Small Group 1: Gram Positive Cocci Flashcards Preview

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Flashcards in Small Group 1: Gram Positive Cocci Deck (14):
1

Coagglutination specific for what?

Ab to Staph aureus

2

Bacitracin inhibits what?

GAS

3

PYR test is positive for which 2 organisms?
What is substrate?
What is positive sign?

Group A and D strep (Enterococci)
Substrate is L-pyrroglutamyl-aminopeptidase
Cherry red color develops due to hydrolysis of substrate

4

Findings suggestive of strep pharyngitis:

Sudden onset sore throat; age 5-15; fever; headache; nausea, vomiting / abdominal pain; red swollen tonsils covered with exudate; petechiae on the palate; tender anterior cervical nodes (if not tender, prob not GAS), scarlet fever-like rash, and a history of exposure to someone with GAS pharyngitis.

5

Findings suggestive of viral pharyngitis

Conjunctivitis, coryza (irritation of mucus membranes in nose), cough, diarrhea, hoarseness, mouth ulcers, and a viral rash.

6

Why should abdominal exam be done for pharyngitis?

Splenomegaly suggests mononucleosis (EBV)

7

Tx for GAS pharyngitis
1st line?
Allergy?

1st line is penicillin or amoxicillin.
If allergic use cephalosporin, clindamycin, or macrolide.

8

What usually causes a peritonsillar abscess?

Anaerobic bacteria

9

Difference b/w toxic shock and septic shock

Toxic shock is a subset of septic shock.
Septic shock caused by immune system over-responding to an antigen.
Toxic shock is caused directly by the super-antigens.

10

How does super antigen cause shock?

Locks T cell to APC --> high TNF and IL-1 release

11

Is bacteremia more common in TSS from Strep or Staph?

Strep

12

Tx for TSS

•IV fluids to increase BP (most important)
•AB’s – naficillin for S aureus, penicillin G for GAS. Clindamycin for both b/c it decreases production of the toxin (protein synthesis inhibitor).
•Supportive control such as ventilator, dialysis, or blood
•Source control – debridement for Strep, tampon / surgical packing removal for Staph.

13

What general type of bacteria are most nosocomial infections caused by?

Resistant GNR's

14

What does coagulase do?

Converts fibrinogen → fibrin → clot