS, SSc Flashcards
What are the GI manifestations of systemic sclerosis?
esophageal dysmotility with markedly diminished peristalsis
No wrinkles is associated with what condition?
systemic sclerosis
What is unique in the arthritis seen in SLE?
they are nonerosive to bone
What 2 medications will help with dry mouth (xerostomia) seen in Sjogren syndrome
- Cevimeline
- Pilocarpine
90% of SLE cases are in what gender?
women
What are the pulmonary manifestations of systemic sclerosis? (3)
- interstitial lung disease (pulmonary fibrosis)
- pulmonary hypertension
- lung cancer
If a patient is having a severe or life threatening SLE flair what is the acute treatment?
- hospital admission for high dose IV steroids
Baby born to a mother with SLE may develop what 2 manifestations?
- self limited cutaneous rash that will get better in time
- heart blocks (any degree)
- if 3rd degree HB need a pacemaker for life*
- are at higher rate for autoimmune diseases later in life*
What 3 non-pharmacological treatment options are recommended for SLE?
- exercise
- smoking cessation
- sunscreen
Which organ systems does lupus NOT involve?
trick question - it can involve any organ
Patients with Sjogren Syndrome are at high risk for what 5 complications?
- dental caries
- oral candidiasis
- bacterial sialadenitis
- corneal damage
- vaginal dryness and dyspareunia
What is the number 1 symptom in SLE?
profound fatigue
How is drug-induced SLE diagnosis made?
- positive anti-histone antibody
What is necessary to make the diagnosis of Sjogren Syndrome?
- Positive Schirmer test OR imaging with glandular abnormalities
- salivary gland biopsy OR Anti-Ro (SSA) AND/OR Anti-La (SSB) antibodies
What other antibodies, besides ANA, are associated with SLE? (3)
- Anti-DS DNA
- Anti-Sm (Smith)
- Antiphospholipid antibodies
What are the 5 signs of CREST syndrome associated with limited cutaneous SSc?
- calcinosis
- Raynaud phenomenon
- esophageal dysmotility
- sclerodactyly
- telangiectasias
The production of a high number of _________ antibodies are associated with SLE
antinuclear antibodies (ANA)
ANA is a very _______ antibody. It is good to rule OUT SLE.
sensitive
This is a chronic inflammatory autoimmune disease that can affect essentially any organ of the body.
Systemic Lupus Erythematosus (SLE)
What test do we do to measure tear production when working-up Sjogren Syndrome?
Schirmer Test
- normal = 15-25mm
- SS = <10mm
What life saving medication should be administered in a patient with scleroderma renal crisis in systemic sclerosis?
ACE inhibitors
This is a chronic systemic autoimmune disorder associated with collagen deposition in the dermis, blood, and internal organs.
systemic sclerosis
What are the renal manifestations of systemic sclerosis?
scleroderma renal crisis = a deadly hypertensive crisis with BP >200/100
What are the 11 criteria for SLE?
- malar rash
- discoid rash
- oral ulcers
- photosensitivity
- arthritis
- serositis (e.g. pleuritis/pericarditis)
- renal disorder (lupus nephritis)
- neurologic disorder (e.g. seizures, psychosis)
- hematologic disorder (e.g. anemia or any -penias)
- ANA positive
- immunologic disorder
