Smoking and the Lung

Question 1

What is the definition of chronic bronchitis?

Answer 1

cough and sputum brought up most days for at least 3 months

Question 2

What is the anatomical definition of emphysema?

Answer 2

abnormal and permanent dilation of the airspace distal to the terminal bronchioles with destruction of their walls

Question 3

What is the pathology of chronic bronchitis?

Answer 3

hypertrophy of submucosal glands

increased number of goblet cells

mucocillary dysfunction

Question 4

What is the pathophysiology of emphysema?

Answer 4

degraded elastin leading to hyperinflation of alveoli, loss of lung elasticity, destruction of alveolar walls

Question 5

COPD can be described as multi-component. What are these three components?

Answer 5

inflammation

tissue damage

mucocillary dysfunction

Question 6

What is a possible genetic cause of emphysema?

Answer 6

alpha-1 antitrypsin deficiency

the main function of this protein is to keep white blood cells from damaging normal tissue, without this protein white blood cells continously damage lung tissue

Question 7

What will the spirometry trace