Sleep

Question 1

Evidence for sleep as a behavioral state (6)

Answer 1

Behavioural quiescence
Specific site for sleep
Sleep posture
Increased arousal threshold
Rapid reversibility
Homeostatis, such as rebound after deprivation
Usually occurs within a 24hr rhythm

Question 2

Two process model of sleep regulation

Answer 2

Process C - clock

Process S - homeostat

Question 3

What is a measure of sleep depth

Answer 3

Delta power SWS

Question 4

What is a homeostatic chemical regulator of sleep

Answer 4

Adenosine

Question 5

Adenosine sleep hypothesis

Answer 5

Its a by product of energy metabolism
Accumulates in the extracelluar space of basal forbrian during wakefullness and decreases during sleep
When adenosine is increased, sleep increases so is a measure of when we need to sleep
Adenosine antagonist is caffeine that increases wakefullness

Question 6

Effects of sleep depravation on rats

Answer 6

Increase in food intake and energy expenditure
Weight loss
Temperature increases then crashes
Skin lesions due to susceptivitiy to infections
Death after 10-20 days

Question 7

Effect of sleep depravation on droshilla

Answer 7

Deeath in 3 days

Question 8

Fatal famililal insomnia

Answer 8

Stop sleepin gin 40s then die

Point muttation in PrP which damages the hypothalamus and thalamus

Question 9

Sleep paralysis

Answer 9

Wake from REM sleep but still have muscle paralysis

Question 10

Other chemicals that can induce sleep

Answer 10

TNF
IL1
Growth hormone releasing hormone
PGD2

Question 11

Functions of sleep

Answer 11

Sleep repair hypothesis
Sleep homostasis hypothesis
Washing machine hypothesis