Small Intestine/Colon 1 Path - Nelson Flashcards Preview

Gastrointestinal - Week 4 > Small Intestine/Colon 1 Path - Nelson > Flashcards

Flashcards in Small Intestine/Colon 1 Path - Nelson Deck (7)
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1
Q

3 overall causes of ischemic bowel disease?

A

Acute obstruction

Mesenteric Venous Thrombosis

Hypoperfusion

2
Q

Complications of transmural bowel necrosis?

A

Sepsis once the mucosal layer us broken down

Could cause septic shock and death

3
Q

What segments of bowel are most likely to be affected by ischemia?

A

Segments at the end of an arterial supply

Splenic flexure, sigmoid colon, rectum

4
Q

What is the name for a lesion consisting of malformed submucosa and mucosa blood vessels?

A

Angiodysplasia

  • 20% of lower GI bleeds
5
Q

Quick Pathophysiology of celiac sprue:

Go!

A
  • Gliatin in gluten triggers cytotoxic t-cell immune response
  • Epithelial cell damage causes villous atrophy
  • Malabsorption issues occur
6
Q

What is Whipple Disease?

A

Systemic infection with Tropheryma Whippelii

Organism-laden foamy macrophages accumulate in the lamina propria of small bowel (and other organs)

See diarrhea,weight loss, malabsorption, and abdominal pain

7
Q

What is abetalipoproteinemia?

A

It is an autosomal recessive mutation in the MTP protein

Presents in infancy with build-up of TGs in the cytoplasm because transepithelial transport of TGs can’t occur

See spiny burr cells